Can a single injection ease jaw joint pain?

NCT ID NCT07750483

Completed Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests three different injection combinations for people with a painful jaw joint condition called TMJ internal derangement. Participants receive one injection of hyaluronic acid mixed with either platelet-rich plasma, tenoxicam, or a corticosteroid. The study measures pain, jaw opening, clicking sounds, and MRI changes over six months to see which combination works best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intra-articular injections of hyaluronic acid combined with either platelet-rich plasma, tenoxicam, or corticosteroid
What this could lead to: If successful, this could identify a more effective injection therapy for TMJ disorders, potentially reducing pain and improving jaw function without surgery.
What could go wrong: This is a small, early-stage trial, and results may not apply to all patients. Injections carry risks like infection or pain, and the effects may be temporary.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TEMPOROMANDIBULAR JOINT INTERNAL DERANGEMENT

Contacts and locations

Locations

Faculty of Dentistry, Mansoura University

Al Mansurah, Dakahlia Governorate, Egypt

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