New drug TAK-188 aims to unleash immune system against Hard-to-Treat tumors

NCT ID NCT07205718

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study tests a new medicine called TAK-188 in adults with advanced solid tumors that have not improved with standard treatments. TAK-188 targets and removes certain cells inside tumors that weaken the immune system, potentially allowing the body to better fight the cancer. The trial will check safety, tolerability, and how well the drug works over up to one year of treatment, with follow-up for another year.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC SOLID TUMORS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Florida Cancer Specialists - Lake Nona
RECRUITING

Orlando, Florida, 32827, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111-2497, United States
Johns Hopkins
RECRUITING

Baltimore, Maryland, 21231, United States

Contact Email: •••••@•••••
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4000, United States
NEXT Dallas
RECRUITING

Irving, Texas, 75039, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Providence Cancer Institute, Franz Clinic
RECRUITING

Portland, Oregon, 97213-2933, United States
SCRI Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
UCLA Health-Santa Monica Cancer Care (Cancer Care - Santa Monica)
RECRUITING

Santa Monica, California, 90404, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106-1716, United States
Washington University
RECRUITING

St Louis, Missouri, 63108, United States
Yale School of Medicine - Smilow Cancer Hospital - Center for Thoracic Cancers
RECRUITING

New Haven, Connecticut, 06511, United States

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