Could adding a second drug boost bone strength in osteoporosis?
NCT ID NCT04467983
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with denosumab alone or add daily abaloparatide injections for 18 months. The main goal is to measure changes in bone density at the hip and spine.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Abaloparatide (Tymlos) added to Denosumab (Prolia)
- What this could lead to
- If successful, this could show that adding abaloparatide to ongoing denosumab treatment significantly improves bone density in postmenopausal women with osteoporosis, offering a stronger treatment option.
- What could go wrong
- This is a small, early-phase 4 trial with only 70 participants, so results may not apply to everyone. Adding a daily injection may also increase side effects or be hard for patients to stick with.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital for Special Surgery
New York, New York, 10021, United States
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