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Triple-Target CAR T-Cells offer new hope for tough blood cancers

NCT ID NCT05418088

Recruiting now Disease control Sponsor: Sumithira Vasu Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new type of cell therapy for people with certain blood cancers (like lymphoma, leukemia) that have returned or stopped responding to standard treatments. The therapy uses a patient's own immune cells, which are genetically modified to recognize and attack cancer cells that carry three specific markers (CD19, CD20, CD22). The study aims to find the safest dose and check for side effects. About 54 adults will take part.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia B-cell chronic lymphocytic leukemia B-cell prolymphocytic leukemia Burkitt lymphoma childhood acute lymphoblastic leukemia high grade B-cell lymphoma indolent B-cell non-Hodgkin lymphoma non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT ACUTE LYMPHOBLASTIC LEUKEMIA RECURRENT B ACUTE LYMPHOBLASTIC LEUKEMIA RECURRENT B-CELL PROLYMPHOCYTIC LEUKEMIA RECURRENT CHRONIC LYMPHOCYTIC LEUKEMIA RECURRENT HIGH-GRADE B-CELL LYMPHOMA RECURRENT INDOLENT NON-HODGKIN LYMPHOMA RECURRENT NON-HODGKIN LYMPHOMA RECURRENT TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA REFACTORY CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA REFRACTORY B ACUTE LYMPHOBLASTIC LEUKEMIA REFRACTORY B-CELL PROLYMPHOCYTIC LEUKEMIA REFRACTORY CHILDHOOD NON-HODGKIN LYMPHOMA REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA REFRACTORY HIGH-GRADE B-CELL LYMPHOMA REFRACTORY INDOLENT NON-HODGKIN LYMPHOMA REFRACTORY NON-HODGKIN LYMPHOMA REFRACTORY TRANSFORMED CHRONIC LYMPHOCYTIC LEUKEMIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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