Childhood leukaemia trial seeks best chemo cocktail
NCT ID NCT02724163
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This trial investigates the best way to treat children with acute myeloid leukaemia (AML) by comparing different chemotherapy drugs and doses. It tests whether adding up to three doses of the targeted drug gemtuzumab ozogamicin to standard chemo is safe and effective. The study also compares two types of chemotherapy for induction and two different conditioning regimens for stem cell transplants. Around 700 children under 18 with AML or related conditions are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Gemtuzumab ozogamicin (Mylotarg), liposomal daunorubicin, mitoxantrone, cytarabine, fludarabine, busulfan, cyclophosphamide
What this could lead to
If successful, this could identify safer, more effective chemotherapy and antibody-drug combinations for children with AML, potentially improving survival and reducing side effects.
What could go wrong
This is a large phase 3 trial, but some drug combinations were dropped early due to manufacturing issues. Results may not apply to all AML subtypes, and side effects from intensive chemo remain significant.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aberdeen Royal Infirmary, NHS Grampian
Aberdeen, AB25 2ZN, United Kingdom
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Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge, CB2 0QQ, United Kingdom
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Alder Hey Children's NHS Foundation Trust
Liverpool, L12 2AP, United Kingdom
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Birmingham Children's Hospital NHS Foundation Trust
Birmingham, B4 6NH, United Kingdom
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Cardiff and Vale University Health Board, Noah's Ark Children's Hospital for Wales
Cardiff, CF14 4XW, United Kingdom
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Centre Hospitalier Regional Universitaire Besancon - Hopital Jean Minjoz
Besançon, France
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Centre Hospitalier Regional Universitaire Brest - Hopital Morvan
Brest, France
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Centre Hospitalier Regional Universitaire De Tours - Hopital Clocheville
Tours, France
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Centre Hospitalier Regional Universitaire Montpellier - Hopital Arnaud-de-villeneuve
Montpellier, France
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Centre Hospitalier Universitaire Amiens - Picardie
Amiens, France
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Centre Hospitalier Universitaire D'angers
Angers, France
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Centre Hospitalier Universitaire De Bordeaux - Hopital Pellegrin
Bordeaux, France
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Centre Hospitalier Universitaire De Caen
Caen, France
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Centre Hospitalier Universitaire De Clermont-ferrand
Clermont-Ferrand, France
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Centre Hospitalier Universitaire De Grenoble
Grenoble, France
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Centre Hospitalier Universitaire De Limoges
Limoges, France
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Centre Hospitalier Universitaire De NICE
Nice, France
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Centre Hospitalier Universitaire De Nancy
Nancy, France
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Centre Hospitalier Universitaire De Nantes
Nantes, France
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Centre Hospitalier Universitaire De Poitiers
Poitiers, France
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Centre Hospitalier Universitaire De Rennes - Hopital Sud
Rennes, France
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Centre Hospitalier Universitaire De Rouen
Rouen, France
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Centre Hospitalier Universitaire De Toulouse - Hopital Des Enfants
Toulouse, France
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Centre Hospitalier Universitaire Dijon Bourgogne - Hopital D'enfants
Dijon, France
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Centre Hospitalier Universitaire Saint-etienne
Saint-Etienne, France
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Centre Hospitalier Universitaire Vaudois Chuv Lausanne
Lausanne, Switzerland
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Centre Leon Berard
Lyon, France
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Christchurch Hospital
Christchurch, New Zealand
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Chu De Reims
Reims, France
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Great Ormond Street Hospital For Children NHS Trust
London, WC1N 3JH, United Kingdom
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Hopital Armand Trousseau
Paris, France
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Hopital De La Timone
Marseille, France
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Hopital Jeanne Dr Flandre
Lille, France
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Hopital Robert Debre
Paris, France
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Hopital Saint Louis
Paris, France
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Hug Hopitaux Universitaires De Geneve
Geneva, Switzerland
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Inselspital Bern
Bern, Switzerland
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John Hunter Children's Hopsital
New Lambton Heights, Australia
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John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust
Oxford, OX3 9DU, United Kingdom
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Kantonsspital Aarau
Aarau, Switzerland
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Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust
Leeds, LS9 7TF, United Kingdom
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Luzerner Kantonspital - Kinderspital Luzern
Lucerne, Switzerland
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Monash Children's Hospital
Melbourne, Australia
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NHS Greater Glasgow and Clyde, The Royal Hospital for Children
Glasgow, G51 4TF, United Kingdom
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NHS Lothian, Royal Hospital for Sick Children
Edinburgh, EH9 1LF, United Kingdom
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Nottingham University Hospitals NHS Trust
Nottingham, NG7 2UH, United Kingdom
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Ospedale San Giovanni
Bellinzona, Switzerland
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Ostschweizer Kinderspital
Sankt Gallen, Switzerland
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Our Lady's Hospital for Sick Children
Dublin, Ireland
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Perth Children's Hospital
Perth, Australia
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Queensland Children's Hospital
Brisbane, Australia
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Royal Aberdeen Children's Hospital
Aberdeen, AB25 2ZG, United Kingdom
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Royal Belfast Hospital for Sick Children
Belfast, County Antrim, BT12 6BE, United Kingdom
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Royal Childrens Hospital
Melbourne, Australia
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Royal Manchester Childrens' Hospital , Central Manchester University Hospitals NHS Foundation Trust
Manchester, M13 9WL, United Kingdom
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Sheffield Children's NHS Foundation Trust
Sheffield, S10 2TH, United Kingdom
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Southampton University Hospitals NHS Trust
Southampton, SO16 6YD, United Kingdom
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Starship Childrens Hospital
Auckland, New Zealand
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Strasbourg Hautepierre
Strasbourg, France
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Sydney Children's Hospital
Sydney, Australia
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The Childrens Hospital At Westmead
Westmead, Australia
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle, NE7 7DN, United Kingdom
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The Royal Marsden NHS Foundation Trust
London, SW3 6JJ, United Kingdom
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University Children's Hospital Zurich
Zurich, Switzerland
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University College London Hospitals NHS Foundation Trust
London, NW1 2PG, United Kingdom
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University Hospitals Bristol NHS Foundation Trust
Bristol, BS1 3NU, United Kingdom
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Universitäts-Kinderspital beider
Basel, Switzerland
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Women and Children's Hospital Adelaide
Adelaide, Australia