CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

This study is testing whether a new injectable medication called SHR-1905 can safely reduce the size of nasal polyps and improve symptoms like congestion and loss of smell in adults with chronic sinusitis. It will compare the drug against a placebo (inactive) injection in about 2…

This study is testing whether adding the medication dupilumab to standard nasal sprays improves symptoms and sense of smell in patients with chronic sinusitis and nasal polyps. It focuses on including more racial and ethnic minority patients, who are often underrepresented in res…

This study follows adults with chronic sinusitis and nasal polyps who previously tried lunsekimig in an earlier trial. Participants will receive lunsekimig for 52 weeks to check long-term safety and see if it continues to help control symptoms like congestion and smell loss. The …

This study is testing whether transferring healthy bacteria from a donor's nose into a patient's sinuses can help control chronic sinusitis. It builds on a small pilot study that showed promising symptom relief. The trial will enroll 50 people with long-term sinusitis to compare …

This study is testing an investigational injectable medication called itepekimab for adults whose chronic sinusitis with nasal polyps is not well-controlled by standard nasal steroid sprays. Over 52 weeks, researchers will compare two dosing schedules of itepekimab against a plac…

This study is testing if patients with chronic sinusitis and nasal polyps can safely take their biologic medicines (dupilumab or mepolizumab) less frequently. About 135 adults in Denmark who are already stable on these drugs will try extending the time between doses from 4 weeks …

This study is testing a new injectable medicine called itepekimab for adults whose chronic sinusitis and nasal polyps are not well-controlled by standard nasal sprays. Over 200 participants will receive either the new medicine or a placebo for one year, in addition to their usual…

This study is testing if a medication called tezepelumab can improve symptoms for adults with severe chronic sinusitis and nasal polyps who are eligible for surgery. About 180 participants will receive the drug for 24 weeks to see if it reduces nasal congestion, improves smell, a…

This is a laboratory study, not a treatment trial. Researchers are collecting nasal cells from 8 adults with chronic sinusitis and nasal polyps. They will test how the drug mepolizumab affects these cells in a dish to understand how it might reduce inflammation and help the nasal…