Could a healthy Person's nose bacteria cure sinusitis?
NCT ID NCT07184684
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether transplanting nasal bacteria from a healthy donor can relieve chronic sinusitis. Fifty adults with sinusitis will receive either the bacteria rinse or a placebo for five days. The goal is to see if symptoms improve and if the nasal microbiome becomes healthier.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sinonasal microbiome transplant (nasal lavage from a healthy donor)
- What this could lead to
- If it works, this could offer a new, non-surgical treatment for chronic sinusitis by restoring a healthy nasal microbiome.
- What could go wrong
- This is an early phase 2/3 trial with only 50 people. The previous pilot was small, and the placebo effect is strong in sinusitis studies. The treatment requires daily nasal rinses for five days, which may be inconvenient.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Departement of ORL
RECRUITINGHelsingborg, 25187, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a drug that calms inflammation ease chronic sinusitis?
- Can a new drug shrink nasal polyps and restore smell?
- Greek sinusitis study aims to personalize treatment by analyzing inflammation
- Triple-Action nasal spray could ease chronic sinusitis
- 3D-Printed nose models could boost sinus rinse results
- Sinus surgery may ease sleep problems in nasal polyp patients