Can an enzyme shield the gut during transplant recovery?
NCT ID NCT04692181
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an oral enzyme called SYN-004 in adults who have received a stem cell transplant and need intravenous antibiotics for fever. The enzyme is designed to break down antibiotics in the gut, protecting the natural bacteria there. Researchers will check safety, whether the enzyme enters the blood, and if it helps prevent infections and improve outcomes. The trial involves 36 participants and is in early phases (1b/2a).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SYN-004 (Ribaxamase), an oral enzyme that breaks down certain antibiotics in the gut
- What this could lead to
- If it works, SYN-004 could help protect the gut microbiome during antibiotic treatment, potentially reducing infections and improving recovery in stem cell transplant patients.
- What could go wrong
- This is an early-phase trial with only 36 participants, so results may not apply broadly. The drug might not effectively protect the microbiome or could interfere with antibiotic levels in the blood.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE GRAFT-VERSUS-HOST REACTION FOLLOWING BONE MARROW TRANSPLANT are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can specially trained immune cells flush out hidden HIV?
- Frailty check may steer safer cancer care for seniors
- Could gratitude exercises aid blood cancer recovery?
- Can a new tracer light up cancer growth?
- Could a walk a day keep brain fog away after a stem cell transplant?
- Could End-of-Life care for blood cancer patients be done at home?