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Can a new pill ease arthritis in kids?

NCT ID NCT03725007

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study is testing an oral medication called upadacitinib in children with polyarticular juvenile idiopathic arthritis (JIA), a condition causing joint inflammation. The goal is to understand how the drug moves through the body, its safety, and how well children tolerate it. Participants receive the drug in multiple parts, including a long-term extension to monitor ongoing safety and effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
upadacitinib (an oral drug that modulates the immune system)
What this could lead to
If successful, this could provide a new treatment option to help control arthritis symptoms and improve quality of life for children with this condition.
What could go wrong
This is an early-phase study, so the drug may not work as hoped or could cause side effects. Results from this small group may not apply to all children with JIA.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

juvenile idiopathic arthritis polyarticular juvenile idiopathic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

JUVENILE IDIOPATHIC ARTHRITIS (JIA)

Contacts and locations

Locations

  • Aichi Children's Health and Medical Center /ID# 248327

    Obu-shi, Aichi-ken, 474-8710, Japan

  • Alberta Children's Hospital /ID# 251738

    Calgary, Alberta, T3B 6A8, Canada

  • Ann & Robert H. Lurie Children's Hospital of Chicago /ID# 211162

    Chicago, Illinois, 60611, United States

  • Asklepios Klinik Sankt Augustin /ID# 203264

    Sankt Augustin, North Rhine-Westphalia, 53757, Germany

  • Boston Children's Hospital /ID# 202993

    Boston, Massachusetts, 02115, United States

  • British Columbia Children and Women's Hospital and Health Centre /ID# 251736

    Vancouver, British Columbia, V6H 3N1, Canada

  • Centro de Reumatologia Pediatrico de Puerto Rico /Id# 204406

    Bayamón, 00959, Puerto Rico

  • Children's Hospital of Pittsburgh of UPMC /ID# 202994

    Pittsburgh, Pennsylvania, 15224-1334, United States

  • Cincinnati Childrens Hospital Medical Center /ID# 209697

    Cincinnati, Ohio, 45229, United States

  • Duplicate_McGill University Health Centre /ID# 251252

    Montreal, Quebec, H4A 3J1, Canada

  • Duplicate_University of Louisville /ID# 202896

    Louisville, Kentucky, 40202, United States

  • GCM Medical Group /ID# 211702

    San Juan, 00917-3104, Puerto Rico

  • Hamburger Zentrum fuer Kinder- und Jugendrheumatologie /ID# 206571

    Hamburg, 22081, Germany

  • Helios Klinikum Berlin-Buch /ID# 206859

    Berlin, 13125, Germany

  • Hospital Infantil Universitario Nino Jesus /ID# 206466

    Madrid, 28009, Spain

  • Hospital Sant Joan de Deu /ID# 203915

    Esplugues de Llobregat, Barcelona, 08950, Spain

  • Hospital Universitario La Paz /ID# 203927

    Madrid, 28046, Spain

  • Hospital Universitario Ramon y Cajal /ID# 203917

    Madrid, 28034, Spain

  • Hospital Universitario y Politecnico La Fe /ID# 203914

    Valencia, 46026, Spain

  • Hyogo Prefectural Kobe Children'S Hospital - Minatojima /ID# 246582

    Kobe, Hyōgo, 650-0045, Japan

  • Institute of Science Tokyo Hospital /ID# 246500

    Bunkyo-ku, Tokyo, 113-8519, Japan

  • Kagoshima University Hospital /ID# 246501

    Kagoshima, Kagoshima-ken, 890-8520, Japan

  • Mindful Medical Research /ID# 204488

    San Juan, 00918-3756, Puerto Rico

  • Miyagi Children's Hospital /ID# 246734

    Sendai, Miyagi, 989-3126, Japan

  • Niigata University Medical and Dental Hospital /ID# 247246

    Niigata, Niigata, 951-8520, Japan

  • Ospedale Pediatrico Bambino Gesù /ID# 203835

    Rome, Roma, 00165, Italy

  • PRI - Pediatric Rheumatology Research Institute /ID# 205954

    Bad Bramstedt, Schleswig-Holstein, 24576, Germany

  • Queen Silvia Children's Hosp /ID# 251145

    Gothenburg, Västra Götaland County, 416 85, Sweden

  • Randall Children's Hospital /ID# 213609

    Portland, Oregon, 97227-1654, United States

  • Seattle Children's Hospital /ID# 203003

    Seattle, Washington, 98105, United States

  • Semmelweis Egyetem /ID# 208970

    Budapest, 1085, Hungary

  • St Marianna University School Of Medicine /ID# 246478

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • St. Josef-Stift Sendenhorst /ID# 244740

    Sendenhorst, North Rhine-Westphalia, 48324, Germany

  • The Chaim Sheba Medical Center /ID# 222370

    Ramat Gan, Tel Aviv, 5265601, Israel

  • The Children's Hospital of Philadelphia /ID# 209617

    Philadelphia, Pennsylvania, 19104, United States

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