Bone-Delivered antibiotics could spare joint infection patients from repeat surgeries

NCT ID NCT03713528

ENROLLING_BY_INVITATION Disease control Sponsor: OrthoCarolina Research Institute, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving antibiotics directly into the bone during a standard cleaning surgery can better control joint infections and reduce the need for additional major surgeries. About 100 adults with infected knee or hip replacements will receive this targeted antibiotic approach and be followed for one year. The goal is to improve infection cure rates and avoid implant removal.

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Conditions

The condition(s) this trial relates to.

bacterial arthritis periprosthetic joint infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

JOINT INFECTION

Contacts and locations

Locations

Atrium Mercy Hospital

Charlotte, North Carolina, 28207, United States
Cleveland Clinic Florida

Weston, Florida, 33331, United States
New York University - Langone

New York, New York, 10279, United States
Novant Health Charlotte Orthopedic Hospital

Charlotte, North Carolina, 28209, United States
OrthoCarolina Research Institute/OrthoCarolina

Charlotte, North Carolina, 28207, United States
Rush University

Chicago, Illinois, 60612, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Florida

Gainesville, Florida, 32607, United States
University of Nebraska

Omaha, Nebraska, 68105, United States
University of Utah

Salt Lake City, Utah, 84112, United States

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