Head-to-Head: which biologic works best for nasal polyps and asthma?

NCT ID NCT04998604

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed phase 4 trial directly compared two injectable drugs, dupilumab (Dupixent) and omalizumab (Xolair), in 360 adults with severe chronic rhinosinusitis with nasal polyps and asthma. The main goals were to see which drug better reduced polyp size and improved sense of smell after 24 weeks. Researchers also tracked symptom relief and quality of life. The study provides head-to-head evidence to guide treatment choices for this challenging condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Dupilumab (Dupixent) and Omalizumab (Xolair)

What this could lead to

If dupilumab proves better than omalizumab, it could offer a more effective treatment option for people with severe nasal polyps and asthma, improving breathing and quality of life.

What could go wrong

This is a completed phase 4 trial, so results are already known. However, individual responses vary, and both drugs have side effects like injection reactions or infections. The findings may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Contacts and locations

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Locations

Advanced ENT and Allergy Site Number : 8400013

Louisville, Kentucky, 40220, United States
Allergy, Asthma and Clinical Research Center Site Number : 8400037

Oklahoma City, Oklahoma, 73120, United States
Asthma Allergy & Immunology Clinical Research Unit Site Number : 8400027

Tampa, Florida, 33613, United States
Cedars Sinai Medical Center Site Number : 8400026

Los Angeles, California, 90048, United States
Chryaslis Clinical Research Site Number : 8400017

St. George, Utah, 84790, United States
Cleveland Clinic Foundation Site Number : 8400029

Cleveland, Ohio, 44195, United States
Eastern Virginia Medical School Site Number : 8400010

Norfolk, Virginia, 23507, United States
Essential Medical Research, LLC Site Number : 8400024

Tulsa, Oklahoma, 74137, United States
Investigational Site Number : 0560001

Ghent, 9000, Belgium
Investigational Site Number : 0560002

Leuven, 3000, Belgium
Investigational Site Number : 0560003

Woluwe-Saint-Lambert, 1200, Belgium
Investigational Site Number : 1240002

Montreal, Quebec, H4A 3J1, Canada
Investigational Site Number : 1240003

Québec, G1V 4G5, Canada
Investigational Site Number : 1240004

London, Ontario, N6A 5A5, Canada
Investigational Site Number : 2030001

Hradec Králové, 50005, Czechia
Investigational Site Number : 2030002

Pardubice, 53203, Czechia
Investigational Site Number : 2030003

Ostrava - Poruba, 70852, Czechia
Investigational Site Number : 2030004

Praha 5 - Motole, 15006, Czechia
Investigational Site Number : 2030006

Prague, 12808, Czechia
Investigational Site Number : 2030007

Benešov, 256 01, Czechia
Investigational Site Number : 2030008

Prague, 14059, Czechia
Investigational Site Number : 2030010

Prague, 10034, Czechia
Investigational Site Number : 2030012

Pilsen, 30599, Czechia
Investigational Site Number : 2080001

Copenhagen, 2100, Denmark
Investigational Site Number : 2080003

Aarhus, 8200, Denmark
Investigational Site Number : 2460002

Tampere, 33520, Finland
Investigational Site Number : 2460003

Helsinki, 00029 HUS, Finland
Investigational Site Number : 2500002

Lille, 59037, France
Investigational Site Number : 2500004

Marseille, 13005, France
Investigational Site Number : 2500005

Montpellier, 34295, France
Investigational Site Number : 2500006

La Roche-sur-Yon, 85925, France
Investigational Site Number : 2500007

Toulouse, 31059, France
Investigational Site Number : 2500008

Le Kremlin-Bicêtre, 94275, France
Investigational Site Number : 2500009

Créteil, 94010, France
Investigational Site Number : 2760001

Münster, 48149, Germany
Investigational Site Number : 2760002

Berlin, 13353, Germany
Investigational Site Number : 2760003

München, 81377, Germany
Investigational Site Number : 2760004

Düsseldorf, 40225, Germany
Investigational Site Number : 3480001

Szeged, 6725, Hungary
Investigational Site Number : 3480002

Pécs, 7621, Hungary
Investigational Site Number : 3480004

Budapest, 1115, Hungary
Investigational Site Number : 3480005

Debrecen, 4026, Hungary
Investigational Site Number : 3480006

Edelény, 3780, Hungary
Investigational Site Number : 3480007

Budapest, 1083, Hungary
Investigational Site Number : 3800001

Rozzano, Lombardy, 20089, Italy
Investigational Site Number : 3800002

Rome, Lazio, 00168, Italy
Investigational Site Number : 3800003

Catania, 95123, Italy
Investigational Site Number : 3800004

Florence, 50134, Italy
Investigational Site Number : 3800005

Varese, 21100, Italy
Investigational Site Number : 3800006

Milan, 20132, Italy
Investigational Site Number : 4840002

Chihuahua City, 31000, Mexico
Investigational Site Number : 4840003

Guadalajara, Jalisco, 44100, Mexico
Investigational Site Number : 4840004

Durango, 34000, Mexico
Investigational Site Number : 6160001

Krakow, 30-033, Poland
Investigational Site Number : 6160004

Poznan, Greater Poland Voivodeship, 60-693, Poland
Investigational Site Number : 6160005

Katowice, Silesian Voivodeship, 40-611, Poland
Investigational Site Number : 6160006

Środa Wielkopolska, 63000, Poland
Investigational Site Number : 6160007

Lodz, 90141, Poland
Investigational Site Number : 6160008

Warsaw, Masovian Voivodeship, 04-141, Poland
Investigational Site Number : 6200001

Matosinhos Municipality, 4454-509, Portugal
Investigational Site Number : 6200003

Aveiro, 3814-501, Portugal
Investigational Site Number : 6200005

Almada, 2801-951, Portugal
Investigational Site Number : 6200006

Guimarães, 4810-061, Portugal
Investigational Site Number : 6200007

Santa Maria da Feira, 4520-211, Portugal
Investigational Site Number : 6420002

Brasov, 500283, Romania
Investigational Site Number : 6420004

Craiova, 200222, Romania
Investigational Site Number : 7240001

Seville, Andalusia, 41009, Spain
Investigational Site Number : 7240003

Jerez de la Frontera, Cádiz, 11407, Spain
Investigational Site Number : 7240004

Madrid / Madrid, Madrid, Comunidad de, 28040, Spain
Investigational Site Number : 7240005

Barcelona, Barcelona [Barcelona], 08036, Spain
Investigational Site Number : 7240006

Pamplona, Navarre, 31080, Spain
Investigational Site Number : 7240007

Majadahonda, Madrid, 28222, Spain
Investigational Site Number : 7240008

L'Hospitalet de Llobregat, Barcelona [Barcelona], 08907, Spain
Investigational Site Number : 7520001

Stockholm, 171 76, Sweden
Investigational Site Number : 7520002

Lund, 221 85, Sweden
Investigational Site Number : 7520003

Gothenburg, 413 45, Sweden
Investigational Site Number : 8260001

Newcastle upon Tyne, NE7 7DN, United Kingdom
Investigational Site Number : 8260002

Manchester, M23 9LT, United Kingdom
Investigational Site Number : 8260003

Wigan, Lancashire, WN6 9EP, United Kingdom
Northwell Health Site Number : 8400044

Great Neck, New York, 11021, United States
Northwestern University Site Number : 8400001

Chicago, Illinois, 60611, United States
Optimed Research, LTD Site Number : 8400014

Columbus, Ohio, 43235, United States
Oregon Health & Science University Site Number : 8400031

Portland, Oregon, 97239, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Missouri Health Care - University Hospital Site Number : 8400016

Columbia, Missouri, 65212, United States
University of Rochester Site Number : 8400015

Rochester, New York, 14642, United States
University of Texas Health Science Center- Site Number : 8400019

Houston, Texas, 77030, United States