Could a platelet-boosting drug improve blood counts in certain blood cancers?
NCT ID NCT06630221
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether eltrombopag, a drug already approved for other blood disorders, can improve blood cell counts in people with low-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) who have a mutation in the TET2 gene. Participants take eltrombopag daily for up to 15 cycles. The study measures how well the drug restores healthy blood counts and tracks changes in the TET2 mutation over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
eltrombopag (Promacta)
What this could lead to
If it works, this could offer a new treatment option for people with low-risk MDS or CMML who have TET2 mutations, potentially improving blood counts and delaying disease progression.
What could go wrong
This is a small, early-phase trial with only 25 participants, so results may not apply to everyone. Eltrombopag is not yet approved for this use, and side effects or lack of response are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute
Cleveland, Ohio, 44195, United States