Jaw pain relief? PRP and hyaluronic acid injections show promise in small study

NCT ID NCT07643402

Completed Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure changes in movement, pain, and how wide they could open their mouth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Platelet-rich plasma (PRP) and hyaluronic acid
What this could lead to: If it works, this could offer a non-surgical option to reduce jaw pain and improve mouth opening for people with jaw joint problems.
What could go wrong: This was a small, completed study with only 22 people and no control group. Results may not apply to everyone, and injections can cause temporary soreness or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fatal familial insomnia temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DISC DISPLACEMENT WITH REDUCTION TEMPOROMANDIBULAR JOINT DISC DISPLACEMENT, WITH REDUCTION

Contacts and locations

Locations

Faculty of Dentistry, Mansoura university

Al Mansurah, Dakahlia Governorate, 35516, Egypt

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