Osteoporosis drug could strengthen knee rebuilds

NCT ID NCT05527548

Recruiting now Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether taking alendronate, a drug commonly used for osteoporosis, can improve knee function and stability after anterior cruciate ligament (ACL) reconstruction surgery. About 100 people undergoing their first ACL reconstruction will receive either alendronate or a placebo for a year. Researchers will measure knee stability, bone healing around the graft, muscle strength, and patient-reported symptoms to see if the drug helps recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: alendronate, an oral osteoporosis drug being tested to improve knee healing after ACL reconstruction
What this could lead to: If effective, alendronate could speed up recovery, improve knee stability, and reduce the risk of graft failure after ACL surgery.
What could go wrong: This is a small pilot study, and results may not apply to everyone. Alendronate can cause stomach upset, and its benefit for ACL recovery is unproven.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACL RECONSTRUCTION

Contacts and locations

Locations

Prince of Wales Hospital
RECRUITING

Shatin, Hong Kong

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