CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

This study tests a drug called tezepelumab in 230 Chinese adults with chronic sinusitis and nasal polyps. Participants receive injections every four weeks for six doses. Researchers will measure changes in polyp size and nasal congestion over 24 weeks to see if the treatment help…

This study is testing whether adding dupilumab to standard steroid nasal sprays improves symptoms and sense of smell in people with chronic sinusitis and nasal polyps. It focuses on a diverse, mostly minority group of 60 adults. Participants will receive dupilumab injections and …

This study tests an experimental injection called SHR-1905 in 280 adults with chronic sinusitis and nasal polyps. Participants must have moderate-to-severe symptoms despite standard nasal sprays. The goal is to see if the drug shrinks polyps and improves congestion over 24 weeks …

This study looks at whether people with chronic nasal polyps who are stable on biologic drugs like dupilumab or mepolizumab can safely extend the time between doses from every 4 weeks to every 6 or 8 weeks. The goal is to see if symptom control can be maintained with fewer inject…

This study tests whether transplanting nasal bacteria from a healthy donor can relieve chronic sinusitis. Fifty adults with sinusitis will receive either the bacteria rinse or a placebo for five days. The goal is to see if symptoms improve and if the nasal microbiome becomes heal…

This study tests whether a 3D-printed replica of a person's own nose can help them position their head better when using steroid nasal rinses. 200 adults with chronic sinusitis will use a daily steroid rinse for 8 weeks, with some getting the 3D model to guide their head position…

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study follows 200 Chinese patients with chronic sinusitis and nasal polyps who have had sinus surgery. Researchers will track symptoms, quality of life, and disease control for a year using standard questionnaires and exams. The goal is to understand real-world recovery patt…

This early lab study from Johns Hopkins University examines how mepolizumab (Nucala) affects the health and function of nasal cells from people with chronic sinusitis and nasal polyps. Researchers will measure changes in inflammation markers and cell barrier integrity. Only 8 par…