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Could a Blood-Derived injection ease jaw pain without surgery?

NCT ID NCT05214924

Disease control Sponsor: Wroclaw Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial tests whether injections of platelet-rich fibrin (iPRF), made from a patient's own blood, can reduce pain and improve jaw function in people with mild to moderate temporomandibular joint (TMJ) degeneration. Forty-two adults with TMJ arthritis or osteoarthritis will receive either iPRF or standard platelet-rich plasma (PRP) injections over 30 days. Researchers will track changes in pain, jaw mobility, and joint health using exams and imaging for up to 120 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (iPRF)
What this could lead to
If effective, iPRF injections could offer a non-surgical way to reduce pain and improve jaw function in people with TMJ degeneration.
What could go wrong
This is a small, early-phase trial with only 42 participants. The treatment may not work better than the standard PRP injections, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age between 18 and 80 years old * mild to moderate degenerative temporomandibular joint disease based on DC/TMD protocol and MRI/CT * agreement to take part in the study Exclusion Criteria: * severe hematologic and/or neurological disorder * rheumatoid arthritis * septic arthritis * polymyalgia rheumatica * gout * Paget's disease * osteonecrosis * connective tissue disease * malignant disease * vasculitis * any previous temporomandibular joint (TMJ) invasive treatment * any current temporomandibular joint (TMJ) conservative or invasive treatment * patients who had used oral, parenteral or intra-articular corticosteroids in the 3 months prior to the first injection * previous or current radiotherapy of head and neck * pregnancy or lactation * presence of severe mental disorders * drug and/or alcohol addiction * presence of local contraindications for injection therapy * patients with needle phobia * presence of hypersensitivity to substances to be used in the study

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular arthritis Temporomandibular disorder Temporomandibular joint disorders Temporomandibular joint osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Wroclaw Medical University

    Wroclaw, Poland

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