Scientists uncover how a nasal polyp drug improves sense of smell

NCT ID NCT05964465

Completed Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This study looked at how dupilumab, a drug that blocks certain immune signals, improves smell in adults with chronic sinusitis and nasal polyps. Researchers measured changes in inflammation in the smell region using CT scans, endoscopy, and mucus samples over three months. The goal was to understand the mechanism behind smell improvement, not to test the drug's effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dupilumab (a monoclonal antibody that blocks certain immune signals)
What this could lead to: If successful, this could clarify how dupilumab restores smell, potentially leading to better treatments for nasal polyps and smell loss.
What could go wrong: This is a small, completed Phase 4 study (60 people) focused on understanding mechanisms, not proving long-term benefit. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Contacts and locations

Locations

Medical University of South Carolina

Charleston, South Carolina, 29425, United States
University of Virginia

Charlottesville, Virginia, 22904, United States

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