Engineered donor cells take aim at tough blood cancers in early trial

NCT ID NCT05377827

Terminated Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This early-phase trial tests a new type of immune cell therapy called WU-CART-007 for people with certain blood cancers, including acute myeloid leukemia and T-cell lymphoma, that have come back or not responded to treatment. The therapy uses donor cells that are genetically modified to target a protein called CD7 on cancer cells, while avoiding attacking each other or causing graft-versus-host disease. The main goals are to check safety and find the best dose, with only 6 participants enrolled so far.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: WU-CART-007 (a type of immune cell therapy made from donor cells, engineered to target CD7 on cancer cells)
What this could lead to: If successful, this could offer a new treatment option for people with hard-to-treat blood cancers that have not responded to standard therapies.
What could go wrong: This is a very early, small Phase 1 trial with only 6 participants, so results may not apply broadly. There are risks of serious side effects, and the therapy may not work or may cause long-term immune problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia adult T-cell leukemia/lymphoma anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma enteropathy-associated T-cell lymphoma extranodal nasal NK/T cell lymphoma hepatosplenic T-cell lymphoma Lymphoma, Extranodal NK-T-Cell mature T-cell and NK-cell non-Hodgkin lymphoma monomorphic epitheliotropic intestinal T-cell lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma primary cutaneous gamma-delta t-cell lymphoma Sezary syndrome T-cell non-Hodgkin lymphoma T-cell prolymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA ADULT T CELL LEUKEMIA ADULT T CELL LYMPHOMA ANAPLASTIC LARGE CELL LYMPHOMA ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA EXTRANODAL NK/T-CELL LYMPHOMA HEPATOSPLENIC T-CELL LYMPHOMA MONOMORPHIC EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA PERIPHERAL T-CELL LYMPHOMA PRIMARY CUTANEOUS GAMMA-DELTA T-CELL LYMPHOMA SEZARY SYNDROME T-CELL NON-HODGKIN LYMPHOMA T-CELL PROLYMPHOCYTIC LEUKEMIA TRANSFORMED MYCOSIS FUNGOIDES

Contacts and locations

Locations

Washington University School of Medicine

St Louis, Missouri, 63110, United States

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