Bone disorder

This early-stage trial is testing an experimental cell therapy for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has returned or not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize …

This trial tests a new, lower-intensity combination of chemotherapy and radiation before a donor stem cell transplant for people with high-risk blood cancers or aplastic anemia. The goal is to see if this approach is safe enough to allow the donor cells to take hold and cure the …

This phase II trial tests a vaccine designed to protect stem cell transplant recipients from cytomegalovirus (CMV), a common virus that can cause serious illness in people with weakened immune systems. The vaccine uses a modified, harmless virus to deliver three CMV proteins, tra…

This study tests a new two-drug combination (pacritinib plus azacitidine) for people with moderate to very high risk myelodysplastic syndrome (MDS), a bone marrow disorder. The first part finds the safest dose of pacritinib, and the second part checks how well the combination wor…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease (a common complication where donor cells att…

This study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…

This phase 3 trial is testing whether adding radiation therapy to standard care can prevent bone complications like fractures or spinal cord compression in cancer patients with high-risk bone metastases that aren't causing symptoms yet. About 280 patients with multiple metastatic…

This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over …

This trial aims to see if there is a difference in how well two cementless total knee replacement implants hold up over time. About 50 people with knee osteoarthritis will be randomly assigned to receive either the Triathlon Tritanium or the GMK Sphere implant. Using CT scans, re…

This early-stage study tests a single intravenous dose of a gene therapy called LY3884961 in 15 adults with Gaucher disease type 1. The goal is to see if it is safe and can reduce or replace the need for ongoing enzyme replacement or substrate reduction therapy. Participants must…

This study tests a weekly injection called TransCon CNP in children and teens with achondroplasia, the most common form of dwarfism. The goal is to see if it is safe and helps improve growth over several years. Participants who completed a previous TransCon CNP trial can join thi…

This study tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. It uses a special mix of stem cells and immune cells from a donor to help the body accept the transplant while reducing serious side effects like graft-versus-host disease. The go…

This trial tests whether adding screws to secure the cup part of a hip replacement makes a difference in how well the implant stays in place. Participants aged 65-80 with hip osteoarthritis will receive a hybrid hip replacement, and half will get screws while the other half won't…

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

This trial is testing whether adding the targeted drug cabozantinib to standard chemotherapy (methotrexate, doxorubicin, and cisplatin) helps people with newly diagnosed osteosarcoma, a type of bone cancer. The study includes over 1,100 participants and aims to see if the combina…

This study tests a new drug called bomedemstat against the best available treatments for people with essential thrombocythemia (a blood disorder causing too many platelets) who did not respond well to or couldn't tolerate the standard drug hydroxyurea. About 340 adults will be ra…

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This trial compares the drug ruxolitinib against the best available standard treatments for people with high-risk polycythemia vera (PV) or essential thrombocythemia (ET), two rare blood cancers that cause overproduction of blood cells and can lead to clots, bleeding, and severe …

This phase 2 trial tested vismodegib, a pill that targets a specific growth pathway, in 45 people with advanced chondrosarcoma (a rare bone cancer). The goal was to see if the drug could shrink tumors or stop them from growing. Participants had to have measurable disease and no m…

This study is testing a new type of hip resurfacing device made entirely of ceramic, designed for people with hip osteoarthritis, necrosis, or dysplasia. The goal is to see if it is as safe and effective as existing metal-on-metal devices, but without releasing metal ions into th…

This phase 3 trial is testing whether ropeginterferon alfa-2b, a biologic drug, can help control blood cell counts and symptoms in adults with early or low-risk primary myelofibrosis, a bone marrow disorder. Participants receive either the drug or a placebo every two weeks for up…

This phase 1 trial is testing an experimental pill called flonoltinib maleate in people with certain bone marrow tumors, including myelofibrosis, polycythemia vera, and essential thrombocythemia. The drug targets two proteins involved in abnormal blood cell growth. The study aims…

This phase 3 trial tests whether taking tranexamic acid (TXA) by mouth for an extended period after total knee replacement can improve recovery. TXA is already used during surgery to reduce bleeding, but its benefits when continued afterward are unclear. The study will compare di…

This study follows people with knee osteoarthritis who receive one of two total knee replacement designs: a cruciate-retaining (CR) or a posterior-stabilized (PS) implant. The goal is to compare how well each design relieves pain, restores function, and holds up over time. Resear…

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adal…

This trial is testing an experimental drug called flonoltinib in people with intermediate to high-risk myelofibrosis, a type of bone marrow cancer that often causes an enlarged spleen. Participants will be randomly assigned to receive either a low or high dose of flonoltinib, or …

This study tests a drug called sonelokimab in 960 adults with active psoriatic arthritis who have not used biologic treatments before. The goal is to see if it reduces joint pain and swelling better than a placebo. Participants receive injections over several months, and research…

This study is testing a device called KeriFuse® that is implanted into the finger joint to fuse the bones together. It is for people with arthritis in the last joint of the finger or thumb. The goal is to see if it reduces pain and successfully fuses the joint within three months…

This early-phase study tests a new drug called INCB160058 in adults with myeloproliferative neoplasms, a group of rare blood cancers. The main goal is to check the drug's safety and how the body processes it. About 186 participants will receive the drug to find the right dose and…

This trial is testing two different cup designs for total hip replacement, both paired with the same stem, to see which one gives patients better hip function and less pain. About 120 people with hip arthritis or related conditions will be randomly assigned to receive either the …

This study follows 299 people who received the Smith+Nephew Porous Total Knee System, a titanium knee replacement for severe arthritis. The goal is to see if the implant reduces pain, improves movement, and lasts at least two years without needing revision surgery. Participants a…

This trial compares two types of knee replacement implants: one that keeps the posterior cruciate ligament (CR) and one that does not (PS). Both are implanted using a computer-assisted personalized technique that aims to restore the knee's natural alignment. The study includes 14…

This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to…

This early-stage trial is testing a new drug called INCA033989, alone or with an existing drug ruxolitinib, in 225 people with myeloproliferative neoplasms (a group of blood cancers). The main goal is to check safety and find the best dose. Participants must have a specific genet…

This trial compares two surgical procedures for people with painful thumb base osteoarthritis that hasn't improved with conservative care. One procedure removes the entire trapezium bone, while the other removes only a small portion to create a narrow gap. The study will track pa…

This trial tests whether injecting platelet-rich plasma (PRP) into the thumb joint can reduce pain and improve function in people with thumb base osteoarthritis. Participants are randomly assigned to receive either PRP or a saline placebo injection, and neither they nor the resea…

This study tests a new medicine called INZ-701 in babies up to 1 year old who have a rare genetic condition (ENPP1 deficiency) that causes severe hardening of the arteries and bone problems. The goal is to see if the drug can raise a key substance in the blood, improve survival, …

This trial is testing an oral drug called AG-120 (ivosidenib) in adults with myelodysplastic syndrome (MDS) or a related early form of leukemia that carries a specific IDH1 gene mutation. The drug is designed to block the mutated enzyme that drives abnormal blood cell growth. Res…

This study tests a new way to treat adults with a specific type of leukemia (Ph+ ALL) that has come back or not responded to treatment. The approach combines low-intensity chemotherapy with two targeted drugs, ponatinib and blinatumomab, to kill cancer cells and boost the immune …

This trial compares two surgical approaches for a common type of ankle fracture. Half of the participants will have the posterior bone fragment fixed with a plate or screw, while the other half will not. The goal is to see if fixing this fragment makes the ankle joint stable enou…

This early-phase trial tests a drug called DR-18 in 40 adults with acute myeloid leukemia or myelodysplastic syndrome whose cancer returned or persisted after a stem cell transplant. DR-18 is a modified immune protein designed to boost the body's natural defenses against cancer c…

This trial is testing an oral drug called enasidenib (AG-221) in people with myelodysplastic syndrome (MDS) who have a specific genetic change called an IDH2 mutation. The drug is designed to block the mutated enzyme and help restore normal blood cell production. Participants rec…

This study tests a new 3D-printed implant for adults with hip dysplasia, a condition where the hip socket doesn't fully cover the thigh bone, causing pain and gait problems. Ten participants aged 18-45 will receive the implant to see if it is safe and helps improve hip function a…

This study tests a new drug called INZ-701 in up to 16 infants (up to 1 year old) with rare genetic conditions (ENPP1 or ABCC6 deficiency) that cause dangerous calcium buildup in arteries and other problems. The main goal is to check the drug's safety and how the body handles it,…

This trial is testing whether a single injection of micrografts made from a patient's own ear cartilage can improve symptoms and knee function in adults with moderate knee osteoarthritis. The micrografts are prepared from a small ear cartilage sample using a special device, witho…

This early-phase trial tests two oral drugs, olutasidenib and ziftomenib, together in 20 adults with a specific form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The first part finds a safe dose; the second checks if that dose helps control the…

This early-phase trial tests a single intravenous dose of LY-M001 gene therapy in 9 children (ages 6 to 17) with type 1 Gaucher disease. The goal is to see if it is safe and can improve key symptoms like liver size and blood markers. Researchers will monitor participants for side…

This study tests two drugs, vorinostat and azacitidine, together in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination is safe and effective. About 135 participants will take part in this early-…

This study tests a specific timing of chemotherapy drugs (busulfan and fludarabine) before a donor stem cell transplant, followed by cyclophosphamide after the transplant, to treat high-risk blood cancers like leukemia and lymphoma. The goal is to reduce the chance of the transpl…

This study tested a simplified care plan for people with acute promyelocytic leukemia (APL), a rare blood cancer. The goal was to see if following easy-to-use guidelines and getting support from APL experts could lower the number of deaths soon after starting treatment. About 200…

This study is for adults with a specific type of acute myeloid leukemia (CD123+ AML) who cannot receive standard strong chemotherapy. It tests a new drug, tagraxofusp, added to two other drugs (venetoclax and azacitidine) to see if it helps more people achieve complete remission.…

This study tests whether adding the drug selinexor to standard chemotherapy can help older adults with untreated acute myeloid leukemia (AML) live longer and achieve remission. About 57 participants will receive either standard chemo alone or chemo plus selinexor, followed by mai…

This trial tests whether an investigational drug called SHR-1314 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. Participants receive either SHR-1314 or a placebo injection over 24 weeks, with follow-up for safety. The study aims to s…

This study tests two strategies to keep acute myeloid leukemia (AML) from coming back in people aged 65 and older who have achieved remission after initial treatment. One group receives a stem cell transplant, while the other continues on a maintenance drug combination of azaciti…

This study tests an oral drug called ONC201 in people whose acute leukemia or high-risk myelodysplastic syndrome (MDS) has returned or not responded to standard treatments. The trial has two phases: Phase I finds the safest dose, and Phase II checks if the drug shrinks or control…

This early-stage trial is testing an experimental oral drug, TYRA-200, in people with advanced bile duct cancer (intrahepatic cholangiocarcinoma) and other solid tumors that have specific changes in the FGFR2 gene. The study aims to find a safe and effective dose and to see wheth…

This study tests whether adding the targeted therapy cabozantinib to standard immunotherapy (nivolumab and ipilimumab) helps people with advanced kidney cancer live longer. About 1,175 adults with kidney cancer that has spread will receive either the usual treatment or the usual …

This trial tests whether adding pelvic floor muscle training to standard scoliosis-specific exercises can better reduce spine curvature in adolescents with idiopathic scoliosis. Participants aged 10-18 with mild to moderate curves will be randomly assigned to either exercises alo…

This trial tests whether a 12-week program of physical therapy or home exercises can reduce pain and improve shoulder function in adults with glenohumeral arthritis, compared with no treatment. Participants are randomly assigned to one of three groups: supervised physical therapy…

This study tests an experimental drug, HT-6184, in adults with a bone marrow disorder called myelodysplastic syndrome (MDS) who have low red blood cell counts (anemia). The goal is to see if the drug can improve blood counts and reduce the need for transfusions. Participants take…

This early-stage trial is testing a new treatment called CC-97540, which uses a patient's own immune cells modified to target and destroy faulty immune cells. It is for people with severe forms of lupus, myositis, scleroderma, or rheumatoid arthritis that have not improved with s…

This study tests whether adding an immunotherapy drug (pembrolizumab) to standard chemotherapy (azacitidine and venetoclax) can improve outcomes for older adults with newly diagnosed acute myeloid leukemia (AML) who cannot have intensive chemo. About 60 participants will be rando…

This study tests whether adding ASTX727 to the standard drug dasatinib can better control chronic myeloid leukemia (CML) in newly diagnosed patients. About 70 adults with a specific genetic marker (Philadelphia chromosome) will receive both pills. The goal is to see if the combin…

This trial is testing whether a single injection of stem cells taken from a patient's own belly fat can ease the pain and improve the function of knees damaged by osteoarthritis. Half of the participants will receive the stem cell treatment, while the other half will get a placeb…

This study is testing an oral medication called upadacitinib in children with polyarticular juvenile idiopathic arthritis (JIA), a condition causing joint inflammation. The goal is to understand how the drug moves through the body, its safety, and how well children tolerate it. P…

This trial investigates whether ropeginterferon alfa-2b can help people with polycythemia vera, a condition where the body makes too many red blood cells. The study will compare the drug to standard care, which includes phlebotomy (removing blood) and aspirin. About 70 adults wit…

This trial tests whether a structured 16-week corrective exercise program can improve spinal alignment in adolescents aged 10–18 with mild to moderate scoliosis (Cobb angle 10°–40°). Participants are randomly assigned to either the corrective program or standard physiotherapy. Th…

This trial compares two types of knee replacement implants in people aged 75 and older: a standard metal-backed component and a cheaper all-polyethylene (plastic) one. The goal is to see if the all-polyethylene implant performs as well in terms of pain relief, movement, and how l…

This phase I trial is testing whether a combination of three treatments — an experimental drug called elimusertib, precise radiation therapy, and the immunotherapy pembrolizumab — can shrink or stabilize recurrent head and neck cancer that cannot be removed by surgery. The study …

This study tests a new radioactive drug called [177Lu]Lu-PentixaTher in people with acute leukemia that has come back or not responded to standard treatments. The drug seeks out and delivers radiation directly to leukemia cells that have a specific marker (CXCR4). The main goals …

This study looks at how well a surgical technique called AMIC holds up ten years after repairing cartilage damage in the ankle. Researchers are checking whether the pain relief and function patients gained in the first few years remain stable or fade over time. About 40 people wh…

This trial compares two treatments applied during surgery to help heal jaw bone damage caused by bisphosphonates or similar drugs. One is an oxygen-based gel, the other is a membrane made from the patient's own platelets. Researchers will measure how completely the bone and soft …

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This study looks at whether a drug called abaloparatide can improve bone quality in people with osteoporosis who need spine surgery. About 60 participants will take the drug for 3-6 months before and after surgery. The goal is to see if it reduces complications like broken hardwa…

This trial investigates whether a single or repeat infusion of zoledronate, or daily oral alendronate, can maintain the bone density improvements achieved with denosumab in postmenopausal women with osteoporosis. Participants who have been on denosumab for at least three years wi…

This phase 3 trial compares the biologic drug P1101 (ropeginterferon alfa-2b) against the standard drug anagrelide in people with essential thrombocythemia, a rare blood cancer that causes too many platelets. The study enrolls adults who have not responded well to the first-line …

This study tests an experimental oral drug called LY3410738 in people with advanced blood cancers such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) that have specific IDH1 or IDH2 gene mutations. The drug is designed to block the mutated IDH proteins that he…

This early-phase trial tests a new type of immune cell therapy called WU-CART-007 for people with certain blood cancers, including acute myeloid leukemia and T-cell lymphoma, that have come back or not responded to treatment. The therapy uses donor cells that are genetically modi…

This phase 3 trial tests whether cabergoline, a drug already used for hormone-producing pituitary tumors, can shrink or slow the growth of non-functioning pituitary adenomas (NFPAs). These tumors do not produce excess hormones, so current treatment is limited to surgery or radiat…

This study tests whether giving patients hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) after an umbilical cord blood stem cell transplant helps the donated stem cells grow faster. The trial enrolls people with blood cancers like leukemia or lymphoma who lack …

This trial tests whether giving a low-dose infusion of desmopressin (dDAVP) during surgery for complex brain tumors around the pituitary gland can prevent dangerously high sodium levels (hypernatremia) in the first 24 hours after surgery. High sodium can cause brain bleeding, sei…

This phase 1 trial tests whether the drug tagraxofusp can help prevent relapse in people with certain blood cancers (acute myeloid leukemia, myelodysplastic syndrome, myelofibrosis, or chronic myelomonocytic leukemia) who have recently received a stem cell transplant. Participant…

This study tests the drug anakinra in Chinese patients with two related inflammatory conditions: Systemic Juvenile Idiopathic Arthritis (SJIA) in children and Adult-Onset Still's Disease (AOSD) in adults. Participants receive a daily injection under the skin for 48 weeks. The goa…

This study follows 300 people who receive a hip replacement using either the Vivacit-E or Longevity liner, both made of a special plastic designed to last longer. The goal is to see how well these liners hold up over time, measuring how many are still in place without needing rep…

This phase 3 study tests whether the drug luspatercept can help people with myelofibrosis-related anemia become independent of red blood cell transfusions. Participants are adults with myelofibrosis who are already taking a JAK inhibitor and need regular transfusions. The study c…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This trial tests whether adding two drugs—vorinostat and low-dose azacitidine—after a stem cell transplant can help prevent relapse in children with certain myeloid cancers. The study includes children aged 1 to 21 with acute myeloid leukemia or related conditions. Researchers ar…

This study tests whether a home exercise program using a blood pressure cuff to partially restrict blood flow can help people regain leg muscle strength and walking ability after a total knee replacement. Participants will do light exercises three times a week for ten weeks. The …

This study is for people with FSHD, a genetic disease that causes muscle weakness. It tests the long-term safety and how well the body tolerates a drug called AOC 1020, given through a vein. About 84 adults who completed a previous study will take part. The main goal is to check …

This trial tests whether injections of platelet-rich fibrin (iPRF), made from a patient's own blood, can reduce pain and improve jaw function in people with mild to moderate temporomandibular joint (TMJ) degeneration. Forty-two adults with TMJ arthritis or osteoarthritis will rec…

This phase 2 trial tests whether adding lab-grown umbilical cord blood cells (dilanubicel) to a standard cord blood transplant helps people with blood cancers like leukemia recover their blood and immune cells faster. Participants receive chemotherapy and radiation to prepare the…

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This study compares two types of shoulder replacement surgery—Total Shoulder Arthroplasty (TSA) and Reverse Total Shoulder Arthroplasty (RTSA)—in people aged 65 and older with advanced shoulder osteoarthritis. Participants are randomly assigned to one of the two procedures. The g…

This trial compares two speech therapy approaches for Cantonese-speaking children and teens aged 4 to 17 who have cleft palate with or without cleft lip. One method focuses on practicing individual sounds, while the other targets the overall sound system. The goal is to see which…

This study follows 59 adults who received a specific shoulder replacement stem to see how well it works and holds up over 10 years. Researchers will track implant survival, side effects, and patient-reported pain and function. The goal is to confirm the device is safe and effecti…

This early-stage study tests a new drug called IOA-244 in about 210 adults with advanced or metastatic cancers like lung cancer, melanoma, and lymphoma. The main goal is to see if the drug is safe and tolerable, both alone and combined with other treatments. Researchers also chec…

This study tests whether a short, standardized 4-minute heart-healthy talk is as effective as a full 60-minute personalized session with a dietitian for lowering LDL cholesterol and improving diet. Participants are adults aged 30–80 with rheumatoid arthritis, psoriatic arthritis,…

This study tests a device called the Zimmer Biomet Tether System, which is surgically placed along the spine to correct curvature in children with scoliosis. Unlike traditional spinal fusion, which permanently joins vertebrae, this tethering approach aims to guide growth while pr…

This early-stage trial tests an experimental oral drug called GB3226 in adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The drug works by blocking two pathways that help leukemia cells grow. The study aims to find a safe dose and check f…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This phase I trial tests the safety of adding ruxolitinib to a standard combination of dasatinib and dexamethasone for adults aged 40 and older with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The study starts with a low dose of ruxoli…

This trial tests whether adding a radioactive antibody (90Y-DOTA-anti-CD25 basiliximab) to standard chemotherapy and targeted radiation can better prepare the bone marrow for a stem cell transplant in people with high-risk acute leukemia or myelodysplastic syndrome. The antibody …

This study tests whether eating dried plums (prunes) every day for a year can improve bone density and strength in postmenopausal women with low bone mass. Participants eat either 6 or 12 dried plums daily, plus calcium and vitamin D supplements. Researchers measure changes in bo…

This study tests a surgical technique to restore the natural curve (lordosis) of the lower spine in people who have had a previous spinal fusion that failed or caused ongoing pain. The procedure is done through the same incision used in the prior surgery. Researchers will measure…

This study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…

This study compares two types of implants used in spinal fusion surgery: 3D-printed cages and titanium-coated cages. The goal is to see which leads to better bone fusion and less disability for patients with herniated discs or degenerative spine disease. About 78 adults undergoin…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This study tests a precise radiation method called total marrow and lymphoid irradiation (TMLI) given with two chemotherapy drugs (etoposide and cyclophosphamide) before a donor stem cell transplant. The goal is to safely deliver higher radiation doses to the bone marrow to wipe …

This study tests a single dose of PBGM01, a gene therapy delivered directly into the fluid around the brain and spinal cord, in children with GM1 gangliosidosis. The therapy uses a harmless virus to carry a working copy of the GLB1 gene, which is missing or faulty in these patien…

This trial investigates the best way to treat children with acute myeloid leukaemia (AML) by comparing different chemotherapy drugs and doses. It tests whether adding up to three doses of the targeted drug gemtuzumab ozogamicin to standard chemo is safe and effective. The study a…

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This phase 3 trial compares a two-drug combination (pevonedistat plus azacitidine) against azacitidine alone in 302 older or unfit adults newly diagnosed with acute myeloid leukemia (AML) who cannot have standard intensive chemotherapy. The main goal is to see if the combination …

This study tests an experimental drug called LY2784544 in people with three types of blood cancers known as myeloproliferative neoplasms: polycythemia vera, essential thrombocythemia, and myelofibrosis. The trial enrolls patients who have not responded to, cannot tolerate, or hav…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This study follows 94 people who received the FDA-approved H3 total ankle replacement for arthritis. Researchers will track serious device-related problems and how well the ankle works over 2 to 5 years. The goal is to confirm the device's safety and effectiveness in real-world u…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This early-phase trial tests a reduced-intensity stem cell transplant using a half-matched donor and a drug called cyclophosphamide after the transplant to prevent rejection. The goal is to see if this approach is safe enough for patients with advanced myelofibrosis, a serious bo…

This study provides extended access to the drug momelotinib for 237 people with a type of bone marrow cancer called myelofibrosis. Participants had already been taking momelotinib in earlier studies and had not seen their disease get worse. The goal is to see how safe the drug is…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

This clinical trial compares three different chemotherapy regimens for young adults (ages 18-65) newly diagnosed with low-risk acute myeloid leukemia (AML). One regimen includes a new drug called lisaftoclax combined with standard chemotherapy drugs. The study aims to see which c…

This study tests three different chemotherapy regimens in 450 young adults (ages 15-65) with intermediate- or high-risk acute myeloid leukemia (AML). All regimens include the experimental drug lisaftoclax plus standard chemotherapies. The main goal is to see which combination lea…

This study tests whether injections of platelet-rich plasma (PRP) or stem cells from belly fat can help people with knee osteoarthritis. 160 adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to get PRP, stem cells, both, or a placebo. Researchers wi…

This phase 2 trial tests a combination of six drugs, called the Beach regimen, in 32 adults with relapsed or refractory acute myeloid leukemia (AML). The goal is to see if this mix can bring about remission and improve survival. Participants receive the drugs in a specific schedu…

This phase II trial tests two targeted drugs, vemurafenib and cobimetinib, in 24 people with a rare type of brain tumor called papillary craniopharyngioma that has a specific genetic mutation (BRAF V600E). The drugs work by blocking enzymes that help tumor cells grow. The main go…

This study looks at whether lower doses of the chemotherapy drug CPX-351 can help older patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that have come back or not responded to other treatments. The goal is to control the disease while being gentler o…

This phase 3 study tested whether adding venetoclax to azacitidine helps people with untreated acute myeloid leukemia (AML) who cannot receive standard chemotherapy. About 443 adults took part, with two-thirds receiving the drug combo and one-third getting a placebo plus azacitid…

This phase 2 trial tests an injectable form of methotrexate called FBL-MTX for people with moderate-to-severe rheumatoid arthritis. The drug is designed to deliver methotrexate directly into the body using tiny fat bubbles, which may improve how well it works and reduce side effe…

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This early-phase trial tests a new cell therapy called BEN301 for several autoimmune diseases, including scleroderma and rheumatoid arthritis. The therapy uses specially engineered immune cells (CAR-Treg cells) to calm the overactive immune system. The study involves 24 adults an…

This phase 2 trial tests whether eltrombopag, a drug already approved for other blood disorders, can improve blood cell counts in people with low-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) who have a mutation in the TET2 gene. Participants take…

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This study compares two treatments for end-stage hip osteoarthritis: total hip replacement surgery and progressive resistance training (strength exercises). About 109 adults aged 50 and older with severe hip arthritis will be randomly assigned to one of the two treatments. The ma…

This study looks at whether choosing stem cell donors based on certain genes (KIR) in addition to standard matching can reduce the chance of leukemia returning after a bone marrow transplant. About 511 people with acute myeloid leukemia (AML) are taking part. Doctors will test do…

This study tests whether adding the drug itacitinib to the usual two-drug regimen (cyclophosphamide and tacrolimus) can better prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD is a serious complication where donor cells at…

This study tests a stem cell transplant from a matched unrelated donor for people with advanced blood cancers or blood disorders. Patients get chemotherapy and radiation before the transplant to prepare their body, then take drugs to prevent the donor cells from attacking their o…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This early-stage study tested a combination of three immunotherapy drugs (blinatumomab, nivolumab, and ipilimumab) in 28 adults with a severe form of B-cell leukemia that had returned or not responded to prior treatments. The main goal was to find safe doses and identify side eff…

This study aimed to see if giving special immune cells (γδ T cells) after a stem cell transplant could help prevent leukemia from coming back in high-risk patients. It was planned for adults aged 18-65 with acute myeloid leukemia. However, the study was withdrawn before any parti…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This phase 3 trial tests whether a new oral drug called TLL-018 works better than tofacitinib for active rheumatoid arthritis. The study includes 459 adults aged 18-65 who have not responded well to or cannot tolerate biologic treatments. Participants take either TLL-018 or tofac…

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This early-stage trial tests two new targeted drugs (AG-120 and AG-221) given alongside standard chemotherapy for people with a specific genetic form of acute myeloid leukemia (AML). The study includes about 153 adults with newly diagnosed AML that has an IDH1 or IDH2 mutation. T…

This early-phase trial tests whether adding high-dose vitamin C (ascorbate) to the chemotherapy drug gemcitabine can help adults with advanced soft tissue or bone sarcoma that cannot be surgically removed or has spread. About 30 participants will receive the combination intraveno…

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This study looks at how well the Insignia Hip Stem works and how safe it is for people needing a total hip replacement. It includes 313 adults with conditions like hip arthritis or fractures. Researchers will check implant survival and hip function for up to 10 years after surger…

This study tests whether a Fracture Liaison Service (FLS) helps people aged 50 and older who have had a hip or spine fracture. Half of the 400 participants get the FLS, which includes bone health checks, medication guidance, diet and exercise advice, and regular phone follow-ups …

This study aims to find the safest and most effective initial chemotherapy for older adults (60-75) newly diagnosed with acute myeloid leukemia who can handle strong treatment. About 90 participants will be randomly assigned to one of two drug combinations or a standard treatment…

This study tests a personalized treatment for age-related osteoporosis using the drug teriparatide. Researchers aim to match treatment to each patient's bone turnover rate using simple blood tests, avoiding the need for painful bone biopsies. The trial involves 60 adults aged 45 …

This phase 2 trial tests two different chemotherapy combinations in adults aged 60-75 with acute myeloid leukemia (AML). One group gets a standard drug combo plus venetoclax (DAV/IAV), while the other gets a newer combo with homoharringtonine (HAV). The goal is to see which regim…

This study tests whether taking teriparatide (a bone-building drug) for one month before lumbar fusion surgery helps surgeons place screws more securely in patients with osteoporosis. About 192 participants will be randomly assigned to receive either the drug or no pretreatment. …

This study looks at whether taking teriparatide (Forteo) for 24 months can improve bone structure in 100 men and women with osteoporosis. Researchers will use a special CT scan to see changes in bone thickness and microarchitecture at the wrist and shin. The goal is to understand…

This early-phase study tests a new drug called cusatuzumab alongside usual treatments for adults with acute myeloid leukemia (AML) who cannot have intensive chemotherapy. The main goal is to check the safety and side effects of the combination. About 61 participants will receive …

This study looks at how teriparatide, a bone-building drug for severe osteoporosis, affects bone structure in postmenopausal women. Researchers will use a special scanner to see changes in bone thickness and tiny connecting rods at the wrist and ankle over 24 months. The goal is …

This study tests an experimental drug called imetelstat in 46 adults with high-risk myelodysplastic syndromes or acute myeloid leukemia that did not improve after standard therapy. The goal is to see if the drug can improve blood cell counts and control the disease. Participants …

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This study compares a single-stage surgery using implants coated with an antibiotic-loaded hydrogel to the standard two-stage surgery for treating chronic hip prosthesis infections. The single-stage approach aims to remove the infected implant and place a new one in the same oper…

This study was designed to test the safety and best dose of the drug revumenib in children and young adults with certain types of leukemia (ALL, AML, or mixed phenotype) after they have received a stem cell transplant. The goal was to see if revumenib could help prevent the cance…

This clinical trial is testing different treatment strategies to improve outcomes for older adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) who are getting a stem cell transplant. The study compares a new pre-transplant drug (Vyxeos) with stan…

This study tests a new way to do stem cell transplants for children and young adults (up to age 22) with blood cancers like leukemia. Doctors remove certain immune cells from donated stem cells to lower the risk of graft-versus-host disease, a serious complication. The goal is to…

This study tests a new way of giving two drugs—venetoclax and azacitidine—to adults with acute myeloid leukemia (AML) who are not healthy enough for standard chemotherapy. Instead of the usual 7 days of azacitidine, this approach uses only 5 days per cycle to try to reduce infect…

This phase 2 trial tests a new targeted drug called sonrotoclax (taken as a pill) combined with standard chemotherapy in 47 adults newly diagnosed with acute myeloid leukemia (AML). The treatment plan is adjusted based on each patient's genetic risk and response. The goal is to s…

This study tests a surgically implanted bionic hand system for people who have lost an arm below the elbow. The device aims to connect directly to nerves so users can control it more naturally and even feel sensations. Fifteen participants will be followed to see if the system is…

This study looks at whether people with chronic myeloid leukemia (CML) can stop taking their daily targeted therapy (TKI) without the cancer coming back. It compares two approaches: stopping the drug suddenly after a year of normal dosing, versus slowly reducing the dose over a y…

This study checks the long-term safety of RGX-111, a gene therapy for people with MPS I (a rare genetic disorder). It follows 21 participants who already received the therapy in an earlier trial. Researchers will monitor side effects and measure changes in thinking and behavior o…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This phase II trial tests the drug decitabine in 21 patients with advanced myelofibrosis, a bone marrow cancer that causes scarring and anemia. The goal is to see if decitabine can improve blood counts and reduce the need for transfusions. Researchers are also monitoring side eff…

This phase 3 trial tests whether a combination of pentoxifylline (a muscle pain drug) and vitamin E can help heal jaw bone damage caused by osteoporosis or cancer treatments. About 100 people with medication-related jaw bone death will receive either the drug combo plus standard …

This study is checking how well a new hip replacement part (the HYPE stem) works and lasts over 10 years. About 180 people with hip disease from arthritis or injury will get the implant. Doctors will use X-rays and surveys to see if the implant stays firmly in place and helps red…

This study planned to test a new hip replacement device (the HYPE stem) in people with hip arthritis or other hip damage. The goal was to see how well the device works and if it is safe. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study follows 194 people who received the Comprehensive Nano shoulder device to replace their shoulder joint due to arthritis, bone death, or deformity. Researchers will track how long the implant lasts and how well patients can use their shoulder over 10 years. The goal is …

This study looks at two types of hip implants used in total hip replacement for people with metastatic bone disease (cancer that has spread to the hip bone). The goal is to see if a newer implant design (dual mobility) is as good as a standard one (constrained liner) at preventin…

This study tests a treatment using stem cells from donated umbilical cords for people with early-stage osteonecrosis (bone death) of the hip. The goal is to see if the cells are safe and can help control the disease, possibly avoiding the need for hip replacement. The study was s…

This study follows 200 people who received a new type of ankle replacement designed to attach better to bone and wear out more slowly. Researchers will track pain, function, and how long the implant lasts over time. The goal is to see if this improved device helps people with sev…

This study follows 757 people who received the Persona Partial Knee system, a device used to replace only the damaged part of the knee. The goal is to see how long the implant lasts and how well patients function afterward. Participants have knee arthritis or related conditions a…

This study follows 118 people who already received a LEGION knee implant during total knee replacement surgery. Researchers will check how well the implants hold up over 10 years by measuring implant survival and patient quality of life using questionnaires. The goal is to confir…

This early-phase study tests a three-drug combination (navitoclax, venetoclax, and decitabine) in adults and teens with acute myeloid leukemia that returned or didn't respond to previous treatment. The goal is to find the safest dose and see if the combo can shrink or control the…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tests a procedure for people with early-stage osteonecrosis (bone death) of the hip. Doctors drill into the hip bone, inject a concentrated sample of the patient's own bone marrow, and add a special bone graft material called Genex. The goal is to see if this helps bon…

This study tests whether adding venetoclax to standard chemotherapy (cytarabine) can help adults with acute myeloid leukemia (AML) stay in remission longer. About 232 participants who are already in remission will receive either the combination or chemo alone. The main goal is to…

This study tests whether injecting a concentrated sample of a patient's own bone marrow into the knee right after meniscus surgery can slow down or prevent arthritis. One hundred adults with a torn meniscus will receive either the bone marrow injection or a saltwater placebo, and…

This study tests a stem cell transplant method for people with blood cancers like leukemia or lymphoma. The approach uses chemotherapy, total body radiation, and a drug called cyclophosphamide after the transplant to prevent graft-versus-host disease, where donor cells attack the…

This study follows 9 people with Fanconi Anemia who already received a gene therapy that adds a working FANCA gene to their blood stem cells. Researchers will check their health and blood counts for 15 years to see if the treatment remains safe and keeps working. No new treatment…

This study tests an experimental drug called BL-B01D1 in 27 adults with advanced chordoma, a rare bone cancer. The goal is to see if the drug can shrink tumors or slow disease progression. Participants receive the drug intravenously, and researchers monitor safety and effectivene…

This early-phase trial tests the safety of Allocetra-OTS, a cell therapy made from donor immune cells, injected into the knee joint of 18 people with end-stage osteoarthritis who are candidates for surgery. Researchers will monitor side effects and measure pain relief using a sta…

This study tests a combination of three drugs (homoharringtonine, venetoclax, and azacitidine) in 40 adults newly diagnosed with a rare and aggressive leukemia called mixed-phenotype acute leukemia (MPAL). The goal is to see if this drug combo can safely help more patients achiev…

This study compares stem cell transplants from two types of donors for people with leukemia or myelodysplastic syndromes (MDS): younger non-family members (age 40 or under) and older first-degree relatives (over 50). The goal is to see which donor leads to better overall survival…

This early-phase study tests the safety of specially engineered immune cells (armored CAR T cells) in people with certain blood cancers that have not responded to standard treatments. The cells are made from the patient's own blood and designed to better target and attack cancer …

This study tests whether a medicine called Amicar (EACA) can reduce blood loss in children aged 2 to 36 months who need skull reconstruction for a condition called craniosynostosis. The trial involves 22 children, half receiving Amicar and half receiving a placebo (salt water). T…

This study tests whether giving antibiotics directly into the bone during a standard cleaning surgery can better control joint infections and reduce the need for additional major surgeries. About 100 adults with infected knee or hip replacements will receive this targeted antibio…

This study tests whether adding everolimus to the existing drug lonafarnib can better control progeria, a rare disease that causes rapid aging in children. About 80 children with confirmed progeria will take both pills by mouth. The first part finds the safest dose of everolimus,…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This study is following 110 people who received a Tornier HRS shoulder replacement to see how well it improves pain and function. Participants have conditions like arthritis, fractures, or rotator cuff tears. The goal is to collect long-term safety and performance data for regula…

This study looks at 40 adults with osteoporosis who already completed a year of treatment with either Alendronate or Teriparatide. In this follow-up, participants will switch to the other drug for another year to see which works better for bone loss. The goal is to find a more pe…

This study tests an experimental drug called quizartinib, given with chemotherapy, for children and young adults (ages 1 month to 21 years) whose acute myeloid leukemia (AML) has returned or not responded to treatment. The goal is to see if the combination is safe and can help co…

This phase II trial tests whether adding the immunotherapy drug durvalumab to precise radiation (SBRT) can better control prostate cancer that has returned and spread to a few spots (oligometastases). About 96 men with hormone-sensitive prostate cancer will be randomly assigned t…

This study is observing about 881 people with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis who are taking Remsima (a biologic drug) either as a shot under the skin or through an IV. The goal is to track any serious side effects over time. Resear…

This phase 1 trial tests whether the oral drug Inqovi (decitabine/cedazuridine) can help prevent myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) from returning after a stem cell transplant. About 22 adults who have had a reduced-intensity transplant will …

This phase 2 study tests whether the drug ruxolitinib can help prevent acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) from coming back after a stem cell transplant. About 64 older adults in remission will take ruxolitinib as maintenance therapy. The goal is to see…

This study follows 16 people who previously received ICM-203 (a gene therapy) or a placebo for knee osteoarthritis. Researchers will track delayed side effects and measure changes in knee pain and function over time. The goal is to understand the long-term safety and effectivenes…

This study tests a new gene therapy for boys with Hunter syndrome, a genetic disorder that damages the brain and body. The therapy uses the child's own blood stem cells, modified to produce the missing enzyme, and aims to stop disease progression. Five boys aged 3 to 22 months wi…

This study tests the drug regorafenib in 30 patients aged 9 to 21 with bone cancers (osteosarcoma or Ewing sarcoma) that have not responded to standard therapy. The goal is to see if the drug can help control the disease and improve survival, while also checking its safety. The a…

This early-stage trial tests the safety and best dose of combining two drugs—everolimus and midostaurin—for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or is hard to treat. The drugs work by blocking faulty signals that help cance…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This study follows 73 people who received a shoulder replacement using the Anatomical Shoulder Domelock System. The goal is to see how well the device works and how safe it is over 10 years. Participants have conditions like arthritis or avascular necrosis and have not improved w…

This study follows 200 adults with ankle arthritis who received the INFINITY ankle replacement. Researchers will check how long the implant lasts and monitor for any problems like loosening or cysts over 10 years. The goal is to see if this device works as well as other similar i…

This study tests an oral drug called emavusertib (CA-4948) in adults with acute myeloid leukemia (AML) or a high-risk bone marrow disorder (MDS) that have not responded to or returned after prior treatment. The goal is to find the safest and most effective dose and to see if the …

This study followed 413 people with hip arthritis who received a new type of hip replacement called the OXINIUM DH system. The goal was to see how well the implant worked and how safe it was over 10 years. Researchers checked pain, movement, and whether the implant stayed in plac…

This study tests an oral enzyme called SYN-004 in adults who have received a stem cell transplant and need intravenous antibiotics for fever. The enzyme is designed to break down antibiotics in the gut, protecting the natural bacteria there. Researchers will check safety, whether…

This study tests a drug called vosoritide in 56 children with short stature caused by certain genetic conditions. The drug targets the growth plate to help children grow faster. Participants are observed for 6 months, then treated with daily injections for 12 months to check safe…

This study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to help prevent the donor cells from attacking the patient's body. The goal is to see if th…

This study tests a gene therapy called RGX-111 for people with MPS I, a rare genetic disorder that damages the brain and body. The therapy delivers a working copy of the missing IDUA gene directly into the fluid around the brain. The trial aims to check if the treatment is safe a…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This trial is testing a new imaging tracer called FLT, which is used with a PET scan to measure how fast tumors are growing. The study includes people with various cancers or those awaiting a biopsy for a suspicious mass. The goal is to see if FLT PET imaging can help find and di…

This trial tests whether an AI tool called DeepBMD can identify people at high risk for osteoporosis using CT scans they've already had for other reasons. Researchers will compare the AI's findings with the standard bone density test (DXA) to see if it's accurate. If it works, th…

This study tests whether a radioactive tracer called 124I-evuzamitide can detect amyloid deposits in the heart and elsewhere in people aged 60 and older who have lumbar spinal stenosis or carpal tunnel syndrome. Participants will receive a single dose of the tracer and undergo a …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests a 3D body scanner called NSite to see if it can reliably monitor scoliosis in teenagers. Thirteen teens with scoliosis will be scanned by three different users to check if the results are consistent. If it works, this device could offer a radiation-free way to tr…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study tests whether a new type of PET/CT scan, using a radioactive tracer called 68Ga-DOTATOC, can find neuroendocrine tumors (NETs) and similar tumors more safely and accurately than current imaging methods. About 800 people with known or suspected NETs will receive the sca…

This study looks at 174 adults with painful joint replacements who may have a chronic infection. Researchers are testing a combination of advanced lab tests, imaging, and tissue sampling to see which methods best detect the infection. The goal is to create a more reliable diagnos…

This study looks at whether a special type of PET scan (FDG-PET) can more accurately detect bone infections (osteomyelitis) in people with diabetic foot disease. Researchers will compare the scan results with MRI and follow patient outcomes to see how well it works. The goal is t…

This trial tests whether an educational program on sustainable diet and breastfeeding, given before delivery, can increase the number of mothers who exclusively breastfeed for up to six months. The study includes 429 pregnant women and also measures the environmental impact of di…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This study tests a program called PREVENT designed to reduce hip fractures in long-term care homes. The program uses a risk calculator based on residents' health records to identify those at high risk, then trains healthcare staff on the latest fracture prevention recommendations…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This study aimed to see if a surgical procedure called scleral buckling could prevent retinal detachment in people with Stickler syndrome, a genetic condition that raises the risk of vision loss. The plan was to treat one eye in patients aged 5 to 35 who had already lost vision i…

This study tests whether a supervised resistance exercise program can reduce the risk of osteoporosis and osteoarthritis in women aged 50-70 who have gone through menopause. Participants will do leg and core exercises twice a week for 30-40 minutes. Researchers will measure chang…

This study tests whether a weekly dose of everolimus (a drug that targets aging pathways) and/or a fun exercise program called 'Football Fitness' can prevent the rapid bone loss that happens after menopause. 136 healthy women aged 45-60 will be assigned to one of four groups: exe…

This study tests whether a daily capsule containing a heat-killed probiotic (LDL557) can improve joint discomfort and inflammation in 100 older adults with early knee or hip arthritis. Participants take either the probiotic or a placebo for a period, and researchers measure chang…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This study tests whether a specific ultrasound-guided nerve block can reduce pain after elective lower back surgery better than the usual method of injecting pain medicine into the wound. Adults aged 18-65 undergoing surgery for conditions like a herniated disc or spinal stenosis…

This study follows 166 people aged 45 and older who received the Superion IDS implant for lumbar spinal stenosis, a condition that narrows the spine and causes leg pain. The implant is designed to limit certain movements that worsen symptoms. Researchers are checking if patients …

This study tests two treatments for tennis elbow (lateral epicondylitis) in 60 adults aged 18-65. One group gets ultrasound-guided dry needling, the other gets shock wave therapy, both once a week for five weeks. Everyone also does a home exercise program. The goal is to see whic…

This phase II trial is testing whether an experimental lotion called ASKC200 can reduce pain in people with knee osteoarthritis. About 175 adults aged 40 to 80 with knee pain lasting at least six months will be randomly assigned to receive one of two strengths of ASKC200, a stand…

This study looks at whether adding a low-dose dexmedetomidine infusion to standard pain management can lower the amount of narcotics needed and reduce side effects like nausea and itching in teenagers having posterior spinal fusion for scoliosis. About 160 adolescents with idiopa…

This phase 3 trial tests whether an 800 mg modified-release ibuprofen tablet can reduce chronic knee pain from osteoarthritis better than a placebo. About 500 adults with knee osteoarthritis will take either the long-acting ibuprofen or a placebo daily for 12 weeks. Researchers w…

This trial tests whether suzetrigine (Journavx), a newly approved non-opioid pain medication, can effectively control pain after thumb basal joint replacement surgery. One hundred adults aged 40 to 80 will receive suzetrigine plus acetaminophen for five days after surgery, and th…

This study tests whether blocking certain arteries in the knee (geniculate artery embolization) can reduce pain and the need for opioid painkillers in people with knee osteoarthritis. Twelve participants will receive the procedure and be followed for a year with MRI scans and pai…

This pilot study tests whether a minimally invasive technique called percutaneous needle electrolysis can reduce groin pain and improve hip function in male ice hockey players aged 18 to 21. Six players will receive three ultrasound-guided treatments to the hip capsule. Researche…

This study tests a single injection of Hydrogel OA 2% in 20 adults with knee osteoarthritis. The goal is to see if the gel is safe and tolerable over 13 weeks to 12 months. Participants must be 35–75 years old with a BMI between 20 and 35.

This trial tests a minimally invasive surgery for cervical spinal stenosis, a condition where the spinal canal narrows and presses on the spinal cord. Instead of the standard approach that uses metal screws and rods, surgeons will only remove the tissue causing the compression th…

This pilot study tests a WeChat-based program that provides daily mental health check-ins and tailored coping strategies for people with ankylosing spondylitis who also have mild-to-moderate depression or anxiety. Thirty-six adults will be split into two groups: one receives the …

This study looks at whether a structured physiotherapy and exercise program can improve pain, strength, balance, and quality of life in one person with melorheostosis, a rare bone condition. The patient will do exercises three times a week for eight weeks, along with education ab…

This study compares two robotic-assisted systems (Velys J&J and Cori S&N) for total knee replacement in 200 people with severe knee arthritis. Researchers will measure knee alignment, movement, and patient-reported outcomes like pain and function. The goal is to see if one robot …

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study tests a wearable device called TracPatch that sticks to the shin after total knee replacement surgery. The patch tracks knee motion, temperature, and steps for six weeks, sending data to doctors. Researchers want to see if this real-time monitoring helps patients regai…

This study planned to test whether a nerve block in the cheek area could reduce the need for morphine after cleft palate repair in children aged 5 months to 12 years. The experimental group would have received the nerve block, while the control group would not. However, the study…

This pilot study explores whether a 7-day fast followed by 11 weeks of a plant-based diet can reduce skin and joint symptoms in people with psoriasis and psoriatic arthritis. Researchers will also look at changes in gut bacteria and overall quality of life. The study involves 30 …

This study looks at whether using a blood flow restriction cuff during physical therapy can help people with tennis elbow feel less pain and recover faster. The trial plans to enroll 250 adults aged 18 to 65 with confirmed tennis elbow. Participants will either receive standard p…

This Phase 2 trial tests whether a paste made with ejiao (a traditional Chinese ingredient) can reduce knee pain in people with osteoarthritis. Sixty adults with knee pain will use either the ejiao paste, a similar paste without ejiao, or a synthetic control. The study aims to se…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study looks at whether adding desensitization exercises to the usual hand rehab program can help rheumatoid arthritis patients who have central sensitization—a condition where the nervous system is extra sensitive to pain. About 81 adults with mild-to-moderate RA will be spl…

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patient…

This study compares two methods of giving the pain medicine EXPAREL during knee replacement surgery. About 40 adults will receive the medicine either as a targeted block or as local infiltration. Participants will report their pain levels and any extra pain medicines they need. T…

This study looks at whether starting to walk earlier after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain and improve function in people with knee osteoarthritis. About 72 participants will either start partial weight bearing at 2 weeks or wait until …

This study looks at 600 hip or knee replacement patients to compare three different wound closure products: Sylke adhesive dressing, Exofin skin glue, and Suture Strip Plus. The goal is to see which method causes the fewest allergic skin reactions and gives the best scar appearan…

This study looks at whether giving vitamin D supplements to women with depression and low vitamin D levels can change their brain waves. Researchers will measure brain activity using a non-invasive EEG scan before and after supplementation. The trial includes 34 women aged 20-40 …

This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to bette…

This study tests whether doing guided exercises at home via video calls can reduce pain and improve movement in people with hip or knee osteoarthritis. 110 participants will either receive remote exercise sessions or standard education about their condition. The goal is to see if…

This study compares two types of blood flow restriction therapy (using a cuff to limit blood flow during exercise) against standard moderate strength training in 75 people with knee osteoarthritis. Participants will do supervised exercises twice a week for 8 weeks. The goal is to…

This study looks at whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the knee can reduce pain and improve movement in people with knee osteoarthritis. The trial involves 110 adults over 35 with knee arthritis. Researchers are…

This study looks at whether starting palliative care early can help adults with aggressive leukemias or myelodysplastic syndrome (MDS) have a better end-of-life experience. Researchers will compare where patients die (home, hospice, or hospital) and how often they need hospital c…

This study tests whether small meals containing dairy or banana can reduce bone breakdown in postmenopausal women with osteopenia (low bone density). Thirteen women will eat five different test meals or fast, then have blood samples taken over six hours to measure markers of bone…

This study was designed to see if an artificial intelligence app could help people with knee osteoarthritis do their exercises correctly at home. It planned to compare the app group to a group using a paper exercise booklet. The study was withdrawn before any participants were en…

This study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…

This study looks at whether a 12-week group exercise program called Les Mills Thrive can change how muscles work and improve strength, balance, and symptoms in 42 older adults with knee osteoarthritis. Participants will attend weekly classes that include flexibility, strength, an…

This study looks at whether special high-dissolving foods can improve feeding quality of life for children aged 6 months to 18 years after craniofacial surgery. Half of the 160 participants will receive these foods after surgery, while the other half will follow standard care. Re…

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol,…

This study tests whether a special traction pad placed between the patient and the surgery table can reduce numbness in the groin area after hip arthroscopy. About 120 patients having hip surgery at Northwestern Memorial Hospital will be asked about numbness and difficulty urinat…

This study tests whether a combination of a structured exercise program and a plant-based anti-inflammatory diet (the New Nordic Diet) can improve quality of life for people with mild to moderate knee osteoarthritis. Sixty participants will follow the training and diet plan, and …

This study compares three ways to manage the airway during sinus surgery: a laryngeal mask, a breathing tube, and a breathing tube with lidocaine to numb the throat. Researchers want to see which method causes the least coughing and helps patients wake up more calmly. The trial i…

This study tested whether an ozone oil-based gel can reduce pain and prevent dry socket after lower wisdom tooth removal, compared to a standard CHX gel. One hundred patients received both treatments in separate sessions. Pain levels and dry socket occurrence were recorded for 48…

This study tests whether adding ultrasound-guided nerve blocks before hip or knee replacement surgery can reduce pain and opioid use compared to standard pain management. 400 adults with osteoarthritis will be enrolled. The goal is to improve recovery and reduce side effects like…

This study compares two common procedures for chronic back pain caused by a slipped disc or narrowed spine: a steroid injection and a nerve-targeting radiofrequency treatment. Researchers will track pain levels in 200 adults right after the procedure and three weeks later. The go…

This study looks at whether a smaller dose of steroid injected into the knee with ultrasound guidance works as well as a larger dose given without ultrasound. The goal is to reduce side effects while still easing pain. About 140 people with knee osteoarthritis will receive one of…

This study tests three wearable devices designed to help children aged 7-16 with juvenile idiopathic arthritis (JIA) manage their condition. The tools include a heating wrap for pain, a gamified physio tool, and a classroom communication aid. Twenty-five children will use the dev…

This study tests whether a short course of oral methylprednisolone (a steroid) after knee replacement surgery can lower pain, reduce the need for strong painkillers, and lessen nausea. About 116 adults with knee osteoarthritis are taking part. The goal is to see if this simple me…

This study tests whether a nerve block combined with a thigh tourniquet can reduce pain in the back of the knee after total knee replacement. About 60 adults aged 40-85 will participate. The goal is to improve comfort and reduce the need for strong painkillers.

This small pilot study is testing whether using heat (radiofrequency ablation) to disable a nerve in the heel can relieve chronic pain from plantar fasciitis or heel spurs. The 31 participants have had pain for over 6 months and tried at least four other treatments without succes…

This study looks at whether adding HyalganBio injections to a physical exercise program helps people with shoulder osteoarthritis move better and feel less pain. About 72 adults aged 45 to 85 with chronic shoulder pain will be split into two groups: one gets three weekly injectio…

This small study tests a procedure called radiofrequency ablation for people with chronic shoulder pain that hasn't improved with standard treatments like physical therapy or injections. The treatment uses heat to calm the nerves that send pain signals from the shoulder joint. Te…

This study was designed to test whether a new gel called Hydrogel OA 2% could safely relieve knee osteoarthritis pain better than a standard treatment. It planned to enroll adults with knee OA and give them one injection, then track side effects and symptom improvement for 26 wee…

This early study tests an injection called Allocetra for osteoarthritis at the base of the thumb. The trial includes 46 adults aged 40 and older whose pain hasn't improved with standard treatments. Researchers are checking if the injection is safe and whether it can reduce pain a…

This study tests whether a structured, supervised exercise program is safe and feasible for people with painful non-spine bone metastases who have just had palliative radiotherapy. Twenty participants will follow an 8-week exercise plan plus a short maintenance period. Researcher…

This study tests whether combining different doses of esketamine and dexmedetomidine can improve pain relief after scoliosis correction surgery. About 312 adults will receive one of several drug combinations alongside standard painkillers. The goal is to reduce pain and the need …

This study tests whether doing special flexibility exercises for 6 months before spinal fusion surgery helps teens with scoliosis. Researchers want to see if it leads to fusing fewer vertebrae, better curve correction, shorter surgery, and less time in the hospital. Forty teens a…

This study compares two types of pain-relief pumps placed inside the knee joint after total knee replacement. 65 adults having outpatient knee surgery will be randomly assigned to receive either standard pain management or one of two pump brands. The goal is to see which approach…

This study compares a new opioid-free pain management plan to the usual opioid-based approach for teenagers (ages 10-20) having spinal fusion surgery for scoliosis. The opioid-free plan uses a mix of numbing injections and non-opioid medications like gabapentin, ibuprofen, and ac…

This study tests a 32-week smart community resistance training program for adults aged 60 and older with primary osteoporosis. Participants use elastic bands and a smart bracelet to guide their workouts, while researchers measure changes in bone density and physical function comp…

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower…

This study was designed to see if giving nitrous oxide (laughing gas) helps pregnant women feel less pain when a balloon is placed to start labor. It planned to compare nitrous oxide with plain oxygen. However, the study was withdrawn before any participants were enrolled, so no …

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study looks at whether core stability exercises or ankle and foot strengthening exercises can help people with knee osteoarthritis feel better. About 100 adults aged 40 and older with moderate knee osteoarthritis will take part. The goal is to see which type of exercise redu…

This pilot study tests whether the anti-inflammatory drug naproxen can reduce pain in people with knee osteoarthritis. Twenty participants will take naproxen or a placebo in a crossover design, meaning each person tries both treatments at different times. The study measures daily…

This study looks at whether whole-body vibration training can improve body composition, muscle strength, walking speed, and pain in 30 older adults with knee osteoarthritis and sarcopenic obesity. Participants will do vibration exercises, and researchers will measure changes in p…

This study looks at whether a 6-day course of oral steroids after orthopedic surgery can help reduce pain, nausea, and improve movement. About 500 adults having common surgeries like joint replacement or fracture repair will be randomly assigned to receive either standard care or…

This study tests whether adding blood flow restriction (a technique that gently limits blood flow to the legs) to walking on an anti-gravity treadmill can better reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 45-80 with knee arthritis wi…

This study planned to test an injection of doxycycline into the knee area to reduce chronic pain in people with osteoarthritis who cannot have surgery. The trial was withdrawn before enrolling any participants, so no data was collected. The goal was to see if the procedure could …

This study from the University of Pittsburgh is looking at how well people recover after total knee replacement surgery. It compares two types of surgery: one done with a robot's help and one done by hand. Researchers will follow 30 people who are already scheduled for knee repla…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study looks at how well the heart, lungs, and muscles work together in people who have had a stem cell transplant. Researchers want to find out why transplant survivors have a higher risk of heart disease. About 350 adults with blood cancers will be followed for two years af…

This study is investigating how common muscle loss, known as sarcopenia, is in people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will measure body composition using DXA scans and track hospital stays, disease progression, and survival. The goal is to see…

This study tests whether a special website and video coaching for parents can help children aged 6-12 who had leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking due to treat…

This study aims to find genetic changes that may cause sporadic chordoma, a rare bone cancer. Researchers will collect saliva and medical records from 188 patients across the U.S. and Canada who are the only ones in their family with chordoma. No treatment is given; the goal is t…

This study is collecting blood, bone marrow, and tissue samples from 5,000 people with blood cancers like leukemia and lymphoma. Researchers will analyze the samples to find genetic abnormalities that cause cancer cells to grow. The goal is to understand why these cancers develop…

This study looks back at 10 years of medical records from a scoliosis referral center to see how frequently adults with scoliosis who had surgery also develop restrictive breathing problems or signs of pulmonary hypertension on echocardiography. By analyzing data from 174 patient…

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study evaluates whether a single dose of TQ05105, a JAK inhibitor being developed for myelofibrosis, affects the heart's electrical activity (QT interval) in healthy Chinese adults. Sixty participants receive TQ05105, placebo, and moxifloxacin (a positive control) in a cross…

This study follows children aged 6 to 17 with active juvenile enthesitis-related or psoriatic arthritis who are being treated with secukinumab. Researchers will track how long children stay on the drug, how much their symptoms improve, and whether they achieve remission. The goal…

This study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …

This study looks at whether a special type of testing, called leukemia profiling, can help find personalized treatment options for children and young adults up to age 30 with recurrent, refractory, or high-risk leukemias. Researchers analyze the genetic changes in each patient's …

This study looks at how physical, psychological, and movement-related factors work together in adults with chronic knee pain. By tracking these factors over time, researchers hope to understand why pain experiences differ between people. The goal is to develop practical tools tha…

This study looks at records from over 500,000 Medicare beneficiaries with rheumatoid arthritis or ankylosing spondylitis who had major orthopedic procedures like joint replacements or spine surgery between 1999 and 2015. Researchers want to understand how often complications happ…

This registry follows patients who receive donor cartilage or meniscus transplants for joint defects in the knee, hip, ankle, or shoulder. Researchers are collecting long-term data on pain, function, and whether the grafts need revision or fail over time. The goal is to understan…

This early-stage study in 16 healthy adults checks if taking a common stomach acid drug (rabeprazole) changes how the body absorbs a new experimental drug (TQ05105) being developed for myelofibrosis. Participants take TQ05105 alone and later with rabeprazole to compare drug level…

This study evaluates a blood test that uses genetic and epigenetic information to help doctors predict which rheumatoid arthritis medication will work best for each patient. Researchers will collect blood samples from 1,410 adults with rheumatoid arthritis who have not responded …

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study follows children and young adults (up to age 35) with brain or skull base tumors who are scheduled to receive radiation therapy to the brain. Researchers use brain scans to track changes in brain structure and volume over time. They also measure thinking skills, hormon…

This study investigates how people with axial spondyloarthritis (axSpA) experience sudden worsening of symptoms, known as flares. Over 12 months, 40 participants use a digital diary to track symptoms, diet, lifestyle, and self-management strategies, and provide blood samples duri…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study tests whether a simple isometric (static) hand exercise can change how people with rheumatoid arthritis feel pain. Researchers will measure pain tolerance, pressure thresholds, and muscle oxygen levels in 66 adults. The goal is to see if this type of exercise can help …

This study tests whether a simple mathematical formula, applied to routine CT scans, can accurately predict the size of a bone defect that will be created during surgery to remove a bone tumor. Accurate prediction could help surgeons select the right-sized donor bone graft before…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study follows 30 adults aged 45-80 who are having spinal fusion surgery for spondylolisthesis. Researchers will use CT scans to measure changes in the bone graft placed between vertebrae over time. The goal is to develop an objective way to assess whether the bones have fuse…

This study looks at how patients with advanced blood cancers (like acute myeloid leukemia) who are not eligible for a cure, along with their nurses and doctors, feel about the benefits of blood transfusions. Researchers will give questionnaires before each transfusion to compare …

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study examines how often healthcare workers in a hospital's intensive care unit (ICU) experience physical, verbal, or sexual assaults from patients or their relatives. Researchers will review medical records of 865 adults who were in the ICU and had a reported incident of vi…

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The go…

This was a planned French study to collect information on chronic myeloid leukemia (CML) in young adults aged 18 to 30 who were treated with tyrosine kinase inhibitors. The goal was to describe their diagnosis, treatment choices, side effects, and quality of life. However, the st…

This study looks at whether a 3-month non-surgical program—including patient education, supervised exercise, and diet counseling—can help people with knee osteoarthritis avoid knee replacement surgery while maintaining their quality of life. Researchers will follow 2,500 patients…

This study was designed to see if X-rays taken before knee replacement surgery could reliably show ligament damage in people with knee arthritis. It was an observational study, meaning no treatment was given. However, the study was withdrawn before enrolling any participants, so …

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study uses an iPhone app to track symptoms of psoriasis and psoriatic arthritis in 1,000 adults. Participants complete surveys, take photos of their skin, and use phone sensors to measure joint function. The goal is to see if smartphones can reliably monitor these conditions…

This study follows 600 people with Albright hereditary osteodystrophy, a rare genetic condition affecting bones and hormones. Researchers are looking at how growth hormone treatment affects height and weight in those with a related hormone problem, and also studying thinking and …

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at why some people with early rheumatoid arthritis develop long-lasting chronic pain while others do not. Researchers will use pain sensitivity tests and brain scans to find clues. The goal is to better understand the transition from acute to chronic pain, which …

This study aimed to find out how often chronic sinusitis occurs in children treated for head and neck cancer, and how it affects their quality of life. Researchers planned to compare these children to those treated for cancer elsewhere in the body using a questionnaire called SNO…

This study looks back at medical records of 725 older adults (over 65) with acute myeloid leukemia (AML). Researchers want to see if using a special 'fitness' score to choose treatment leads to longer survival. No new treatments are given; the goal is to learn which treatment app…

This study follows 400 patients for two years after they have endoscopic endonasal skull base surgery (surgery through the nose to reach the base of the skull). The goal is to measure their quality of life and nose function using standard questionnaires. It does not test a new tr…

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This study collects medical information from patients whose cancer has spread to the bone. The goal is to learn more about how cancer affects bones and how to prevent complications like fractures and pain. No extra tests or visits are needed—just data from regular care. The study…

This study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer question…

This study aimed to see if tracking a specific gene mutation (c-Kit) could help predict relapse in acute myeloid leukemia patients. It planned to compare this method with current monitoring techniques. However, the study was withdrawn before enrolling any participants, so no resu…

This study investigates how common spinal nerve pain is in people with ankylosing spondylitis (AS) and whether it affects their sleep. Researchers will use questionnaires to assess pain, sleep quality, quality of life, and fatigue in 292 AS patients. The goal is to better underst…

This study follows 26 people who had hip surgery (periacetabular osteotomy) for hip dysplasia. Researchers want to see how many return to their favorite sports and how well they recover. The study collects data from medical records and patient reports, focusing on pain levels and…

This study looks at nerve-related pain in people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Researchers will use a questionnaire to describe the pain and see how it relates to daily activities. About 130 adults with the condition will take par…

This study tests whether sending a short screening questionnaire directly to people with psoriasis can help detect psoriatic arthritis earlier. 18,000 participants will be randomly assigned to receive the questionnaire or not. Those with high scores will be advised to see a rheum…

This long-term study recruited over 12,000 non-pregnant women in Southampton, UK, and followed about 3,000 of them through pregnancy and their children's growth up to age 19. Researchers are tracking body composition, nutrition, asthma, and heart health to understand how a mother…

This study looks at whether it is safe to wait before giving a second round of chemotherapy to adults newly diagnosed with acute myeloid leukemia (AML), even if a mid-treatment bone marrow biopsy shows some remaining disease. About 60 participants will receive standard first chem…

This study looks at bone erosions in the finger joints of 9 people with rheumatoid arthritis. Researchers use advanced imaging and tissue analysis to see tiny blood vessels and bone structure. The goal is to better understand how joint damage happens, which could lead to better m…

This study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…

This early study tests a radioactive imaging agent called 89Zr-Cimzia in 10 people with rheumatoid arthritis. The goal is to see if it can highlight inflamed joints on a PET scan, comparing painful joints to pain-free ones. The study is currently suspended, and it is exploratory,…

This early-stage study tests whether the cholesterol drug atorvastatin can reduce levels of a faulty protein (p53) in people with various cancers, including solid tumors and leukemia. About 50 participants will take atorvastatin for 1 to 4 weeks before their planned surgery or tr…

This study aimed to compare knee movement in people who had one of two different total knee replacements. Researchers planned to measure how the knee bends and shifts during activities like stepping up and deep knee bends. The study was withdrawn before any participants were enro…

This study follows 450 infants and their families from birth to age 12 to learn how a child's biology and home environment work together to shape eating habits and growth. Researchers collect samples, measurements, and surveys at regular visits. The goal is to understand what inf…

This study tests whether sending information letters to doctors and patients after a fracture can improve osteoporosis care. Over 4,200 older adults in Manitoba who had a hip, spine, arm, or wrist fracture are included. The goal is to see if these notifications increase bone dens…

This study looks at how different eating habits—like being a vegetarian, eating fish, or drinking alcohol—might affect a person's chance of developing rheumatoid arthritis. Researchers are using data from half a million UK adults aged 40 to 70. They are not testing a new treatmen…

This study is testing whether a new type of MRI can detect changes in the brain that lead to memory and thinking problems in people with multiple sclerosis (MS). Researchers will scan 75 adults with MS and give them thinking and memory tests. The goal is to see if the new MRI mea…

This study reviewed records of 166 knee replacement patients who received a nerve block for pain. Researchers compared pain scores 6-24 hours after the block wore off between two groups: one that received extra education about pain management before surgery and one that did not. …

This study looks at how the quality and movement of thigh muscles relate to pain, daily function, and quality of life in women with knee osteoarthritis. About 58 women aged 40-70 will have a painless ultrasound of their thigh muscles and fill out questionnaires. The goal is to be…

This study compares robot-assisted spine surgery to the traditional method in 300 adults needing spinal fusion. The goal is to see if the robot helps place screws more accurately, reduces complications, and improves patient outcomes. Participants are randomly assigned to either r…

This study aims to develop a new way to measure how well the sinuses work in people with chronic sinusitis. About 30 adults with chronic sinusitis and a recent bacterial infection will take the drug ivacaftor. The main goal is to see if a special test can detect changes in sinus …

This study is tracking 120 people who received a HYPE SCS hip stem during total hip replacement. Researchers will monitor how long the implant lasts, how satisfied patients are, and any complications over 5 years. The goal is to confirm the device is safe and works as intended in…

This study looks at how a knee condition called osteochondritis dissecans (OCD) affects the mental health of young athletes aged 11 to 19. Researchers will measure stress and depression levels in 120 patients as they go through standard treatment, either surgery or non-surgical c…

This study follows about 190,000 Korean radiation workers to see if low-dose radiation exposure over time increases the risk of cancer and other diseases. Researchers will link national health records to track health outcomes. The goal is to better understand the long-term effect…

This study tests whether a special type of X-ray called DXA, taken while lying down, can measure spine curves as well as standard standing X-rays in people with scoliosis. About 20 participants will have both types of images taken, and researchers will compare the results and ask…

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study follows 60 people with lower-risk myelodysplastic neoplasms (MDS) who need regular red blood cell transfusions. Over 6 months, participants use a smartphone app to answer weekly quality-of-life questions and take photos of their fingernails or eyelids. Researchers aim …

This study follows 25 adults with rheumatoid arthritis for one year to see how their blood samples relate to changes in disease activity. The goal is to find early warning signs of a flare. Participants give blood at several visits while their joint swelling and inflammation are …

This study watches 24 adults who are getting standard neck fusion surgery with a special device called the BEE HA cage. The goal is to see how well the cage helps with pain and function over time. No new treatment is tested—just careful tracking of normal surgery results.

This study aims to develop a new way to measure how the spine moves during walking in children, both healthy and those with scoliosis. Researchers will use a special camera system and reflective markers placed on the skin to track movement. The goal is to create a reliable and ea…

This study looks at whether two types of hormonal birth control pills (LF111 and drospirenone) affect bone density in women aged 14 to 45. Over 1,500 participants will have their bone density measured after 12 months and compared to women using non-hormonal birth control. The goa…

This study checks whether two easy-to-use risk calculators (OST and MORES) can accurately predict osteoporosis in Turkish men aged 50-75, compared to the standard DEXA bone density scan. Researchers will enroll 140 men to see how sensitive and specific these tools are. If they wo…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study looks for a biomarker to identify people at risk of bone loss from glucocorticoid medications like prednisolone. 36 healthy volunteers will take either prednisolone or a placebo for seven days. Researchers will measure bone turnover markers in blood and collect bone, m…

This study is testing whether a computer tool called MEKANOS can better predict the risk of hip fractures in people with Fibrous Dysplasia or McCune-Albright Syndrome. Researchers will take CT scans of the femur and use the tool to calculate bone strength. The goal is to improve …

This study looks at how well treatments for childhood hip conditions (like hip dysplasia and Perthes disease) work over the long term. Researchers at Mayo Clinic are following 500 adults who were treated for these conditions as children. They will check how many needed another su…

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study follows 248 adults receiving a CoreHip hip replacement to see how their hip function, pain, and leg length change over time. Participants are treated as part of routine care, and no extra tests or treatments are given. The goal is to collect real-world data on the impl…

This study follows nearly 2,000 adults with spinal deformity (curved spine) to compare outcomes between those who have surgery and those who do not. Researchers track X-rays, pain levels, and quality of life over time. The goal is to learn which approach leads to better long-term…

This study looks at whether people with Fabry, Gaucher, or Hunter disease are more likely to continue their IV treatment when it's given at home versus at a hospital. Researchers will review existing data from 222 patients in Mexico. No new treatments are given; the goal is to un…

This study investigates why some people develop chronic sinusitis with nasal polyps, focusing on how epigenetic changes and viruses might trigger the disease. Researchers will analyze tissue samples from 60 participants, including patients with active disease, those in remission,…

This study is testing a new blood test called AlloHeme that measures how much of a patient's own cells remain after a bone marrow transplant. The goal is to see if this test can predict whether the cancer (acute leukemia or myelodysplastic syndrome) will come back. About 307 adul…

This study follows 1500 patients with pituitary gland disorders to see how they fare over time, whether treated with medication, surgery, or just monitoring. Researchers will track tumor regrowth after surgery to find clues that predict recurrence. The goal is to learn, not to te…

This study follows about 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. Researchers will check for long-term side effects and overall survival for up to 15 years after treatment. No new treatment is given—this is just observat…

This study looks at three different knee replacement designs: one that keeps the ACL, one that substitutes for it, and one that sacrifices it. Researchers want to see which design gives the best function, pain relief, and satisfaction in 75 people with severe knee arthritis. Part…

This study examines how adrenomedullin, a natural protein, affects leukemia stem cells in patients with acute myeloid leukemia (AML). Researchers will collect bone marrow and blood samples from 72 newly diagnosed AML patients to measure adrenomedullin levels and study its effects…

This study looks at 500 adults having pituitary tumor surgery through the nose. Researchers want to find out who gets headaches soon after surgery and build a tool to predict that risk. Participants report their pain daily and fill out surveys for up to 3 months after surgery.