Could a simple supplement shield bones and kidneys from common heartburn drugs?

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants must be over 21, have taken PPIs for at least two months, and have controlled blood pressure or type 2 diabetes. The study compares the supplement to a placebo over one year, measuring changes in bone density, magnesium levels, and kidney function.