New drug combo aims to tame Cushing's disease with fewer side effects

NCT ID NCT07603466

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cortisol faster, reduce the needed dose of osilodrostat, and lessen side effects like high blood pressure and hormone imbalances.

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Conditions

The condition(s) this trial relates to.

ACTH-dependent Cushing syndrome adrenocortical insufficiency Cushing disease due to pituitary adenoma Hyperandrogenism hypertensive disorder potassium deficiency disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Al-Hassan Metabolism Endocrine and Diabetes Center

    Karbala, Iraq

  • Al-Waffa Specialized Center for Diabetes and Endocrinology

    Mosul, Iraq

  • Faiha Specialized Diabetes, Endocrine, and Metabolism Center

    Basra, 61001, Iraq

  • Najaf Specialized Diabetes and Endocrine Center

    Najaf, Iraq

  • Thi-Qar Specialized Diabetes, Endocrine and Metabolism Center

    Nasiriyah, Iraq