New pill shows promise for hormone disorder

NCT ID NCT05307328

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 31 times

Summary

This study tested an experimental drug called SPI-62 in 26 adults with Cushing's syndrome caused by a non-adrenal tumor. The goal was to see if the drug could lower cortisol levels safely. Participants received either SPI-62 or a placebo for 24 weeks, with an option to continue longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Carol Davila University of Medicine and Pharmacy

    Bucharest, 050474, Romania

  • Clinical Center of Endocrinology and Gerontology, University Hospital of Endocrinology, Medical University Sofia (USHATE)

    Sofia, 1431, Bulgaria

  • Comprehensive and Interventional Pain Management Llp

    Henderson, Nevada, 89052, United States

  • Mayo Clinic Cancer Center (MCCC) - Rochester

    Rochester, Minnesota, 55905, United States

  • Medical University of Plovdiv

    Plovdiv, 4002, Bulgaria

  • Medical University of Sofia

    Sofia, 1431, Bulgaria

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • Oregon Health & Science University (OHSU) - Northwest Pituitary Center

    Portland, Oregon, 97239, United States

  • Southwest General Healthcare Center

    Fort Myers, Florida, 33907, United States

  • St. Joseph's Hospital and Medical Center - Barrow Neurological Institute (BNI) - Pituitary Center

    Phoenix, Arizona, 85013, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Washington University School of Medicine - Center for Advanced Medicine (CAM)

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.