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Can a single surgery fix ankle cartilage for a decade? a long-term study puts AMIC to the test.

NCT ID NCT07725770

Disease control Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This study looks at how well a surgical technique called AMIC holds up ten years after repairing cartilage damage in the ankle. Researchers are checking whether the pain relief and function patients gained in the first few years remain stable or fade over time. About 40 people who had the procedure between 2013 and 2016 are being followed up to see if the benefits last.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
autologous matrix-induced chondrogenesis (AMIC) using a porcine collagen I/III membrane
What this could lead to
If successful, this could confirm that the AMIC procedure provides lasting relief for ankle cartilage defects, reducing the need for more invasive surgeries.
What could go wrong
This is a small, single-center study with only 40 patients, and long-term outcomes may vary. The procedure involves surgery and recovery risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Jul 2026

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients treated for OLT between April 2013 and April 2016 at the IRCCS Ospedale Galeazzi Sant'Ambrogio.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Patients who underwent repair of an osteochondral defect via the AMIC® procedure utilizing a porcine collagen I/III membrane (Chondro-Gide®). Exclusion Criteria: \- Irrelevant post-operative diagnoses (e.g., pigmented villonodular synovitis) or the inability to retrieve follow-up data.

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Conditions

The condition(s) this trial relates to.

osteochondritis dissecans

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteochondral defect of talus

Contacts and locations

Locations

  • IRCCS Ospedale Galeazzi-Sant'Ambrogio

    Milan, Italy