Could a simple supplement shield bones and kidneys from common heartburn drugs?
NCT ID NCT05998863
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants must be over 21, have taken PPIs for at least two months, and have controlled blood pressure or type 2 diabetes. The study compares the supplement to a placebo over one year, measuring changes in bone density, magnesium levels, and kidney function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Effervescent calcium magnesium citrate
What this could lead to
If it works, this supplement could help prevent osteoporosis, magnesium deficiency, and kidney problems in people who need long-term acid-reducing medication.
What could go wrong
This is a Phase 3 trial, but it is still testing whether the supplement works for these purposes. Results may not apply to everyone, and the supplement may cause side effects like digestive upset.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390-9107, United States