New pill could ease arthritis in kids – major trial underway

NCT ID NCT04088396

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 6 times

Summary

This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to compare results. The goal is to reduce joint inflammation and improve daily life, but ongoing treatment is needed to control the condition.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • 9 Eylul University Hospital

    Izmir, 35340, Turkey (Türkiye)

  • Alder Hey Children's Hospital

    Liverpool, L12 2AB, United Kingdom

  • Azienda Ospedaliera Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Azienda Sanitaria Locale n. 2 - Lanciano Vasto Chieti

    Chieti, 66100, Italy

  • Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli

    Palermo, 90127, Italy

  • Bristol Royal Hospital for Children

    Bristol, BS2 8BJ, United Kingdom

  • Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

    Lodz, 91-738, Poland

  • Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau

    Nîmes, 30029, France

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, 86021, France

  • Centro Medico Privado de Reumatologia

    SAN M. de Tucuman, T4000AXL, Argentina

  • Centro Specialistico Ortopedico Traumatologico Gaetano Pini - CTO

    Milan, 20122, Italy

  • Chiba Children's Hospital

    Chiba, 266-0007, Japan

  • Clinstile, S.A. de C.V.

    México, 06700, Mexico

  • Crea de Guadalajara

    Guadalajara, 44600, Mexico

  • Detska nemocnice FN Brno

    Brno, 613 00, Czechia

  • Faculdade de Medicina da UNESP

    Botucatu, 18618-686, Brazil

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Great Ormond Street Hospital For Children NHS Foundation Trust

    London, WC1N 3JH, United Kingdom

  • Hospices Civils de Lyon - Hôpital Femme Mère Enfant

    Bron, 69500, France

  • Hospital Infantil Universitario Niño Jesús

    Madrid, 28009, Spain

  • Hospital Sant Joan de Déu

    Esplugues de Llobregat, 08950, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León

    Monterrey, 66460, Mexico

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, 90035-903, Brazil

  • Hôpital Universitaire Necker Enfants Malades

    Paris, 75015, France

  • Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre

    Le Kremlin-Bicêtre, 94270, France

  • IPITEC

    São Paulo, 01221-020, Brazil

  • IRCCS Istituto Giannina Gaslini

    Genova, 16147, Italy

  • Institute of Science Tokyo Hospital

    Bunkyō, 113-8510, Japan

  • Instituto CAICI SRL

    Rosario, S2000, Argentina

  • Instituto da Crianca do Hospital das Clinicas da FMUSP

    São Paulo, 05403-000, Brazil

  • Instituto de Investigaciones Clínicas para la Salud

    Durango, 34000, Mexico

  • Investigacion y Biomedicina de Chihuahua

    Chihuahua City, 31000, Mexico

  • Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine

    Istanbul, 34098, Turkey (Türkiye)

  • Kagoshima University Hospital

    Kagoshima, 890-8520, Japan

  • Kanagawa Children's Medical Center

    Yokohama, 232-8555, Japan

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • Miyagi Children's Hospital

    Sendai, 989-3126, Japan

  • Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji

    Warsaw, 02-637, Poland

  • Osaka Medical and Pharmaceutical University Hospital

    Takatsuki, 569-8686, Japan

  • Ospedale Infantile Burlo Garofolo

    Trieste, 34137, Italy

  • Oxford University Hospitals - Nuffield Orthopaedic Centre

    Oxford, OX3 7HE, United Kingdom

  • Schneider Children's Medical Center

    Petah Tikva, 49202, Israel

  • Sheba Medical Center

    Ramat Gan, 5262100, Israel

  • Sheffield Children's Hospital

    Sheffield, S10 2TH, United Kingdom

  • Sir Ganga Ram Hospital

    New Delhi, 110060, India

  • UZ Gent

    Ghent, 9000, Belgium

  • Universidade Federal de Sao Paulo

    São Paulo, 04024-001, Brazil

  • University of Naples Federico II

    Naples, 80131, Italy

  • Vseobecna fakultni nemocnice v Praze

    Prague, 12808, Czechia

  • Wojewódzki Specjalistyczny Szpital Dziecięcy im. św. Ludwika w Krakowie

    Krakow, 31-503, Poland

  • Yokohama City University Hospital

    Yokohama, 236-0004, Japan

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