Younger donors may improve stem cell transplant success for leukemia patients
NCT ID NCT04547049
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares stem cell transplants from two types of donors for people with leukemia or myelodysplastic syndromes (MDS): younger non-family members (age 40 or under) and older first-degree relatives (over 50). The goal is to see which donor leads to better overall survival. The trial involves 232 participants and uses a standard chemotherapy and transplant procedure. It is currently active but no longer recruiting new participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
stem cell transplant (haploidentical hematopoietic stem cell transplantation)
What this could lead to
If successful, this could show that using stem cells from younger, non-family donors leads to better survival and fewer complications than using older family donors.
What could go wrong
This is a Phase 3 trial, but results may not apply to all patients. Stem cell transplants carry serious risks like infection, graft-versus-host disease, and organ damage.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Affiliated People's Hospital of Ningbo University
Ningbo, China
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The First Affiliated Hospital of Nanjing Medical University
Nanjing, China
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The First Affiliated Hospital of Ningbo University
Ningbo, China
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The First Affiliated Hospital of Soochow University
Suzhou, China
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The First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, China
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Xiangya Hospital Central South University
Changsha, China
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Xinqiao Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University
Chongqing, China
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Zhejiang Provincial People's Hospital
Hangzhou, China