Can a drug free myelofibrosis patients from frequent blood transfusions?

NCT ID NCT04717414

Ongoing Disease control Sponsor: Celgene Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This phase 3 study tests whether the drug luspatercept can help people with myelofibrosis-related anemia become independent of red blood cell transfusions. Participants are adults with myelofibrosis who are already taking a JAK inhibitor and need regular transfusions. The study compares luspatercept to a placebo to see if it reduces or eliminates the need for transfusions over several weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a drug called luspatercept (ACE-536) given as a shot under the skin
What this could lead to: If it works, luspatercept could help people with myelofibrosis need fewer blood transfusions, improving their quality of life.
What could go wrong: This is a phase 3 trial, but the drug may not work better than placebo, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anemia myelofibrosis Myeloproliferative Disorders myeloproliferative neoplasm primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA MYELOFIBROSIS MYELOPROLIFERATIVE DISORDERS POST-POLYCYTHEMIA VERA MYELOFIBROSIS PRIMARY MYELOFIBROSIS

Contacts and locations

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Locations

A.O.U. Maggiore della Carit

Novara, 28100, Italy
Allegheny Health Network

Pittsburgh, Pennsylvania, 15224, United States
Aomori Prefectural Central Hospital

Aomori, 030-8553, Japan
Asan Medical Center

Seoul, 5505, South Korea
Asst Spedali Civili Di Brescia

Brescia, 25123, Italy
Attikon University General Hospital

Athens, 12464, Greece
Azienda Ospedaliera Di Padova

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy
Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele - Ospedale Gaspare Rodolico

Catania, 95123, Italy
Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi

Bologna, 40138, Italy
Azienda Policlinico Universitario Umberto I

Roma, 00100, Italy
Beijing Peking Union Medical College Hospital

Beijing, 100730, China
CHU La Miletrie

Poitiers, 86021, France
CHU de Nice Archet I

Nice, 06202, France
Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau

Nîmes, 30029, France
Centro Ricerche Cliniche di Verona S.r.l.

Verona, 37134, Italy
Chonnam National University Hwasun Hospital

Hwasun-Gun, 58128, South Korea
Chu De Grenoble

Grenoble, 38043, France
Churchhill Hospital

Oxford, OX3 7LI, United Kingdom
Cliniques Universitaires UCL de Mont-Godine

Yvoir, 5530, Belgium
Complejo Hospitalario Universitario De Santiago

Santiago de Compostela, 15706, Spain
Cork University Hospital

Cork, T12 DFK4, Ireland
Evangelismos General Hospital of Athens

Athens, 10676, Greece
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Georgios Papanikolaou General Hospital of Thessaloniki

Thessaloniki, 57010, Greece
Gosford Hospital

Gosford, 2250, Australia
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli

Reggio Calabria, 89124, Italy
Groupe Hospitalier Sud Hopital Haut Leveque USN

Pessac, 33604, France
Guangdong General Hospital

Guangzhou, 510030, China
Hadassah Medical Organization

Jerusalem, 91120, Israel
Heart of England NHS Foundation Trust

Birmingham, B9 5SS, United Kingdom
Hopital Saint Louis

Paris, 75475, France
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital Clinico Universitario De Valencia

Valencia, 46010, Spain
Hospital Italiano de Buenos Aires

Buenos Aires, C1199ABB, Argentina
Hospital Italiano de La Plata

La Plata, Buenos Aires, B1900AX, Argentina
Hospital Universitari Germans Trias i Pujol ICO Badalona

Barcelona, 08916, Spain
Hospital Universitario 12 De Octubre

Madrid, 28041, Spain
Hospital Universitario De Gran Canaria Dr. Negrin

Las Palmas de Gran Canaria, 35012, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
IC La Serena Research

La Serena, Coquimbo Region, 1720430, Chile
ICANS Institut de cancerologie Strasbourg Europe

Strasbourg, 67200, France
IRCCS - Istituto Romagnolo per lo Studio Dei Tumori "Dino Amadori" (IRST)

Meldola (fc), Fc, 47014, Italy
Johannes Wiesling Klinikum Minden

Minden, 32429, Germany
John Theurer Cancer Center

Hackensack, New Jersey, 07601-2191, United States
Kameda General Hospital

Kamogawa, 296-8602, Japan
Kindai University Hospital- Osakasayama Campus

Sayama, Osaka, 5898511, Japan
Krankenhaus der Elisabethinen Linz, I Interne Abteilung

Linz, 4020, Austria
Kyungpook National University Hospital

Daegu, 700-721, South Korea
Local Institution - 108

St Louis, Missouri, 63110, United States
Local Institution - 110

Los Angeles, California, 90095, United States
Local Institution - 112

Chicago, Illinois, 60612, United States
Local Institution - 114

Ann Arbor, Michigan, 48109, United States
Local Institution - 119

Salt Lake City, Utah, 84112, United States
Local Institution - 124

Lexington, Kentucky, 40536-0293, United States
Local Institution - 130

Knoxville, Tennessee, 37920, United States
Local Institution - 133

Plantation, Florida, 33322, United States
Local Institution - 135

Orlando, Florida, 32804, United States
Local Institution - 161

Medellín, Antioquia, 50034, Colombia
Local Institution - 162

Floridablanca, Soto, 681002, Colombia
Local Institution - 163

Bogotá, Distrito Capital de Bogotai, 111511, Colombia
Local Institution - 172

Ciudad Autónoma de BuenosAires, Buenos Aires, C1280AEB, Argentina
Local Institution - 176

Sherbrooke, Quebec, J1H5N4, Canada
Local Institution - 177

Montreal, Quebec, H1T 2M4, Canada
Local Institution - 179

Edmonton, Alberta, T6G 2S2, Canada
Local Institution - 180

Toronto, Ontario, M5G 2M9, Canada
Local Institution - 181

Calgary, Alberta, T2N 4N2, Canada
Local Institution - 183

Vancouver, British Columbia, V6Z 2A5, Canada
Local Institution - 192

Las Condes, Metropolitana de Santiago, 7560742, Chile
Local Institution - 193

Santiago, 7500587, Chile
Local Institution - 202

Palma de Mallorca, 7120, Spain
Local Institution - 208

Granada, 18014, Spain
Local Institution - 245

Terni, 05100, Italy
Local Institution - 246

Napoli Campania, 80131, Italy
Local Institution - 248

Pisa, 56100, Italy
Local Institution - 249

Roma, 144, Italy
Local Institution - 250

Ancona, 60126, Italy
Local Institution - 251

Roma, 00189, Italy
Local Institution - 259

Torino, 10126, Italy
Local Institution - 271

Vienna, 1090, Austria
Local Institution - 272

Graz, 8036, Austria
Local Institution - 274

Vienna, 1140, Austria
Local Institution - 297

Leipzig, 04103, Germany
Local Institution - 299

Düsseldorf, 40225, Germany
Local Institution - 300

Hamburg, 22081, Germany
Local Institution - 301

Mannheim, 68167, Germany
Local Institution - 312

Brussels, 1200, Belgium
Local Institution - 313

Hasselt, 3500, Belgium
Local Institution - 315

Verviers, 4800, Belgium
Local Institution - 316

Roeselare, 8800, Belgium
Local Institution - 318

Bruges, 8000, Belgium
Local Institution - 319

Liège, 4000, Belgium
Local Institution - 324

Créteil, 94010, France
Local Institution - 327

Lille, 59037, France
Local Institution - 330

Toulouse, 31059, France
Local Institution - 331

Angers, 49033, France
Local Institution - 332

Lyon, 69008, France
Local Institution - 333

Clermont-Ferrand, 63000, France
Local Institution - 341

Prague, 128 08, Czechia
Local Institution - 383

Alexandroupoli, 08100, Greece
Local Institution - 386

Athens, 11 527, Greece
Local Institution - 387

Pátrai, Achaia, 264 43, Greece
Local Institution - 391

Bucharest, 022328, Romania
Local Institution - 395

Craiova, Dolj, 200143, Romania
Local Institution - 433

Poznan, 61-696, Poland
Local Institution - 435

Wroclaw, 50367, Poland
Local Institution - 436

Gdansk, 80-952, Poland
Local Institution - 462

Budapest, 1096, Hungary
Local Institution - 463

Győr, 9023, Hungary
Local Institution - 500

Moscow, 125284, Russia
Local Institution - 502

Saint Petersburg, 197341, Russia
Local Institution - 503

Saint Petersburg, 197022, Russia
Local Institution - 550

Badaro Beirut, 11072280, Lebanon
Local Institution - 551

Saida, South, 652, Lebanon
Local Institution - 552

Beirut, 11-3288, Lebanon
Local Institution - 643

Seongnam-si, 13620, South Korea
Local Institution - 647

Seoul, 06351, South Korea
Local Institution - 661

Hong Kong, 0, Hong Kong
Local Institution - 701

Bunkyo-ku, Tokyo, 113-8431, Japan
Local Institution - 706

Maebashi, 371-8511, Japan
Local Institution - 708

Sapporo, 003-0006, Japan
Local Institution - 709

Chūō, Yamanashi, 409-3898, Japan
Local Institution - 710

Shinjyuku-ku, 160-0023, Japan
Local Institution - 713

Bunkyō City, 113-8677, Japan
Local Institution - 717

Kamakura, 247-8533, Japan
Local Institution - 800

Tianjin, 300041, China
Local Institution - 801

Shanghai, 200233, China
Local Institution - 802

Changchun, 130021, China
Local Institution - 804

Nanjing, Jiangsu, 210029, China
Local Institution - 809

Shanghai, 200025, China
Local Institution - 810

Zhengzhou, 0, China
Local Institution - 811

Suzhou, 215006, China
Local Institution - 816

Taiyuan, Shanxi, 030001, China
Local Institution - 818

Nantong, Jiangsu, 226001, China
Local Institution - 820

Nanchang, Jiangxi, 330006, China
Local Institution - 821

Qingdao, Shandong, 0, China
Mater Misercordiae Hospital

Dublin, 7, Ireland
Meir Medical Center

Kfar Saba, 44281, Israel
Monash Medical Centre

Clayton, Victoria, 3168, Australia
Mount Sinai Medical Center

New York, New York, 10029, United States
NTT Medical Center Tokyo

Shinagawa-ku, Tokyo, 141-8625, Japan
Nanchang University - The Second Affiliated Hospital

Nanchang, Jiangxi, 330008, China
Nanfang Hospital of Southern Medical University

Guangzhou, GD, 510515, China
Nottingham City Hospital

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
Ogaki Municipal Hospital

Ōgaki, 503-8502, Japan
Onco Card SRL

Brasov, 500052, Romania
Osaka Metropolitan university Hospital

Osaka, 545-8586, Japan
Prince of Wales Hospital the Chinese University of Hong Kong

Shatin, 0, Hong Kong
Prof. Dr. I. Chiricuta Institute of Oncology

Cluj-Napoca, 400015, Romania
Rambam Medical Center

Haifa, 31096, Israel
Royal Hobart Hospital

Hobart, 7000, Australia
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie

Krakow, 31-501, Poland
Seoul National University Hospital

Seoul, 3080, South Korea
Shamir Medical Center - Assaf Harofeh

Ẕerifin, 70300, Israel
Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
Sir Mortimer B. Davis - Jewish Genl

Montreal, Quebec, H3T 1E2, Canada
Specjalistyczny Szpital im. dra Alfreda Sokolowskiego

Wałbrzych, 58-309, Poland
St James Hospital

Dublin, Dublin 8, Ireland
Stauferklinikum Schwab. Gmund

Baden-Warttemberg, 73557, Germany
Tel-Aviv Sourasky Medical Center

Tel Aviv, Tel Aviv, 64239, Israel
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Catholic University of Korea Seoul - Saint Mary's Hospital

Seoul, 06591, South Korea
The First Affiliated Hospital Of Harbin Medical University

Harbin, 150081, China
The First Affiliated Hospital of Nanyang Medical College

Nanyang, Henan, China
The Japanese Red Cross Nagasaki Genbaku Hospital

Nagasaki, Nagasaki, 8528511, Japan
The Second Affiliated Hospital Of Kunming Medical University

Kunming, Yunnan, 650101, China
The University of Texas - MD Anderson Cancer Center

Houston, Texas, 77030, United States
Tianjin Medical University General Hospital

Tianjin, 300052, China
Tokai University Hospital

Isehara City, Kanagawa, 259-1193, Japan
Tokyo Women's Medical University Hospital

Shinjuku, 162-8666, Japan
Toyohashi Municipal Hospital

Toyohashi, 441-8570, Japan
United Lincolnshire Hospitals NHS Trust

Boston, PE21 9QS, United Kingdom
Universita degli Studi dell'Insubria - Ospedale di Circolo e Fondazione Macchi - Varese

Varese, 21100, Italy
Universitaetsklinikum Jena

Jena, 07740, Germany
Universitario de Salamanca - Hospital Clinico

Salamanca, 37007, Spain
Universitatsklinikum Halle Saale

Halle, 06120, Germany
University General Hospital of Patras

Rio Patras, 26500, Greece
University Hospital - London Health Sciences Centre

London, Ontario, N6C 6B5, Canada
University of Miyazaki Hospital

Miyazaki, 889-1692, Japan
University of Pittsburg Medical Center

Pittsburgh, Pennsylvania, 15213, United States
Unviversitatsklinikum Aachen

Aachen, 52074, Germany
Uz Leuven

Leuven, 3000, Belgium
Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Lodzi

Lodz, 93-510, Poland
Xiangya Hospital Central-South University

Changsha, Hunan, 410008, China

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