New drug aims to tackle diabetes by targeting stress hormone

NCT ID NCT07296484

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol levels to see if the drug helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

clofutriben (a drug that blocks an enzyme involved in cortisol production)

What this could lead to

If it works, this could lead to a new treatment option for people with type 2 diabetes who also have high cortisol levels.

What could go wrong

This is a phase 2 trial, so it's still early. The drug may not improve blood sugar control better than placebo, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Cushing syndrome ectopic ACTH secretion syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Accellacare Charleston

    NOT_YET_RECRUITING

    Mt. Pleasant, South Carolina, 29464, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Admed Research LLC

    RECRUITING

    Miami, Florida, 33173, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Albany Medical College

    NOT_YET_RECRUITING

    Albany, New York, 12203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Alliance Clinical - Las Vegas

    NOT_YET_RECRUITING

    Las Vegas, Nevada, 89108, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Alliance Clinical - Lewisville (Epic Clinical Research)

    NOT_YET_RECRUITING

    Lewisville, Texas, 75057, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Alliance Clinical San Diego

    NOT_YET_RECRUITING

    San Diego, California, 92120, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Amicis Research Center- Nordhoff

    RECRUITING

    Northridge, California, 98433, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Arizona Clinical Trials - Broadway

    RECRUITING

    Tucson, Arizona, 85711, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Arizona Clinical Trials - Pecos

    RECRUITING

    Chandler, Arizona, 85225, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ark Clinical Research - Fountain Valley

    RECRUITING

    Fountain Valley, California, 92708, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ark Clinical Research - Long Beach

    RECRUITING

    Long Beach, California, 90815, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Chicago Clinical Research Institute

    RECRUITING

    Chicago, Illinois, 60607, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Diabetes & Glandular Disease Clinic, P.A.

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Elevate Clinical Research

    RECRUITING

    Seabrook, Texas, 77586, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Elixia SISU BHR - Springfield

    RECRUITING

    Springfield, Massachusetts, 011030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Emory University School of Medicine

    RECRUITING

    Atlanta, Georgia, 30303, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Endocrine Associates of Long Island, P.C.

    RECRUITING

    Smithtown, New York, 11787, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Endocrinology Associates, Inc

    RECRUITING

    Columbus, Ohio, 43201, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • IACT Health-Brookstone Centre Pkwy

    RECRUITING

    Columbus, Georgia, 31904, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Innovative Research Institute

    NOT_YET_RECRUITING

    Port Charlotte, Florida, 33952, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Iowa Diabetes and Endocrinology Research Center

    RECRUITING

    West Des Moines, Iowa, 50226, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Juno Research, LLC

    RECRUITING

    Houston, Texas, 77040, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Los Angeles Institute for Metabolic Research

    RECRUITING

    Los Angeles, California, 90015, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lucas Research Inc

    RECRUITING

    Morehead City, North Carolina, 28557, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NOLA Care Clinical Research

    RECRUITING

    Metairie, Louisiana, 70006, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Oakland Medical Research Center

    RECRUITING

    Troy, Michigan, 48085, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • PMG Research of Wilmington, LLC

    NOT_YET_RECRUITING

    Wilmington, North Carolina, 28401, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Palm Research Center, Inc.

    RECRUITING

    Las Vegas, Nevada, 89148, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Paradigm Clinical Research - Boise, ID

    NOT_YET_RECRUITING

    Boise, Idaho, 83709, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Physicians East

    RECRUITING

    Greenville, North Carolina, 27834, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Progressive Medical Research

    RECRUITING

    Port Orange, Florida, 32127, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Radiance Clinical Research

    RECRUITING

    Lampasas, Texas, 76550, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Remington Davis, Inc

    RECRUITING

    Columbus, Ohio, 43215, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • St. Elizabeth Healthcare

    RECRUITING

    Edgewood, Kentucky, 41017, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Suburban Research Associates

    RECRUITING

    West Chester, Pennsylvania, 19380, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Suncoast Clinical Research, Inc

    NOT_YET_RECRUITING

    New Port Richey, Florida, 34652, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Diabetes & Endocrinology, P.A. - Round Rock

    RECRUITING

    Round Rock, Texas, 78681, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Valley Clinical Research - Mission, TX

    NOT_YET_RECRUITING

    Mission, Texas, 78572, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Valley Clinical Research - San Antonio TX

    NOT_YET_RECRUITING

    San Antonio, Texas, 78251, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Valley Clinical Research, LLC

    RECRUITING

    Weslaco, Texas, 78596, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Center for Diabetes and Endocrine Care

    RECRUITING

    Fort Lauderdale, Florida, 33312, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Tulane University School of Medicine

    RECRUITING

    New Orleans, Louisiana, 70112, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research - Cincinnati, Blue Ash

    RECRUITING

    Cincinnati, Ohio, 45242, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research - Dallas

    RECRUITING

    Dallas, Texas, 75230, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research - Gardena

    RECRUITING

    La Mesa, California, 91942, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Anderson

    RECRUITING

    Anderson, South Carolina, 29621, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Austin

    RECRUITING

    Austin, Texas, 78759, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Cincinnati, Mt. Auburn

    RECRUITING

    Cincinnati, Ohio, 45219, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Huntington Park

    RECRUITING

    Huntington Park, California, 90255, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Lafayette

    RECRUITING

    Lafayette, Louisiana, 70508, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Lincoln

    RECRUITING

    Lincoln, Nebraska, 68510, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Los Angeles

    RECRUITING

    Los Angeles, California, 90057, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, New Smyrna Beach

    RECRUITING

    Edgewater, Florida, 32132, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Omaha

    RECRUITING

    Omaha, Nebraska, 68134, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Rockville

    RECRUITING

    Rockville, Maryland, 20854, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Salt Lake City

    RECRUITING

    West Jordan, Utah, 84088, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Sioux City

    RECRUITING

    Sioux City, Iowa, 51106, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Velocity Clinical Research, Suffolk

    RECRUITING

    Suffolk, Virginia, 23435, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Willamette Valley Clinical Studies

    NOT_YET_RECRUITING

    Eugene, Oregon, 97404, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••