Scientists probe how a natural substance fuels leukemia

NCT ID NCT04460963

Ongoing Knowledge-focused Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examines how adrenomedullin, a natural protein, affects leukemia stem cells in patients with acute myeloid leukemia (AML). Researchers will collect bone marrow and blood samples from 72 newly diagnosed AML patients to measure adrenomedullin levels and study its effects on cell growth and movement. The goal is to understand if blocking adrenomedullin could stop leukemia cells from multiplying, but this is a lab-based study, not a treatment trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could point toward new ways to target leukemia stem cells by blocking adrenomedullin.
What could go wrong: This is an early, observational lab study with only 72 participants. It does not test a treatment in people, so any potential therapy is far off.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE MYELOID LEUKEMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

As Dell'Alto Adige, Ospedale Centrale Di Bolzano - Ematologia E Centro Trapianto Midollo Osseo

Bolzano, Italy
Ente Ecclesiastico Casa Sollievo Della Sofferenza - Ematologia

San Giovanni Rotondo, Italy
Policlinico S. Orsola-Malpighi - Uoc Ematologia

Bologna, Italy
U.O. Oncoematologia IOV

Castelfranco Veneto, Italy
Uo Ematologia - Azienda Ulss N.2 Marca Trevigiana

Treviso, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.