New combo treatment aims to save hips from collapse

NCT ID NCT05706909

Ongoing Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a procedure for people with early-stage osteonecrosis (bone death) of the hip. Doctors drill into the hip bone, inject a concentrated sample of the patient's own bone marrow, and add a special bone graft material called Genex. The goal is to see if this helps bone heal, prevents further collapse, and reduces pain. The trial involves 22 participants and is being run by the Cleveland Clinic.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Genex bone graft substitute with autologous bone marrow concentrate
What this could lead to: If successful, this could offer a way to repair bone damage and avoid hip replacement in people with early-stage osteonecrosis.
What could go wrong: This is a small, early study with only 22 participants, so results may not apply to everyone. The procedure involves surgery and there is no guarantee it will stop the disease from progressing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

avascular necrosis avascular necrosis of femoral head, primary, 1 osteonecrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AVASCULAR NECROSIS OSTEONECROSIS

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States

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