CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

This study looked at how safe and effective Xolair is for adults with chronic rhinosinusitis and nasal polyps when used in routine care. 135 patients who were already prescribed Xolair were followed to track side effects and changes in symptoms. The goal was to see how the drug p…

This study tests a drug called lunsekimig in adults with chronic sinusitis and nasal polyps that persist despite using steroid sprays. The drug is given as a shot under the skin every few weeks. Researchers will measure changes in polyp size and nasal congestion over 24 weeks. Th…

This study looked at whether the drug mepolizumab can improve symptoms in people with a specific combination of asthma, nasal polyps, and sensitivity to aspirin or similar painkillers. 95 adults received either mepolizumab or a placebo injection every month for 16 weeks. Research…

This study looked at how dupilumab, a drug that blocks certain immune signals, improves smell in adults with chronic sinusitis and nasal polyps. Researchers measured changes in inflammation in the smell region using CT scans, endoscopy, and mucus samples over three months. The go…

This phase 3 trial tested tezepelumab, a biologic drug given as a shot, in 416 adults with severe chronic sinusitis and nasal polyps. Participants received either tezepelumab or a placebo, plus a standard nasal steroid spray. The study measured changes in polyp size and nasal con…

This study tested whether taking a low dose of the antibiotic clarithromycin for three months after sinus surgery could prevent nasal polyps from coming back early. 100 adults who had surgery for nasal polyps were split into two groups: one received the antibiotic plus standard c…

This study tested a new medicine called TQC2731, given as an injection, to see if it is safe and works well for people with long-term sinus inflammation and nasal polyps (growths in the nose). The trial involved 59 adults who had already completed a previous study of the same dru…

This completed phase 4 trial directly compared two injectable drugs, dupilumab (Dupixent) and omalizumab (Xolair), in 360 adults with severe chronic rhinosinusitis with nasal polyps and asthma. The main goals were to see which drug better reduced polyp size and improved sense of …

This study tested the drug dupilumab in 63 Chinese adults with chronic sinusitis and nasal polyps. Participants received either dupilumab injections or a placebo, plus a standard nasal steroid spray, for 24 weeks. The main goal was to see if dupilumab could shrink nasal polyps an…

This study tested the drug dupilumab in 25 adults with chronic sinusitis and nasal polyps that weren't helped by other treatments. Participants received injections for up to 52 weeks. The main goal was to see if polyp size decreased by at least 1 point on a standard scale after 2…