New pill could ease arthritis in kids – major trial underway
NCT ID NCT04088396
First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 6 times
Summary
This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to compare results. The goal is to reduce joint inflammation and improve daily life, but ongoing treatment is needed to control the condition.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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9 Eylul University Hospital
Izmir, 35340, Turkey (Türkiye)
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Alder Hey Children's Hospital
Liverpool, L12 2AB, United Kingdom
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Azienda Ospedaliera Spedali Civili di Brescia
Brescia, 25123, Italy
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Azienda Sanitaria Locale n. 2 - Lanciano Vasto Chieti
Chieti, 66100, Italy
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Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli
Palermo, 90127, Italy
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Bristol Royal Hospital for Children
Bristol, BS2 8BJ, United Kingdom
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Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi
Lodz, 91-738, Poland
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Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau
Nîmes, 30029, France
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Centre Hospitalier Universitaire de Poitiers
Poitiers, 86021, France
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Centro Medico Privado de Reumatologia
SAN M. de Tucuman, T4000AXL, Argentina
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Centro Specialistico Ortopedico Traumatologico Gaetano Pini - CTO
Milan, 20122, Italy
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Chiba Children's Hospital
Chiba, 266-0007, Japan
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Clinstile, S.A. de C.V.
México, 06700, Mexico
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Crea de Guadalajara
Guadalajara, 44600, Mexico
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Detska nemocnice FN Brno
Brno, 613 00, Czechia
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Faculdade de Medicina da UNESP
Botucatu, 18618-686, Brazil
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Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Great Ormond Street Hospital For Children NHS Foundation Trust
London, WC1N 3JH, United Kingdom
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Hospices Civils de Lyon - Hôpital Femme Mère Enfant
Bron, 69500, France
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Hospital Infantil Universitario Niño Jesús
Madrid, 28009, Spain
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Hospital Sant Joan de Déu
Esplugues de Llobregat, 08950, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León
Monterrey, 66460, Mexico
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Ramón y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
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Hospital de Clinicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
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Hôpital Universitaire Necker Enfants Malades
Paris, 75015, France
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Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
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IPITEC
São Paulo, 01221-020, Brazil
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IRCCS Istituto Giannina Gaslini
Genova, 16147, Italy
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Institute of Science Tokyo Hospital
Bunkyō, 113-8510, Japan
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Instituto CAICI SRL
Rosario, S2000, Argentina
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Instituto da Crianca do Hospital das Clinicas da FMUSP
São Paulo, 05403-000, Brazil
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Instituto de Investigaciones Clínicas para la Salud
Durango, 34000, Mexico
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Investigacion y Biomedicina de Chihuahua
Chihuahua City, 31000, Mexico
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Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine
Istanbul, 34098, Turkey (Türkiye)
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Kagoshima University Hospital
Kagoshima, 890-8520, Japan
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Kanagawa Children's Medical Center
Yokohama, 232-8555, Japan
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Meir Medical Center
Kfar Saba, 4428164, Israel
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Miyagi Children's Hospital
Sendai, 989-3126, Japan
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Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji
Warsaw, 02-637, Poland
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Osaka Medical and Pharmaceutical University Hospital
Takatsuki, 569-8686, Japan
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Ospedale Infantile Burlo Garofolo
Trieste, 34137, Italy
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Oxford University Hospitals - Nuffield Orthopaedic Centre
Oxford, OX3 7HE, United Kingdom
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Schneider Children's Medical Center
Petah Tikva, 49202, Israel
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Sheba Medical Center
Ramat Gan, 5262100, Israel
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Sheffield Children's Hospital
Sheffield, S10 2TH, United Kingdom
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Sir Ganga Ram Hospital
New Delhi, 110060, India
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UZ Gent
Ghent, 9000, Belgium
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Universidade Federal de Sao Paulo
São Paulo, 04024-001, Brazil
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University of Naples Federico II
Naples, 80131, Italy
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Vseobecna fakultni nemocnice v Praze
Prague, 12808, Czechia
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Wojewódzki Specjalistyczny Szpital Dziecięcy im. św. Ludwika w Krakowie
Krakow, 31-503, Poland
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Yokohama City University Hospital
Yokohama, 236-0004, Japan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New hope for kids with arthritis: Long-Term drug study launches
- New study tracks ilaris use in rare inflammatory diseases across europe
- New arthritis drug trial for kids: could filgotinib help?
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- Scientists launch deep dive into mysterious inflammatory diseases