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Blood-Derived injection may ease jaw pain better than steroids

NCT ID NCT07691684

Completed Symptom relief Sponsor: University Of Anbar Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tested whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can reduce pain and clicking in the jaw joint (TMJ) and improve mouth opening. Thirty adults with a slipped jaw disc were randomly assigned to receive PRP, a steroid with anesthetic, or a saltwater placebo. After one week, both PRP and the steroid reduced pain and clicking more than placebo, and PRP also improved how wide patients could open their mouth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Platelet-Rich Plasma (PRP) and Dexamethasone with Local Anaesthetic
What this could lead to
If PRP proves effective, it could offer a longer-lasting, natural treatment for TMJ disorders without the side effects of steroids.
What could go wrong
This is a small, early-stage trial with only 30 participants and short follow-up. Results may not apply to all TMJ patients, and PRP's benefits over time are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TEMPOROMANDIBULAR JOINT DISORDERS TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME TEMPOROMANDIBULAR JOINT INTERNAL DERANGEMENT

Contacts and locations

Locations

  • College of Dentistry, University of Anbar

    Ramadi, Al Najaf, 54001, Iraq

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