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Can a new Non-Opioid drug replace opioids for Post-Surgery pain?

NCT ID NCT07723352

Symptom relief Sponsor: Rothman Institute Orthopaedics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether suzetrigine (Journavx), a newly approved non-opioid pain medication, can effectively control pain after thumb basal joint replacement surgery. One hundred adults aged 40 to 80 will receive suzetrigine plus acetaminophen for five days after surgery, and their pain levels will be tracked. The goal is to see if this drug can provide relief without the need for opioid painkillers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a non-opioid pain medication called suzetrigine (Journavx), taken as a 100 mg loading dose then 50 mg every 12 hours for 5 days, plus acetaminophen
What this could lead to
If effective, suzetrigine could offer a way to manage post-surgical pain without relying on opioids, reducing the risk of addiction and side effects.
What could go wrong
This is a small, single-arm trial with no comparison group, so results may not prove suzetrigine is better than standard care. Pain relief varies widely, and some people may still need opioids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants Undergoing thumb basal joint arthroplasty (BJA) at Rothman Orthopaedic Institute

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 40-80 years. * Undergoing thumb basal joint arthroplasty (BJA) * Able to provide informed consent. * Willing to comply with the study procedures. Exclusion Criteria: * History of substance abuse or chronic opioid use. * Known allergies to acetaminophen, oxycodone, or suzetrigine. * Severe renal or hepatic dysfunction * Estimated glomerular filtration rate less than 15 ml/min/1.73m\^2 * History of kidney transplant * Child-Pugh Class C * History of liver failure * Active hepatitis that can adversely influence hepatic function * Has had prior surgery on the study hand within the last 6 months * Is currently pregnant, planning to be pregnant, or breastfeeding * Use of strong or moderate CYP3A inhibitors or inducers, or medications known to interact with suzetrigine * Currently using a prescription pain medication other study medications

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hand Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Joint replacement Joint replacement surgery Postoperative pain Thumb basal joint osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rothman Orthopaedic Institute

    Philadelphia, Pennsylvania, 19107, United States

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