New drug shows promise for cortisol disorder

NCT ID NCT05307328

Completed Disease control Sponsor: Sparrow Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called SPI-62 in 26 adults with Cushing's syndrome caused by a non-adrenal tumor. The goal was to see if SPI-62 could lower cortisol levels safely. Participants received either SPI-62 or a placebo for 24 weeks, with an option to continue longer.

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Conditions

The condition(s) this trial relates to.

ACTH-dependent Cushing syndrome Cushing disease due to pituitary adenoma Cushing syndrome ectopic ACTH secretion syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORTISOL EXCESS CORTISOL OVERPRODUCTION CORTISOL; HYPERSECRETION CUSHING DISEASE DUE TO INCREASED ACTH SECRETION CUSHING'S SYNDROME I ECTOPIC ACTH SECRETION

Contacts and locations

Locations

Carol Davila University of Medicine and Pharmacy

Bucharest, 050474, Romania
Clinical Center of Endocrinology and Gerontology, University Hospital of Endocrinology, Medical University Sofia (USHATE)

Sofia, 1431, Bulgaria
Comprehensive and Interventional Pain Management Llp

Henderson, Nevada, 89052, United States
Mayo Clinic Cancer Center (MCCC) - Rochester

Rochester, Minnesota, 55905, United States
Medical University of Plovdiv

Plovdiv, 4002, Bulgaria
Medical University of Sofia

Sofia, 1431, Bulgaria
Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States
Oregon Health & Science University (OHSU) - Northwest Pituitary Center

Portland, Oregon, 97239, United States
Southwest General Healthcare Center

Fort Myers, Florida, 33907, United States
St. Joseph's Hospital and Medical Center - Barrow Neurological Institute (BNI) - Pituitary Center

Phoenix, Arizona, 85013, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
Washington University School of Medicine - Center for Advanced Medicine (CAM)

St Louis, Missouri, 63110, United States

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