New combo therapy targets Hard-to-Cure leukemia in early trial

NCT ID NCT02879695

First seen May 16, 2026 ยท Last updated May 16, 2026

Summary

This early-stage study tests whether adding immune-boosting drugs (nivolumab and ipilimumab) to blinatumomab can help people with a severe form of B-cell leukemia that has returned or not responded to treatment. The main goals are to find safe doses and understand side effects. About 28 adults with relapsed or refractory B-ALL or mixed phenotype acute leukemia are participating.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary โ€” we know it does not capture everything.

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Contacts and locations

Locations

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.