New pill could ease severe childhood arthritis

NCT ID NCT05609630

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This study tests a new oral medication, upadacitinib, in children aged 1 to 17 with active systemic juvenile idiopathic arthritis (sJIA), a rare and serious form of arthritis that can affect the whole body. About 90 participants will receive either upadacitinib or the standard injectable drug tocilizumab for 52 weeks. Researchers will measure how well the treatment controls symptoms like joint pain and fever, and monitor for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: upadacitinib (oral tablet or solution)
What this could lead to: If it works, this could provide a new oral treatment option for children with systemic juvenile idiopathic arthritis, potentially reducing symptoms and improving daily life.
What could go wrong: This is a Phase 3 trial, but upadacitinib is still investigational for this condition. It may not prove more effective than existing treatments, and side effects like infections or allergic reactions are possible.

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Conditions

The condition(s) this trial relates to.

juvenile idiopathic arthritis systemic-onset juvenile idiopathic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

JUVENILE IDIOPATHIC ARTHRITIS

Contacts and locations

Locations

Akademiska Sjukhuset - Uppsala University Hospital /ID# 282653
NOT_YET_RECRUITING

Uppsala, Uppsala County, 751 85, Sweden
Asklepios Klinik Sankt Augustin /ID# 251565
RECRUITING

Sankt Augustin, North Rhine-Westphalia, 53757, Germany
Azienda Ospedaliero Universitaria Meyer /ID# 251775
RECRUITING

Florence, Firenze, 50139, Italy
CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 251769
COMPLETED

Juiz de Fora, Minas Gerais, 36010-570, Brazil
CREA de Guadalajara SC /ID# 252917
RECRUITING

Guadalajara, Jalisco, 44620, Mexico
Centro de Investigaciones Medicas Tucuman /ID# 251781
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Children'S Hospital Of Soochow University /ID# 251755
RECRUITING

Suzhou, Jiangsu, 215025, China
Children's Hospital of Fudan University /ID# 251619
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Childrens National Medical Center /ID# 253344
RECRUITING

Washington D.C., District of Columbia, 20010-2916, United States
Cincinnati Childrens Hospital Medical Center /ID# 251827
RECRUITING

Cincinnati, Ohio, 45229, United States
Gazi University Medical Faculty /ID# 253677
COMPLETED

Ankara, 06560, Turkey (Türkiye)
Great Ormond Street Children's Hospital /ID# 251512
RECRUITING

London, Greater London, WC1N 3HZ, United Kingdom
Hamburger Zentrum fuer Kinder- und Jugendrheumatologie /ID# 251564
RECRUITING

Hamburg, 22081, Germany
Helios Klinikum Berlin - Buch /ID# 279847
RECRUITING

Berlin, 13125, Germany
Hospital Sant Joan de Deu /ID# 251353
RECRUITING

Esplugues de Llobregat, Barcelona, 08950, Spain
Hospital Sao Paulo /ID# 251765
RECRUITING

São Paulo, 04023-062, Brazil
Hospital Universitario y Politecnico La Fe /ID# 251352
RECRUITING

Valencia, 46026, Spain
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 251764
RECRUITING

São Paulo, 05403-000, Brazil
Hospital de Niños de la Santisima Trinidad /ID# 252736
RECRUITING

Córdoba, 5014, Argentina
Hyogo Prefectural Kobe Children'S Hospital - Minatojima /ID# 251649
RECRUITING

Kobe, Hyōgo, 650-0045, Japan
IRCCS Istituto Giannina Gaslini /ID# 251776
RECRUITING

Genoa, Genova, 16147, Italy
Institute of Science Tokyo Hospital /ID# 251505
RECRUITING

Bunkyo-ku, Tokyo, 113-8519, Japan
Instituto CAICI S.R.L /ID# 251448
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 251651
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Istanbul University Istanbul Medical Faculty /ID# 251652
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Landeskrankenhaus Bregenz /ID# 266317
RECRUITING

Bregenz, Vorarlberg, 6900, Austria
Levine Children's Hospital /ID# 253491
COMPLETED

Charlotte, North Carolina, 28203, United States
Linkou Chang Gung Memorial Hospital /ID# 267390
RECRUITING

Taoyuan City, 333, Taiwan
Monash Health - Monash Medical Centre - Clayton /ID# 251691
COMPLETED

Clayton, Victoria, 3168, Australia
National Taiwan University Hospital /ID# 267387
RECRUITING

Taipei, 100, Taiwan
New York Medical College /ID# 253437
RECRUITING

Valhalla, New York, 10595, United States
Niigata University Medical and Dental Hospital /ID# 251538
RECRUITING

Niigata, Niigata, 951-8520, Japan
Osaka Medical and Pharmaceutical University Hospital /ID# 252092
RECRUITING

Takatsuki-shi, Osaka, 569-8686, Japan
Ostersunds Sjukhus /ID# 281645
NOT_YET_RECRUITING

Östersund, Jämtland County, 831 31, Sweden
Phoenix Children's Hospital /ID# 253403
RECRUITING

Phoenix, Arizona, 85016-7710, United States
Queen Silvia Children's Hosp /ID# 251318
RECRUITING

Gothenburg, Västra Götaland County, 416 85, Sweden
Randall Children's Hospital /ID# 251829
RECRUITING

Portland, Oregon, 97227-1654, United States
Royal Children's Hospital /ID# 251663
COMPLETED

Parkville, Victoria, 3052, Australia
Semmelweis Egyetem /ID# 266750
RECRUITING

Budapest, 1085, Hungary
Skane University Hospital Lund /ID# 282573
NOT_YET_RECRUITING

Lund, Skåne County, 224 84, Sweden
St Marianna University School Of Medicine /ID# 251623
RECRUITING

Kawasaki-shi, Kanagawa, 216-8511, Japan
St. Josef-Stift Sendenhorst /ID# 268680
RECRUITING

Sendenhorst, North Rhine-Westphalia, 48324, Germany
The Children's Hospital of Zhejiang University School of Medicine /ID# 251754
RECRUITING

Hangzhou, Zhejiang, 310003, China
The Childrens Hospital of Chongqing Medical University /ID# 251539
RECRUITING

Chongqing, Chongqing Municipality, 400065, China
Umraniye Training and Res Hosp /ID# 251653
RECRUITING

Istanbul, 34764, Turkey (Türkiye)
Universitaetsklinikum Freiburg /ID# 253288
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitair Medisch Centrum Utrecht /ID# 267435
RECRUITING

Utrecht, 3584 CX, Netherlands
Xi'an Children's Hospital /ID# 251693
RECRUITING

Xi'an, Shaanxi, 710054, China

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