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Comparison of perioperative analgesia nociception index (ANI) between preoperative and postoperative ultrasound-guided transversus abdominis plane Block(TAP block) in laparoscopic cholecystectomy

NCT ID NCT07809009

NEW Sponsor: Pusan National University Yangsan Hospital Source: ClinicalTrials.gov ↗

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First seen Sep 09, 2026 · Last updated Sep 09, 2026

Summary

The goal of this clinical trial is to learn if the timing of ultrasound-guided transversus abdominis plane block (US-TAP block) administration (preoperative vs. postoperative) affects the perioperative analgesia nociception index (ANI) in adult patients undergoing laparoscopic cholecystectomy. The main questions it aims to answer are: * Does the timing of the US-TAP block significantly influence intraoperative ANI values? * Does the difference in US-TAP block timing and subsequent ANI values correlate with actual patient recovery, postoperative pain scores (VAS), and complication rates? If there is a comparison group: Researchers will compare the experimental group (Group A: US-TAP block before surgical incision) to the control group (Group B: US-TAP block after wound closure) to see if early block administration provides superior intraoperative pain suppression and reduces postoperative pain or analgesic consumption. Participants will: * Undergo standard general anesthesia induction and maintenance. * Receive a bilateral US-TAP block with a total of 30 mL of 0.2% ropivacaine, administered either before incision (Group A) or after closure (Group B). * Be monitored via standard monitoring devices alongside an ANI monitor. * Use an intravenous patient-controlled analgesia (IV-PCA) pump for 24 hours after surgery. * Participate in postoperative assessments to measure pain scores (VAS), rescue analgesic consumption, satisfaction, and complications at specific intervals up to 24 hours post-surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled to undergo laparoscopic cholecystectomy. * Aged 19 years or older. * American Society of Anesthesiologists (ASA) physical status I, II, or III. Exclusion Criteria: * Patients who lack the capacity to understand the study examinations or perform the assessment procedures. * Patients with coagulation deficiencies or bleeding disorders. * Patients with cardiac arrhythmias or those with an implanted cardiac pacemaker. * Patients taking medications that affect the autonomic nervous system, including beta-blockers and opioid analgesics. * Patients with surgical scars, active lesions, or anatomical abnormalities at the block site. * Patients with pre-existing neurological deficits or impairment at the block site. * Patients with a known history of allergic reactions or hypersensitivity to ropivacaine or other local anesthetics. * Pregnant or lactating individuals.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laparoscopic cholecystectomy Postoperative pain

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