Dried plums may strengt hen bones in older women

NCT ID NCT02822378

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Recruiting now
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
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The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

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Approved
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First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests whether eating dried plums (prunes) every day for a year can improve bone density and strength in postmenopausal women with low bone mass. Participants eat either 6 or 12 dried plums daily, plus calcium and vitamin D supplements. Researchers measure changes in bone density and look for clues in urine and blood about how dried plums might work.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dried plums (prunes)
What this could lead to
If effective, eating dried plums could become a simple, non-drug way to help protect bone health in postmenopausal women.
What could go wrong
This is a dietary supplement study, not a drug trial, so effects may be modest. Results depend on women sticking to the daily regimen, and benefits may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

322 people

The number who actually took part.

Started

Jun 2016

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Postmenopausal women * not severely obese (BMI \< 40 kg/m2); * healthy (determined by a screening questionnaire, complete metabolic panel); * willing to include dried plums in their daily diet; * not taking any natural dietary supplement containing phenolics, blueberries or apples for at least 2 months prior to study entry; can stop for 2 months to meet entry criteria * non-smoking; ambulatory; * low BMD as measured by dual energy X-ray absorptiometry (DXA). Eligible BMD values (T-scores) for DXA measures of the lumbar spine, total hip and/or femoral neck will correspond to T-scores between 0 and -3.0. Exclusion Criteria: * Women who regularly consume dried plums, dried apples, prune juice, or heavy consumers of blueberries (1 cup or more/day). Potential volunteers who will refrain from consumption of the afore mentioned foods for the duration of the study will become eligible after a 2 month washout period; * vitamin D deficiency (\<20 ng/mL); * history of vertebral fracture or fragility fracture of the wrist, humerus, hip or pelvis after age 50 yr); * untreated hyper- or hypothyroidism; * current hyper- or hypoparathyroidism; * significantly impaired renal function; high potassium * current hypo- or hypercalcemia; * history of spinal stenosis; * history of heart attack, stroke, thromboembolism, kidney disease, malabsorption syndrome, seizure disorders; * positive for HIV, Hep-C or Hep-B surface antigen and malignancy. * Use of the following agents affecting bone metabolism: * intravenous bisphosphonates at any time; * fluoride (for osteoporosis) within the past 24 months; * denosumab at any time; * bisphosphonates, parathyroid hormone or strontium within the past 12 months; * calcitonin or selective estrogen receptor modulators within the past 12 months; * systemic oral or transdermal estrogen within the past 3 months; * systemic glucocorticosteroids (≥ 5 mg prednisone equivalent per day for more than 10 days); or * tibolone within the past 3 months. * Participants who will not consume study therapy or will not stop taking natural product supplements of their own selection.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Women's Health and Exercise Laboratories, The Pennsylvania State University

    University Park, Pennsylvania, 16802, United States

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