New shot could shrink nasal polyps and ease breathing

NCT ID NCT06454240

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called lunsekimig in adults with chronic sinusitis and nasal polyps that persist despite using steroid sprays. The drug is given as a shot under the skin every few weeks. Researchers will measure changes in polyp size and nasal congestion over 24 weeks. The trial includes 79 participants and is already completed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lunsekimig (a drug given as a shot under the skin)
What this could lead to: If it works, this could lead to a new treatment option for people with nasal polyps that are not well controlled with standard sprays.
What could go wrong: This is an early Phase 2 study with only 79 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Contacts and locations

Locations

Advanced Research Institute - Odgen- Site Number : 8400022

Ogden, Utah, 84405, United States
Alamo ENT Associates Site Number : 8400001

San Antonio, Texas, 78258, United States
Allergy & Rheumatology- Site Number : 8400005

La Jolla, California, 92037, United States
Berkson Medical - McKinney- Site Number : 8400014

McKinney, Texas, 75070, United States
Eastern Virginia Medical School (EVMS) Medical Group- Site Number : 8400008

Norfolk, Virginia, 23510, United States
Emory University Hospital Midtown- Site Number : 8400012

Atlanta, Georgia, 30308, United States
Essential Medical Research- Site Number : 8400020

Tulsa, Oklahoma, 74137, United States
Gary Gross Pharmaceutical Research & Consulting, Inc. Site Number : 8400004

Dallas, Texas, 75231, United States
Harvard Medical School - Brigham and Women's Hospital Site Number : 8400016

Boston, Massachusetts, 02115, United States
Investigational Site Number : 0320001

Buenos Aires, 1121, Argentina
Investigational Site Number : 0320002

Rosario, Santa Fe Province, 2000, Argentina
Investigational Site Number : 0320003

Mendoza, 5500, Argentina
Investigational Site Number : 0560001

Leuven, 3000, Belgium
Investigational Site Number : 0560002

Ghent, 9000, Belgium
Investigational Site Number : 1000001

Sofia, 1612, Bulgaria
Investigational Site Number : 6160001

Warsaw, Masovian Voivodeship, 00-909, Poland
Investigational Site Number : 6160002

Krakow, Lesser Poland Voivodeship, 31-033, Poland
Investigational Site Number : 6160003

Katowice, Silesian Voivodeship, 40-611, Poland
Investigational Site Number : 6160004

Poznan, 60-693, Poland
Investigational Site Number : 6160005

Warsaw, Masovian Voivodeship, 02-507, Poland
Investigational Site Number : 6160007

Wroclaw, 53-034, Poland
Investigational Site Number : 8260001

Newcastle upon Tyne, NE7 7DN, United Kingdom
Investigational Site Number : 8260003

Manchester, M13 9WL, United Kingdom
Investigational Site Number : 8260004

Gloucester, Gloucestershire, GL1 3NN, United Kingdom
James A Haley Veterans' Hospital- Site Number : 8400015

Tampa, Florida, 33612, United States
McGovern Medical School - UT Physicians Dermatology - Bellaire Station- Site Number : 8400017

Bellaire, Texas, 77401, United States
Sacramento Ear Nose & Throat - Roseville- Site Number : 8400003

Roseville, California, 95661, United States
Senta Clinic- Site Number : 8400025

San Diego, California, 92018, United States
The Allergy Group - Asthma & Allergy Boise- Site Number : 8400002

Boise, Idaho, 83706, United States

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