Younger donors may improve stem cell transplant success for leukemia patients

NCT ID NCT04547049

Ongoing Disease control Sponsor: First Affiliated Hospital of Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares stem cell transplants from two types of donors for people with leukemia or myelodysplastic syndromes (MDS): younger non-family members (age 40 or under) and older first-degree relatives (over 50). The goal is to see which donor leads to better overall survival. The trial involves 232 participants and uses a standard chemotherapy and transplant procedure. It is currently active but no longer recruiting new participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stem cell transplant (haploidentical hematopoietic stem cell transplantation)
What this could lead to: If successful, this could show that using stem cells from younger, non-family donors leads to better survival and fewer complications than using older family donors.
What could go wrong: This is a Phase 3 trial, but results may not apply to all patients. Stem cell transplants carry serious risks like infection, graft-versus-host disease, and organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia leukemia mixed phenotype acute leukemia myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA MDS

Contacts and locations

Locations

The Affiliated People's Hospital of Ningbo University

Ningbo, China
The First Affiliated Hospital of Nanjing Medical University

Nanjing, China
The First Affiliated Hospital of Ningbo University

Ningbo, China
The First Affiliated Hospital of Soochow University

Suzhou, China
The First Affiliated Hospital, College of Medicine, Zhejiang University

Hangzhou, China
Xiangya Hospital Central South University

Changsha, China
Xinqiao Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University

Chongqing, China
Zhejiang Provincial People's Hospital

Hangzhou, China

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