New study aims to ease Post-Surgery knee pain without opioids

NCT ID NCT07588958

Ongoing Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patients recover faster with less opioid use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine and fentanyl (spinal anesthesia); bupivacaine (genicular nerve block)
What this could lead to: If successful, this could point to a better way to manage pain after knee replacement, helping patients move sooner and use fewer opioids.
What could go wrong: This is a small, early-stage trial with only 42 participants, so results may not apply to everyone. Nerve blocks carry risks like infection or temporary weakness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN AFTER TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

Faculty of Medicine - Zagazig University

Zagazig, Alsharqia, 4115, Egypt

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