Baby teeth stem cells may spare kids a second surgery for cleft palate repair

NCT ID NCT07734974

Completed Symptom relief Sponsor: Hospital Sirio-Libanes Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether stem cells from children's shed baby teeth can replace the standard hip bone graft for repairing a cleft in the upper jaw. Twenty children aged 7 to 12 with cleft lip and palate will receive either the stem cell graft or a traditional bone graft from their hip. Researchers will compare pain levels, painkiller use, and hospital costs between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stem cells from baby teeth (SHED) combined with a collagen-hydroxyapatite scaffold
What this could lead to: If successful, this approach could eliminate the need for a second surgical site, reducing pain and recovery time for children with cleft lip and palate.
What could go wrong: This is an early-phase trial with only 20 participants, so results may not apply broadly. The stem cell graft may not form bone as reliably as the standard hip bone graft.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ALVEOLAR BONE LOSS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss cleft lip cleft lip and alveolus cleft lip/palate cleft palate Pain, Postoperative periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR BONE LOSS CLEFT PALATE CLIFT LIP POSTOPERATIVE PAIN

Contacts and locations

Locations

Hospital Sírio-Libanês

São Paulo, São Paulo, 01308050, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.