ADVANCED OR METASTATIC SOLID TUMORS

This early-stage study is testing a new drug called PRTH-101, both alone and combined with an existing immunotherapy (pembrolizumab), in adults with advanced or metastatic solid tumors. The main goals are to find a safe dose, see how the body processes the drug, and check for ear…

This early-stage study is testing a new drug called IDE161, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors that have spread. The main goals are to find safe doses and see if the treatment shows early signs of shrinkin…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This is the first study in people to test a new immunotherapy drug called PMC-309. It aims to see if the drug is safe and how the body processes it when given alone or with another cancer drug, pembrolizumab. The study is for adults with advanced solid tumors that have spread or …

This is the first human study of LNCB74, a new targeted cancer drug designed to deliver chemotherapy directly to cancer cells. Researchers will test different doses in 145 adults with advanced solid tumors (including ovarian, breast, lung, and other cancers) to find the safest an…

This is the first study in humans testing a new drug called IPH4502 for patients with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and look for early signs that the drug might help control …

This study is testing a new drug called TAK-188 in adults with advanced solid tumors that have not gotten better with standard treatments. TAK-188 is designed to help the body's own immune system fight cancer by targeting specific cells inside tumors that weaken the immune respon…

This is a first-in-human study to check the safety and find the right dose of a new drug, KGX101, given alone or with another cancer drug called envafolimab. It involves about 57 Chinese patients with advanced solid tumors that have not responded to standard treatments. The main …

This is the first human study of a new cancer drug called HM16390, testing it both alone and combined with an existing immunotherapy (pembrolizumab). The trial aims to find safe doses and see if the treatment helps patients with advanced solid tumors that have stopped responding …

This is the first human study of a new cancer drug called BH3120. Researchers are testing it alone and combined with an existing immunotherapy (pembrolizumab) in 245 patients with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find s…

This is the first study in people testing a new experimental drug called DAY301 for advanced cancers that have spread. Researchers will give increasing doses to about 254 patients with specific advanced solid tumors to find the safest dose and see if the drug shows early signs of…

This is the first time researchers are testing the experimental drug KK2260 in people. The study aims to find a safe dose for patients with advanced solid tumors that have spread. Later parts will test if the drug can help control specific cancers of the esophagus, head, and neck…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…