Bone-Delivered antibiotics may spare joint infection patients from repeat surgeries
NCT ID NCT03713528
First seen Apr 12, 2026 · Last updated Apr 23, 2026 · Updated 3 times
Summary
This study tests a new way to give antibiotics during surgery for infected knee replacements. Instead of standard IV antibiotics, the drugs are delivered directly into the bone around the joint. The goal is to see if this approach can stop the infection from coming back, so patients can avoid needing two more major surgeries to remove and replace the implant. About 100 adults with certain types of knee infections will take part and be followed for one year.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Atrium Mercy Hospital
Charlotte, North Carolina, 28207, United States
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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New York University - Langone
New York, New York, 10279, United States
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Novant Health Charlotte Orthopedic Hospital
Charlotte, North Carolina, 28209, United States
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OrthoCarolina Research Institute/OrthoCarolina
Charlotte, North Carolina, 28207, United States
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Rush University
Chicago, Illinois, 60612, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Florida
Gainesville, Florida, 32607, United States
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University of Nebraska
Omaha, Nebraska, 68105, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
Conditions
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