Does an extra knee ligament procedure lead to arthritis later?

NCT ID NCT06885372

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Western University, Canada Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer questions about knee pain and function. The goal is to help doctors and patients weigh long-term risks when choosing treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lateral Extra-Articular Tenodesis (LET) procedure
What this could lead to: If successful, this study will clarify whether adding LET to ACL reconstruction raises the risk of knee osteoarthritis, helping surgeons and patients make better-informed decisions.
What could go wrong: This is an observational follow-up, not a new treatment test. Results may show no clear link or may not apply to all patients. The study relies on imaging and patient reports, which can vary.

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries lupus erythematosus tumidus osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACL RECONSTRUCTION LET OSTEOARTHRITIS (OA) OF THE KNEE

Contacts and locations

Locations

Banff Sport Medicine Clinic

Banff, Alberta, T1L 1B3, Canada
Fowler Kennedy Sport Medicine Clinic

London, Ontario, N6A 3K7, Canada
Fraser Health Authority

New Westminster, British Columbia, V3L 5P5, Canada
McMaster University

Hamilton, Ontario, L8N 3Z5, Canada
Pan Am Clinic

Winnipeg, Manitoba, R3M 3E4, Canada
Queens University

Kingston, Ontario, K7L 2V7, Canada
University Hospitals Coventry and Warwickshire NHS Trust

Coventry, CV2 2DX, United Kingdom
University of Calgary

Calgary, Alberta, T2N 1N4, Canada

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