Epigenetic drugs aim to stop cancer return after transplant in kids

NCT ID NCT03843528

Ongoing Disease control Sponsor: Johns Hopkins All Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial tests whether adding two drugs—vorinostat and low-dose azacitidine—after a stem cell transplant can help prevent relapse in children with certain myeloid cancers. The study includes children aged 1 to 21 with acute myeloid leukemia or related conditions. Researchers are looking for the safest dose of vorinostat when used with azacitidine, while also tracking side effects, graft-versus-host disease, and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vorinostat and low-dose azacitidine
What this could lead to: If it works, this combination could help prevent cancer relapse in children after a stem cell transplant, improving survival.
What could go wrong: This is an early, small dose-finding study, so safety and effectiveness are not yet known. Side effects from the drugs may limit their use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute myeloid leukemia juvenile myelomonocytic leukemia mixed phenotype acute leukemia myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA JUVENILE MYELOMONOCYTIC LEUKEMIA MIXED PHENOTYPE ACUTE LEUKEMIA MYELODYSPLASTIC SYNDROMES

Contacts and locations

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Locations

Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States

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