New smart drug targets cancer cells in early trial

NCT ID NCT05948865

Recruiting now Disease control Sponsor: Conjupro Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests CPO301, a drug designed to seek out and attack cancer cells that have a protein called EGFR on their surface. About 132 adults with advanced solid tumors (including lung, breast, and head & neck cancers) will receive the drug by IV every three weeks. The main goals are to check safety, find the best dose, and see early signs of tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CPO301 (also known as SYS6010), an antibody-drug conjugate that targets EGFR on cancer cells
What this could lead to: If successful, this could lead to a new treatment option for advanced solid tumors like lung cancer that have not responded to other therapies.
What could go wrong: This is an early Phase 1 trial with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer cancer colorectal cancer head and neck cancer lung cancer lung carcinoma lung neoplasm metastatic malignant neoplasm neoplasm Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CANCER, LUNG

Contacts and locations

Locations

AdventHealth Cancer Institute
RECRUITING

Celebration, Florida, 34747, United States
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92658, United States
Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
NEXT Dallas
RECRUITING

Dallas, Texas, 75039, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Princess Margaret Cancer Centre - University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute (SCRI) at HealthONE
RECRUITING

Denver, Colorado, 80218, United States
UCLA Hematology/Oncology - Santa Monica
RECRUITING

Santa Monica, California, 90404, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.