New drug aims to tackle diabetes by targeting stress hormone

NCT ID NCT07296484

Recruiting now Disease control Sponsor: Sparrow Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol levels to see if the drug helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: clofutriben (a drug that blocks an enzyme involved in cortisol production)
What this could lead to: If it works, this could lead to a new treatment option for people with type 2 diabetes who also have high cortisol levels.
What could go wrong: This is a phase 2 trial, so it's still early. The drug may not improve blood sugar control better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cushing syndrome ectopic ACTH secretion syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORTISOL EXCESS TYPE 2 DIABETES

Contacts and locations

Locations

Accellacare Charleston
NOT_YET_RECRUITING

Mt. Pleasant, South Carolina, 29464, United States
Admed Research LLC
RECRUITING

Miami, Florida, 33173, United States
Albany Medical College
NOT_YET_RECRUITING

Albany, New York, 12203, United States
Alliance Clinical - Las Vegas
NOT_YET_RECRUITING

Las Vegas, Nevada, 89108, United States
Alliance Clinical - Lewisville (Epic Clinical Research)
NOT_YET_RECRUITING

Lewisville, Texas, 75057, United States
Alliance Clinical San Diego
NOT_YET_RECRUITING

San Diego, California, 92120, United States
Amicis Research Center- Nordhoff
RECRUITING

Northridge, California, 98433, United States
Arizona Clinical Trials - Broadway
RECRUITING

Tucson, Arizona, 85711, United States
Arizona Clinical Trials - Pecos
RECRUITING

Chandler, Arizona, 85225, United States
Ark Clinical Research - Fountain Valley
RECRUITING

Fountain Valley, California, 92708, United States
Ark Clinical Research - Long Beach
RECRUITING

Long Beach, California, 90815, United States
Chicago Clinical Research Institute
RECRUITING

Chicago, Illinois, 60607, United States
Diabetes & Glandular Disease Clinic, P.A.
RECRUITING

San Antonio, Texas, 78229, United States
Elevate Clinical Research
RECRUITING

Seabrook, Texas, 77586, United States
Elixia SISU BHR - Springfield
RECRUITING

Springfield, Massachusetts, 011030, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30303, United States
Endocrine Associates of Long Island, P.C.
RECRUITING

Smithtown, New York, 11787, United States
Endocrinology Associates, Inc
RECRUITING

Columbus, Ohio, 43201, United States
IACT Health-Brookstone Centre Pkwy
RECRUITING

Columbus, Georgia, 31904, United States
Innovative Research Institute
NOT_YET_RECRUITING

Port Charlotte, Florida, 33952, United States
Iowa Diabetes and Endocrinology Research Center
RECRUITING

West Des Moines, Iowa, 50226, United States
Juno Research, LLC
RECRUITING

Houston, Texas, 77040, United States
Los Angeles Institute for Metabolic Research
RECRUITING

Los Angeles, California, 90015, United States
Lucas Research Inc
RECRUITING

Morehead City, North Carolina, 28557, United States
NOLA Care Clinical Research
RECRUITING

Metairie, Louisiana, 70006, United States
Oakland Medical Research Center
RECRUITING

Troy, Michigan, 48085, United States
PMG Research of Wilmington, LLC
NOT_YET_RECRUITING

Wilmington, North Carolina, 28401, United States
Palm Research Center, Inc.
RECRUITING

Las Vegas, Nevada, 89148, United States
Paradigm Clinical Research - Boise, ID
NOT_YET_RECRUITING

Boise, Idaho, 83709, United States
Physicians East
RECRUITING

Greenville, North Carolina, 27834, United States
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Radiance Clinical Research
RECRUITING

Lampasas, Texas, 76550, United States
Remington Davis, Inc
RECRUITING

Columbus, Ohio, 43215, United States
St. Elizabeth Healthcare
RECRUITING

Edgewood, Kentucky, 41017, United States
Suburban Research Associates
RECRUITING

West Chester, Pennsylvania, 19380, United States
Suncoast Clinical Research, Inc
NOT_YET_RECRUITING

New Port Richey, Florida, 34652, United States
Texas Diabetes & Endocrinology, P.A. - Round Rock
RECRUITING

Round Rock, Texas, 78681, United States
Texas Valley Clinical Research - Mission, TX
NOT_YET_RECRUITING

Mission, Texas, 78572, United States
Texas Valley Clinical Research - San Antonio TX
NOT_YET_RECRUITING

San Antonio, Texas, 78251, United States
Texas Valley Clinical Research, LLC
RECRUITING

Weslaco, Texas, 78596, United States
The Center for Diabetes and Endocrine Care
RECRUITING

Fort Lauderdale, Florida, 33312, United States
Tulane University School of Medicine
RECRUITING

New Orleans, Louisiana, 70112, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
Velocity Clinical Research - Cincinnati, Blue Ash
RECRUITING

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research - Dallas
RECRUITING

Dallas, Texas, 75230, United States
Velocity Clinical Research - Gardena
RECRUITING

La Mesa, California, 91942, United States
Velocity Clinical Research, Anderson
RECRUITING

Anderson, South Carolina, 29621, United States
Velocity Clinical Research, Austin
RECRUITING

Austin, Texas, 78759, United States
Velocity Clinical Research, Cincinnati, Mt. Auburn
RECRUITING

Cincinnati, Ohio, 45219, United States
Velocity Clinical Research, Huntington Park
RECRUITING

Huntington Park, California, 90255, United States
Velocity Clinical Research, Lafayette
RECRUITING

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research, Lincoln
RECRUITING

Lincoln, Nebraska, 68510, United States
Velocity Clinical Research, Los Angeles
RECRUITING

Los Angeles, California, 90057, United States
Velocity Clinical Research, New Smyrna Beach
RECRUITING

Edgewater, Florida, 32132, United States
Velocity Clinical Research, Omaha
RECRUITING

Omaha, Nebraska, 68134, United States
Velocity Clinical Research, Rockville
RECRUITING

Rockville, Maryland, 20854, United States
Velocity Clinical Research, Salt Lake City
RECRUITING

West Jordan, Utah, 84088, United States
Velocity Clinical Research, Sioux City
RECRUITING

Sioux City, Iowa, 51106, United States
Velocity Clinical Research, Suffolk
RECRUITING

Suffolk, Virginia, 23435, United States
Willamette Valley Clinical Studies
NOT_YET_RECRUITING

Eugene, Oregon, 97404, United States

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