CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

This study is testing whether adding the drug dupilumab to standard nasal steroid sprays can improve symptoms and sense of smell in people with chronic sinusitis and nasal polyps. The trial focuses on ethnic and racial minority groups, who are often underrepresented in research. …

This study looks at whether people with chronic sinusitis and nasal polyps can safely take their biologic injections (like dupilumab or mepolizumab) less often without losing symptom control. About 135 adults who have been stable on these drugs for at least a year will have their…

This study looks at the long-term safety and effectiveness of a drug called lunsekimig in adults with chronic sinusitis and nasal polyps that are not well controlled. Participants must have completed a previous lunsekimig study and will receive the drug for about 52 weeks, with a…

This study tests if transplanting healthy bacteria into the nose can reduce symptoms of chronic sinusitis, a condition where sinuses stay inflamed for months. About 50 adults with chronic sinusitis will receive either a bacteria transplant or a placebo, then switch groups later. …

This study tests a new drug called itepekimab for adults with chronic sinusitis and nasal polyps that are not well controlled with standard sprays. About 210 participants will receive either the drug or a placebo for 52 weeks, alongside their usual nasal spray. The goal is to see…

This study tests a drug called tezepelumab in 180 adults with chronic sinusitis and nasal polyps who are eligible for surgery. The goal is to see if the drug can reduce nasal congestion and other sinus symptoms over 24 weeks. Participants receive the drug every 4 weeks and report…

This study tests a drug called itepekimab in adults with chronic sinusitis and nasal polyps that are not well controlled by standard treatments. About 210 participants will receive either the drug or a placebo for up to 52 weeks, alongside their usual nasal spray. The goal is to …

This study is for people with chronic sinusitis and nasal polyps who have trouble sleeping. Researchers want to see if endoscopic sinus surgery can improve sleep quality, especially deep sleep. Thirty adults will have their sleep measured before and three months after surgery to …

This study tests an experimental drug called SHR-1905 for people with long-term sinus inflammation and nasal polyps (growths in the nose). About 280 adults will receive either the drug or a placebo to see if it reduces polyp size and nasal congestion over 24 weeks. Participants m…

This early-stage lab study uses cells from 8 people with chronic sinusitis and nasal polyps to see how the drug mepolizumab affects inflammation and the health of the cells lining the nasal passages. Researchers want to understand if mepolizumab can reduce inflammation and help m…

This study follows 200 Chinese patients with chronic sinusitis and nasal polyps after they have surgery. Researchers will track symptoms, quality of life, and disease control for one year using questionnaires and nasal exams. The goal is to understand real-world outcomes and trea…