Bone-Direct antibiotics may save joint replacements from repeat surgery

NCT ID NCT03713528

ENROLLING_BY_INVITATION Disease control Sponsor: OrthoCarolina Research Institute, Inc. Source: ClinicalTrials.gov ↗

First seen Apr 12, 2026 · Last updated Jun 12, 2026 · Updated 7 times

Summary

This study tests whether giving antibiotics directly into the bone during surgery can better control infections in artificial joints. About 100 adults with infected knee or hip replacements will receive this treatment. The goal is to reduce the chance of infection coming back and avoid the need for more major surgeries.

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Contacts and locations

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Locations

Atrium Mercy Hospital

Charlotte, North Carolina, 28207, United States
Cleveland Clinic Florida

Weston, Florida, 33331, United States
New York University - Langone

New York, New York, 10279, United States
Novant Health Charlotte Orthopedic Hospital

Charlotte, North Carolina, 28209, United States
OrthoCarolina Research Institute/OrthoCarolina

Charlotte, North Carolina, 28207, United States
Rush University

Chicago, Illinois, 60612, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Florida

Gainesville, Florida, 32607, United States
University of Nebraska

Omaha, Nebraska, 68105, United States
University of Utah

Salt Lake City, Utah, 84112, United States

Conditions

Explore the condition pages connected to this study.

JOINT INFECTION