Polyarticular juvenile idiopathic arthritis

This study is testing the long-term safety and effectiveness of the drug filgotinib in children and adolescents aged 8 to 17 with juvenile idiopathic arthritis. Participants must have already completed a previous filgotinib study and shown improvement. The goal is to see if the d…

This study looks at the safety and effectiveness of the drug Xeljanz in children aged 2 to 17 with active juvenile idiopathic arthritis or juvenile psoriatic arthritis. It is an observational study in Korean clinics, meaning doctors prescribe the drug as usual and researchers mon…

This study is for children aged 2 to 17 with polyarticular juvenile idiopathic arthritis (JIA) whose first TNF inhibitor medication did not work well enough. It compares three different non-TNFi drugs (abatacept, tocilizumab, tofacitinib) against a second TNF inhibitor to see whi…

This study tests a daily pill called filgotinib in children aged 8 to 17 with a type of arthritis that affects multiple joints. The goal is to see if the drug is safe and helps control the disease over 18 weeks. About 65 participants will take the drug and be monitored for side e…

This early-phase trial is testing a new treatment called KN5601, which uses a patient's own immune cells (NK cells) that have been engineered to target and destroy harmful B cells. The goal is to see if it is safe and can help children aged 5 and older with rheumatic diseases lik…

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This early-stage trial tests a new type of CAR-T cell therapy in 11 children with severe rheumatic diseases like juvenile dermatomyositis and arthritis that haven't improved with standard treatments. The therapy uses specially engineered immune cells to target and calm the overac…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests whether eating freeze-dried wild blueberry powder every day for 12 weeks can improve gut health, reduce inflammation, and ease joint pain in adults with arthritis. Fifty participants will take either the blueberry powder or a placebo, with a 2-week break between …

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study is creating a large collection of joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new biomarkers that could help diagnose arthritis earlier and monitor how the disease changes over time or with…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…