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Could a Blood-Derived injection ease jaw pain without surgery?

NCT ID NCT05214924

ENROLLING_BY_INVITATION Disease control Sponsor: Wroclaw Medical University Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial tests whether injections of platelet-rich fibrin (iPRF), made from a patient's own blood, can reduce pain and improve jaw function in people with mild to moderate temporomandibular joint (TMJ) degeneration. Forty-two adults with TMJ arthritis or osteoarthritis will receive either iPRF or standard platelet-rich plasma (PRP) injections over 30 days. Researchers will track changes in pain, jaw mobility, and joint health using exams and imaging for up to 120 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (iPRF)
What this could lead to
If effective, iPRF injections could offer a non-surgical way to reduce pain and improve jaw function in people with TMJ degeneration.
What could go wrong
This is a small, early-phase trial with only 42 participants. The treatment may not work better than the standard PRP injections, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TEMPOROMANDIBULAR ARTHRITIS TEMPOROMANDIBULAR DISORDER TEMPOROMANDIBULAR JOINT DISORDERS TEMPOROMANDIBULAR JOINT OSTEOARTHRITIS

Contacts and locations

Locations

  • Wroclaw Medical University

    Wroclaw, Poland

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