Predicting pain: a new model may tailor Post-Surgery relief
NCT ID NCT07803575
First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
This study looks at adults having elective abdominal surgery to understand why some need more pain relief than others. Researchers will track pain scores and how often patients use a morphine pump during the first 48 hours after surgery. They aim to build a model that predicts which patients are likely to need extra pain medication. The goal is to help doctors personalize pain management and improve recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Intravenous morphine via patient-controlled analgesia (PCA), given as standard care and observed, not assigned.
- What this could lead to
- If successful, this could help doctors predict which patients need more pain relief after abdominal surgery, enabling more personalized and safer pain management.
- What could go wrong
- This is an observational study, so it cannot prove cause and effect. The model may not work for all patients or hospitals, and results depend on how accurately pain and medication use are recorded.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 65 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adults undergoing elective abdominal surgery under general anaesthesia will be enrolled in this prospective observational cohort study. The study population represents patients experiencing the early postoperative recovery phase, where pain trajectories and analgesic requirements vary substantially between individuals. Participants will be observed during the first 48 hours after surgery to characterise patterns of rescue analgesic use and postoperative pain. The study aims to develop a predictive model of postoperative analgesic requirements by integrating analgesic administration patterns with patient and surgical characteristics. The findings will support a better understanding of individual variability in postoperative pain management and provide a foundation for future personalised analgesic strategies.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged 18-75 years * American Society of Anesthesiologists (ASA) physical status I-III * Elective open or laparoscopic abdominal surgery under general anaesthesia * Expected postoperative ward or high-dependency unit (HDU) stay of ≥ 48 hours * Ability to provide written informed consent in Bahasa Malaysia or English * Ability to comprehend and self-report pain using the Numerical Rating Scale (NRS, 0-10) Exclusion Criteria: * Chronic opioid therapy, defined as regular opioid use for ≥ 4 weeks prior to surgery * Severe hepatic impairment (Child-Pugh Class B or C) or severe renal impairment (eGFR \< 30 mL/min/1.73 m²) * Known allergy or hypersensitivity to morphine or any opioid analgesic * Cognitive impairment (documented diagnosis of dementia or delirium), language barrier, or communication deficit precluding reliable NRS self-report * Documented history of substance use disorder (including opioid use disorder) * Withdrawal of informed consent at any point
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Universiti Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
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