New arthritis drug trial for kids: could filgotinib help?

NCT ID NCT06222034

Terminated Disease control Sponsor: Alfasigma S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study is testing the drug filgotinib in children aged 8 to 17 with juvenile idiopathic arthritis (JIA), a condition causing joint pain and swelling. The goal is to see how the drug moves through the body and if it is safe. Ten children with moderate to severe JIA that is not well controlled by current treatments will take filgotinib once daily for several weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: filgotinib (Jyseleca)
What this could lead to: If successful, this could provide a new treatment option for children with juvenile idiopathic arthritis that is not well controlled by current therapies.
What could go wrong: This is a very early (Phase 1) study with only 10 participants, so results may not apply to all children. The drug may cause side effects or not work as well as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

JUVENILE IDIOPATHIC ARTHRITIS

Contacts and locations

Locations

Asklepios Klinik Sankt Augustin GmbH

Sankt Augustin, 53757, Germany
Bicêtre University Hospital

Le Kremlin-Bicêtre, 94270, France
CHU Amiens - Hopital Nord

Amiens, 80054, France
Children's university hospital Charité, Campus Virchow, SPZ

Berlin, 13353, Germany
Great Ormond Street Hospital

London, WC1N 3JH, United Kingdom
Hamburger Zentrum fur Kinder und Jugendrheumatologie

Hamburg, 22081, Germany
Hospital Sant Joan de Deu

Barcelona, 08950, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Malopolskie Badania Kliniczne

Krakow, 30-002, Poland

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