New biologic drug aims to ease joint pain and swelling in Tough-to-Treat psoriatic arthritis

NCT ID NCT03671148

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizumab or a placebo injection for 24 weeks. The main goal is to see if more people on risankizumab achieve at least a 20% improvement in tender and swollen joint counts and other measures of disease activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: risankizumab, an injectable biologic drug that blocks inflammation
What this could lead to: If successful, risankizumab could offer a new treatment option for people with psoriatic arthritis who have not responded to other biologic therapies.
What could go wrong: This is a single phase 3 trial; results may not confirm benefit in broader populations, and risks include infection and allergic reactions common to biologic drugs.

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIATIC ARTHRITIS (PSA)

Contacts and locations

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Locations

Aarhus University Hospital /ID# 168762

Aarhus C, Central Jutland, 8000, Denmark
Altoona Ctr Clinical Res /ID# 166691

Duncansville, Pennsylvania, 16635, United States
Amarillo Ctr for Clin Research /ID# 208340

Amarillo, Texas, 79124, United States
Antonius Ziekenhuis /ID# 208581

Sneek, Provincie Friesland, 8601 ZK, Netherlands
Arthritis & Osteo Medical Ctr /ID# 166541

La Palma, California, 90623-1728, United States
Arthritis & Rheumatic Disease Specialties /ID# 212582

Aventura, Florida, 33180, United States
Arthritis Center, Inc. /ID# 208116

Palm Harbor, Florida, 34684, United States
Arthritis Clinical Research Trials /ID# 167611

Cape Town, Western Cape, 7405, South Africa
Arthritis Northwest, PLLC /ID# 169535

Spokane, Washington, 99204-2302, United States
Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 166658

Voorhees Township, New Jersey, 08043, United States
Arthritis and Rheumatology /ID# 169438

Atlanta, Georgia, 30342, United States
Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Roma /ID# 207264

Verona, 37134, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 207268

Ancona, 60126, Italy
Barzilai Medical Center /ID# 207471

Ashkelon, 7830604, Israel
BayCare Medical Group /ID# 201630

St. Petersburg, Florida, 33705, United States
Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 209054

Budapest, 1023, Hungary
Bispebjerg and Frederiksberg Hospital /ID# 168763

Frederiksberg, Capital Region, 2000, Denmark
CGM Research Trust /ID# 210596

Burwood Christchurch, 8083, New Zealand
CHRU Tours - Hopital Trousseau /ID# 209343

Chambray-lès-Tours, 37170, France
CIADS Research Co Ltd /ID# 169526

Winnipeg, Manitoba, R3N 0K6, Canada
CIP - Centro Internacional de Pesquisa /ID# 169524

Goiânia, Goiás, 74110-120, Brazil
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 169248

Miskolc, Borsod-Abauj Zemplen county, 3529, Hungary
Center of Innovative Diagnostics and Therapeutics (CIRI GmbH) /ID# 209494

Frankfurt, 60590, Germany
Centre Rhumatologie de l'Est /ID# 208302

Rimouski, Quebec, G5L 8W1, Canada
Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 208139

Lisbon, 1649-035, Portugal
Centro Medico Privado de Reumatologia /ID# 208342

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 169151

Rosario, Santa Fe Province, 2000, Argentina
Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 208012

Gdansk, Pomeranian Voivodeship, 80-546, Poland
Centrum Kliniczno-Badawcze /ID# 208014

Elblag, Warmian-Masurian Voivodeship, 82-300, Poland
Centrum Medyczne Reuma Park w Warszawie /ID# 210956

Warsaw, Masovian Voivodeship, 02-691, Poland
Changi General Hospital /ID# 208966

Singapore, 529889, Singapore
Cimer /Id# 169155

San Miguel de Tucumán, 4000, Argentina
Clayton Medical Associates, P.C. dba Saint Louis Rheumatology /ID# 166389

St Louis, Missouri, 63119-3845, United States
Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 166681

Skokie, Illinois, 60076, United States
Clinical Pharmacology Study Gr /ID# 166455

Worcester, Massachusetts, 01605, United States
Clinical Research Ctr Reading /ID# 166354

Wyomissing, Pennsylvania, 19610, United States
Clinvest Research LLC /ID# 166745

Springfield, Missouri, 65810-2607, United States
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 207822

Sabadell, Barcelona, 08208, Spain
DM Clinical Research /ID# 208350

Tomball, Texas, 77375, United States
DOM Centro de Reumatologia /ID# 208478

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, 1111, Argentina
Dartmouth-Hitchcock Medical Center /ID# 169443

Lebanon, New Hampshire, 03756, United States
Denver Arthritis Clinic /ID# 166442

Denver, Colorado, 80230, United States
Dermatrials Research /ID# 208303

Hamilton, Ontario, L8N 1Y2, Canada
Dr Jenny Potts /ID# 167628

Port Elizabeth, Eastern Cape, 6405, South Africa
Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 207800

Modena, Emilia-Romagna, 41124, Italy
Duplicate_Barts Health NHS Trust /ID# 210794

London, London, City of, E11 1NR, United Kingdom
Duplicate_CHU Bordeaux-Hopital Pellegrin /ID# 211159

Bordeaux, 33076, France
Duplicate_Karolinska Univ Sjukhuset /ID# 208174

Solna, 171 64, Sweden
Duplicate_The Center for Rheumatology & Bone Research /ID# 166448

Wheaton, Maryland, 20902, United States
Duplicate_Vastmanlands Sjukhus /ID# 168620

Västerås, 723 35, Sweden
Duplicate_Wirral University Teaching Hospital NHS Foundation Trust /ID# 210536

Metropolitan Borough of Wirral, CH49 5PE, United Kingdom
East Bay Rheumatology Medical /ID# 166845

San Leandro, California, 94578, United States
East Tallinn Central Hospital /ID# 208317

Tallinn, Harju, 10138, Estonia
Emeritus Research /ID# 207195

Camberwell, Victoria, 3124, Australia
ForCare Clinical Research /ID# 166375

Tampa, Florida, 33613-1244, United States
GCM Medical Group PSC - Hato Rey /ID# 208461

San Juan, 00917-3104, Puerto Rico
Glacier View Research Institute /ID# 169344

Kalispell, Montana, 59901, United States
Griffith University /ID# 207504

Southport, Queensland, 4222, Australia
HMD Research LLC /ID# 208428

Orlando, Florida, 32819, United States
Health Research of Oklahoma /ID# 166408

Oklahoma City, Oklahoma, 73103-2400, United States
Hospital General de Agudos J. M. Ramos Mejia /ID# 169152

Buenos Aires, Ciuadad Autonoma de Buenos Aires, 1221, Argentina
Hospital Italiano de Buenos Aires /ID# 208473

Ciudad Autonoma Buenos Aires, Ciuadad Autonoma de Buenos Aires, 1199, Argentina
Hospital Universitario 12 de Octubre /ID# 207820

Madrid, 28041, Spain
Hospital Universitario A Coruna - CHUAC /ID# 207819

A Coruña, 15006, Spain
Hospital Universitario y Politecnico La Fe /ID# 207823

Valencia, 46026, Spain
Hospital Unversitario Marques de Valdecilla /ID# 208541

Santander, Cantabria, 39008, Spain
IRIS Research and Development, LLC /ID# 166351

Plantation, Florida, 33324, United States
Immanuel Krankenhaus Berlin /ID# 207214

Buch, 13125, Germany
Inland Rheum Clin Trials Inc. /ID# 166621

Upland, California, 91786, United States
Instituto CAICI /ID# 169156

Rosario, Santa Fe Province, 2000, Argentina
Instituto Português De Reumatologia /ID# 208140

Lisbon, 1050-034, Portugal
Ite Pihlajanlinna Kuopio /ID# 208316

Kuopio, 70100, Finland
K. Papp Clinical Research /ID# 169527

Waterloo, Ontario, N2J 1C4, Canada
Kadlec Clinic Rheumatology /ID# 167667

Kennewick, Washington, 99336, United States
Klein and Associates MD /ID# 166549

Hagerstown, Maryland, 21740, United States
LMK Sevicos Medicos S/S /ID# 169541

Porto Alegre, Rio Grande do Sul, 90480-000, Brazil
MMP Women's Health /ID# 169334

Portland, Maine, 04102, United States
MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 209493

Hamburg, 20095, Germany
Malopolskie Centrum Kliniczne /ID# 208011

Krakow, Lesser Poland Voivodeship, 30-149, Poland
Manchester University NHS Foundation Trust /ID# 207923

Manchester, M13 9WL, United Kingdom
MediTrials /ID# 207815

Tartu, Tartu, 50708, Estonia
Medisch Centrum Leeuwarden /ID# 168449

Leeuwarden, 8934 AD, Netherlands
Meir Medical Center /ID# 207469

Kfar Saba, 4428164, Israel
Middlemore Clinical Trials /ID# 214293

Auckland, 2025, New Zealand
Millennium Research /ID# 201627

Ormond Beach, Florida, 32174, United States
Monash Medical Centre /ID# 208033

Clayton, Victoria, 3168, Australia
Nashville Arthritis and Rheumatology /ID# 208395

Nashville, Tennessee, 37203, United States
Naval Hospital of Athens /ID# 206928

Athens, 11521, Greece
New England Research Associates, LLC /ID# 166525

Bridgeport, Connecticut, 06606-1827, United States
Newport Huntington Medica /ID# 207423

Huntington Beach, California, 92648-5994, United States
North Estonia Medical Centre /ID# 208319

Tallinn, 13419, Estonia
Ocean Rheumatology, PA /ID# 166561

Toms River, New Jersey, 08755, United States
Ochsner Clinic Foundation /ID# 166622

Baton Rouge, Louisiana, 70836-6455, United States
Olympion General Clinic SA /ID# 207047

Pátrai, 26443, Greece
Orebro Universitetssjukhuset /ID# 169400

Örebro, Örebro County, 701 85, Sweden
Osteo-Medic S.C. /ID# 208013

Bialystok, Podlaskie Voivodeship, 15-351, Poland
Paramount Medical Research Con /ID# 166334

Middleburg Heights, Ohio, 44130, United States
Percuro Clinical Research, Ltd /ID# 169530

Victoria, British Columbia, V8V 3M9, Canada
Pinnacle Research Group /ID# 167953

Anniston, Alabama, 36207, United States
Precision Comprehensive Clinical Research Solutions /ID# 208156

Colleyville, Texas, 76034, United States
Rabin Medical Center /ID# 207470

Petah Tikva, 4941492, Israel
Rambam Health Care Campus /ID# 208169

Haifa, 3109601, Israel
ReumaClinic /ID# 208211

Genk, 3600, Belgium
Rheum Assoc of Central FL /ID# 201629

Orlando, Florida, 32806, United States
Rheumatic Disease Center, LLP /ID# 166682

Glendale, Wisconsin, 53217, United States
Rheumatology Clinic of Houston /ID# 166636

Houston, Texas, 77065, United States
Rheumatology Research Unit Sunshine Coast /ID# 207191

Maroochydore, Queensland, 4558, Australia
Rheumatology and Pulmonary Clinic /ID# 169341

Beckley, West Virginia, 25801, United States
Rheumazentrum Ruhrgebiet /ID# 207212

Herne, North Rhine-Westphalia, 44649, Germany
SIMED Health, LLC /ID# 207457

Gainesville, Florida, 32607-2817, United States
SW Rheumatology Res. LLC /ID# 166587

Mesquite, Texas, 75150, United States
Sheba Medical Center /ID# 207468

Ramat Gan, Tel Aviv, 5239424, Israel
Springfield Clinic /ID# 166345

Springfield, Illinois, 62702-3749, United States
St. Jude Heritage /ID# 166842

Fullerton, California, 92835, United States
St. Paul Rheumatology /ID# 166599

Eagan, Minnesota, 55121, United States
Sweet Hope Research Specialty Inc /ID# 168163

Hialeah, Florida, 33016-1897, United States
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 169237

Szeged, Csongrád megye, 6725, Hungary
Tekton Research, Inc. /ID# 166493

Austin, Texas, 78745, United States
The Arthritis & Diabetes Clinic, Inc. /ID# 166707

Monroe, Louisiana, 71203, United States
The Canberra Hospital /ID# 207591

Garran, Australian Capital Territory, 2605, Australia
Torbay and South Devon Nhs Foundation Trust /Id# 207926

Torquay, TQ2 7AA, United Kingdom
Trinity Universal Research Associates, Inc /ID# 208387

Plano, Texas, 75024-5283, United States
Turku University Hospital /ID# 208199

Turku, 20520, Finland
UZ Gent /ID# 210037

Ghent, Oost-Vlaanderen, 9000, Belgium
Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 208138

Ponte de Lima, Viana do Castelo District, 4990-041, Portugal
Universitair Medisch Centrum Groningen /ID# 168450

Groningen, 9713 GZ, Netherlands
Universitair Ziekenhuis Leuven /ID# 208209

Leuven, Vlaams-Brabant, 3000, Belgium
University General Hospital of Heraklion PA.G.N.I /ID# 206930

Heraklion, Crete, 71307, Greece
University of South Florida /ID# 208467

Tampa, Florida, 33612, United States
Uppsala University Hospital /ID# 169098

Uppsala, 75185, Sweden
Vital-Medicina Kft. /ID# 208123

Veszprém, Veszprém megye, 8200, Hungary
Waikato Hospital /ID# 214276

Hamilton, Waikato Region, 3204, New Zealand
West Broward Rheumatology Associates /ID# 201234

Tamarac, Florida, 33321, United States
West Tennessee Research Institute /ID# 166429

Jackson, Tennessee, 38305, United States
West Texas Clinical Research /ID# 208155

Lubbock, Texas, 79410-1198, United States
Winelands Medical Research Centre /ID# 167630

Stellenbosch, Western Cape, 7600, South Africa
Yale University /ID# 166330

New Haven, Connecticut, 06510, United States
ZNA - Jan Palfijn /ID# 208210

Merksem, 2170, Belgium

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