New drug combo targets Hard-to-Treat cancers in early trial

NCT ID NCT04670679

Ongoing Disease control Sponsor: Erasca, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take part across multiple centers.

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Conditions

The condition(s) this trial relates to.

chordoma colorectal neoplasm metastatic malignant neoplasm neoplasm Neoplasm Metastasis Noonan syndrome Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC SOLID TUMORS

Contacts and locations

Locations

Comprehensive Cancer Centers of Nevada

Henderson, Nevada, 89014, United States
Linear Clinical Research

Perth, Western Australia, Australia
Mary Crowley Cancer Research

Dallas, Texas, 75251, United States
Massachusetts General Hospital

Boston, Massachusetts, 02215, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia
Sarah Cannon Research Institute (Florida Cancer Specialists)

Sarasota, Florida, 34232, United States
Sarah Cannon Research Institute (Tennessee Oncology)

Nashville, Tennessee, 37203, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Washington University

St Louis, Missouri, 63110, United States

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