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Can an extra nerve block cut opioid use after knee replacement?

NCT ID NCT07803887

Symptom relief Sponsor: Antalya Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This trial tests whether adding a nerve block at the back of the knee to the standard adductor canal block reduces pain and opioid use after total knee replacement. Adults scheduled for knee replacement under spinal anesthesia will receive either the standard block alone or the standard block plus the extra block. Researchers will measure total opioid use over the first 48 hours after surgery, along with pain scores, muscle strength, recovery quality, and side effects. The goal is to see if the combined approach improves pain relief and speeds recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultrasound-guided nerve blocks: an adductor canal block with or without a biceps femoris short head block, using bupivacaine
What this could lead to
If adding the biceps femoris short head block works, it could offer a way to better control pain after knee replacement while reducing opioid use and speeding recovery.
What could go wrong
This is a single-center trial, and the extra block may not meaningfully improve pain or could carry rare risks like nerve damage or bleeding. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 122 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled for elective primary unilateral total knee arthroplasty under spinal -anesthesia. * American Society of Anesthesiologists (ASA) physical status I-III. * Body mass index (BMI) \<40 kg/m². * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Refusal to participate or inability to provide informed consent. * Body mass index 40 kg/m2 or higher. * ASA physical status IV or V. * Known allergy or hypersensitivity to local anesthetics, opioids, or other study -medications. * Pregnancy or breastfeeding. * Uncontrolled psychiatric disease or severe anxiety interfering with study participation. * Pre-existing neuromuscular disease or peripheral neuropathy involving the operative limb. * Chronic opioid use or opioid dependence. * Chronic pain syndrome requiring regular analgesic therapy. * Severe hepatic or renal insufficiency. * Contraindications to spinal anesthesia or peripheral nerve block, including -coagulopathy, thrombocytopenia, local infection at the injection site, or patient refusal. * Planned bilateral or revision total knee arthroplasty.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis (OA) Postoperative pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Antalya Training and Research Hospital

    Antalya, Antalya, 07100, Turkey (Türkiye)

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