Cure My Disease

Don't miss your cure!

 Log in / Sign up

Blood-Derived injection may ease jaw pain better than steroids

NCT ID NCT07691684

Symptom relief Sponsor: University Of Anbar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tested whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can reduce pain and clicking in the jaw joint (TMJ) and improve mouth opening. Thirty adults with a slipped jaw disc were randomly assigned to receive PRP, a steroid with anesthetic, or a saltwater placebo. After one week, both PRP and the steroid reduced pain and clicking more than placebo, and PRP also improved how wide patients could open their mouth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-Rich Plasma (PRP) and Dexamethasone with Local Anaesthetic
What this could lead to
If PRP proves effective, it could offer a longer-lasting, natural treatment for TMJ disorders without the side effects of steroids.
What could go wrong
This is a small, early-stage trial with only 30 participants and short follow-up. Results may not apply to all TMJ patients, and PRP's benefits over time are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Dec 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inclusion Criteria: * Skeletally mature patients aged 18 years or older * Symptomatic TMJ internal derangement in the form of disc displacement with reduction (DDwR), diagnosed using DC/TMD Axis I clinical criteria * TMJ arthralgia confirmed by pain reproduced on palpation or provoked by jaw movement * Clicking sound detectable on palpation or auscultation during opening and closing movements * Elimination or marked reduction of the click on mouth opening from a protruded position Exclusion Criteria: * Intra-articular injection within the previous six months * Systemic inflammatory arthropathy * Coagulopathy * Active local infection * Low platelet count * Ongoing antiplatelet or anticoagulant therapy * Pregnancy

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Temporomandibular joint disorders are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular joint disorders Temporomandibular joint dysfunction syndrome Temporomandibular joint internal derangement

Contacts and locations

Locations

  • College of Dentistry, University of Anbar

    Ramadi, Al Najaf, 54001, Iraq

More trials for these conditions

Other studies related to the condition(s) this trial covers.