New biologic shot could ease severe nasal polyps

NCT ID NCT04851964

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested tezepelumab, a biologic drug given as a shot, in 416 adults with severe chronic sinusitis and nasal polyps. Participants received either tezepelumab or a placebo, plus a standard nasal steroid spray. The study measured changes in polyp size and nasal congestion over 52 weeks. The goal is to see if tezepelumab can improve symptoms and reduce the need for surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tezepelumab (a biologic drug given as a shot under the skin)

What this could lead to

If it works, this could offer a new treatment option for people with severe nasal polyps who have not responded well to standard therapies, potentially reducing the need for surgery.

What could go wrong

This is a phase 3 trial, but results are not yet published. The drug may not work better than placebo, and side effects are possible. It is not a cure—ongoing treatment would likely be needed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Contacts and locations

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Locations

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Birmingham, Alabama, 35209, United States
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Bakersfield, California, 93301, United States
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Newport Beach, California, 92663, United States
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Roseville, California, 95661, United States
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Walnut Creek, California, 94598, United States
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Colorado Springs, Colorado, 80923, United States
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Denver, Colorado, 80230, United States
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Boca Raton, Florida, 33487, United States
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Chicago, Illinois, 60657, United States
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Baltimore, Maryland, 21224, United States
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White Marsh, Maryland, 21162, United States
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Boston, Massachusetts, 02115, United States
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Columbia, Missouri, 65212, United States
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New York, New York, 10003, United States
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Winston-Salem, North Carolina, 27103, United States
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Oklahoma City, Oklahoma, 73120, United States
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North Charleston, South Carolina, 29406, United States
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Dallas, Texas, 75231, United States
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Norfolk, Virginia, 23507, United States
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Spokane, Washington, 99201, United States
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Milwaukee, Wisconsin, 53228, United States
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Vancouver, British Columbia, V6Z 1Y6, Canada
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Hamilton, Ontario, L8S 1G5, Canada
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London, Ontario, N6A 4V2, Canada
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Montreal, Quebec, H2V 2K1, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Québec, Quebec, G1V 4G5, Canada
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Québec, Quebec, G1V 4W2, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Bengbu, 233004, China
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Chengdu, 610072, China
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Guangzhou, 510120, China
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Hangzhou, 310003, China
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Hangzhou, 310014, China
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Hengyang, 421001, China
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Lanzhou, 730030, China
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Nanchang, 330006, China
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Nanjing, 210009, China
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Qingdao, 266011, China
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Shanghai, 200031, China
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Shanghai, 200433, China
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Suzhou, 215006, China
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Taizhou, 225300, China
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Tianjin, 300121, China
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Tianjin, 300211, China
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Wenzhou, 325027, China
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Wuhan, 430060, China
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Xi'an, 710068, China
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Yinchuan, 750001, China
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Zunyi, 563100, China
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Aalborg, 9000, Denmark
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Aarhus N, 8200, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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København NV, 2400, Denmark
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Køge, 4600, Denmark
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Odense, 5000, Denmark
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Vejle, 7100, Denmark
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Berlin, 10629, Germany
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Berlin, 13353, Germany
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Dresden, 01307, Germany
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Heidelberg, 69120, Germany
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Lübeck, 23538, Germany
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Marburg, 35043, Germany
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Tübingen, 72076, Germany
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Wiesbaden, 65183, Germany
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Budapest, 1046, Hungary
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Budapest, 1083, Hungary
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Budapest, 1134, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7621, Hungary
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Siófok, 8600, Hungary
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Székesfehérvár, 8000, Hungary
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Bunkyō City, 113-8431, Japan
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Chuo-shi, 409-3898, Japan
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Habikino-shi, 583-0886, Japan
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Ichikawa-shi, 272-0111, Japan
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Itabashi-ku, 173-8610, Japan
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Kashiwa-shi, 277-0882, Japan
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Kisarazu-shi, 292-8535, Japan
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Miyazaki, 880-8510, Japan
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Nagaoka-shi, 940-8621, Japan
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Nerima-ku, 177-0035, Japan
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Niigata, 951-8520, Japan
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Osaka, 553-0003, Japan
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Saitama-shi, 336-8522, Japan
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Sapporo, 003-0022, Japan
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Sendai, 983-8512, Japan
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Suwa-shi, 392-8510, Japan
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Toyonaka Shi, 560-0082, Japan
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Yokohama, 227-8501, Japan
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Yokohama, 236-0037, Japan
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Bialystok, 15-879, Poland
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Bydgoszcz, 85-231, Poland
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Krakow, 31-513, Poland
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Nadarzyn, 05-830, Poland
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Wroclaw, 50-556, Poland
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Wroclaw, 53-301, Poland
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Zawadzkie, 47-120, Poland
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Łodź, 90-153, Poland
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Barakaldo, 48903, Spain
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Barcelona, 08036, Spain
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Jerez de la Frontera, 11407, Spain
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Madrid, 28040, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41009, Spain
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Dundee, DD1 9SY, United Kingdom
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London, SE1 9RT, United Kingdom
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Manchester, M13 9WL, United Kingdom
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Stockport, SK2 7JE, United Kingdom